№ files_lp_4_process_3_101520
File format: docx
Character count: 10938
File size: 865 KB
Year:
2026
Region / city:
Torino, Italy; Parma, Italy
Subject:
Pharmaceutical formulation stability; pulmonary drug delivery
Document type:
Research article
Institution:
Politecnico di Torino; Chiesi Farmaceutici S.p.A.
Authors:
Lorena Pasero, Adamo Sulpizi, Tomaso Guidi, Roberto Pisano
Target audience:
Pharmaceutical scientists, formulation researchers
Study period:
2026
Methods:
Spray freeze-drying, scanning electron microscopy, X-ray diffraction
Active substances:
Salbutamol sulphate, mannitol
Excipients:
L-leucine, dextran, polysorbate 80
Storage conditions tested:
Room temperature, 5°C, -20°C
Intermediate freezing step:
1 h, 5 h
Key findings:
Dextran stabilizes δ-mannitol, prevents recrystallization and morphological changes
Context:
Experimental study on the stability and morphological changes of spray freeze-dried mannitol microparticles for inhalation delivery under different storage and formulation conditions
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Year:
2013–2016
Region / City:
Belo Horizonte, Brazil
Topic:
Systemic Lupus Erythematosus, Endothelial Microparticles
Document Type:
Research Article
Institution:
Federal University of Minas Gerais, Santa Casa Hospital
Authors:
Walter B. Cicarini, Karine S. Ferreira, Cristina M.G. Loures, Renato V. Consoli, Cláudia L.S. Neiva, Paulo M. Pádua, Fernanda F.C. Nunes, Luan C.V. Alves, Edna A. Reis, Vicente P.C.P Toledo, Bashir A. Lwaleed, Maria G. Carvalho
Funding:
CNPq, CAPES, FAPEMIG
Study Design:
Cross-sectional
Participants:
90 women, including healthy volunteers and SLE patients with low and moderate/high disease activity
Methods:
Blood collection, ultracentrifugation, flow cytometry
Outcome Measures:
Endothelial microparticles levels, correlation with SLEDAI-2K Score and age
Ethical Approval:
Research Ethics Committee of the Federal University of Minas Gerais, Reference 01928412.8.0000.5149
Inclusion Criteria:
Women aged-matched, SLE diagnosis per ACR criteria 1997
Exclusion Criteria:
Other autoimmune diseases, anticoagulant use, pregnancy, immunosuppressive diseases
Treatment:
Azathioprine, Prednisone, Hydroxychloroquine
Corresponding Author:
Bashir A. Lwaleed, University of Southampton, UK
Year:
2025
Region / city:
United Kingdom
Topic:
Immunization, Influenza Vaccine
Document Type:
Addendum
Organization / Institution:
UK Health Security Agency (UKHSA)
Author:
Suki Hunjunt, Alex Allen, Greta Hayward
Target Audience:
Health professionals, Immunization Programs
Effective Period:
1 September 2025 - 1 April 2026
Approval Date:
6 August 2025
Modification Date:
23 July 2025
Background:
Live attenuated influenza vaccine nasal spray suspension (Fluenz®) updated formula
Contextual Description:
Addendum to UKHSA PGD v15.0 detailing updates to the influenza vaccine composition and active strains.
Year:
2025
Region / city:
England
Topic:
Influenza Vaccination
Document Type:
Patient Group Direction (PGD)
Authority / institution:
UK Health Security Agency (UKHSA)
Author:
Suki Hunjunt, Jamie Lopez-Bernal, Greta Hayward
Target Audience:
Healthcare practitioners, immunisation staff
Period of validity:
From 1 September 2025 to 1 April 2026
Approval Date:
1 July 2025
Amendment Date:
25 June 2025
Year:
2024
Region / City:
EMEA
Therapeutic Area:
Allergic rhinitis
Document Type:
Product Information
Organization / Institution:
European Medicines Agency
Author:
Not specified
Target Audience:
Healthcare professionals
Validity Period:
Not specified
Approval Date:
Not specified
Amendment Date:
Not specified
Year:
2024-2025
Region / City:
Washington State
Topic:
Medical authorization form
Document Type:
Medical Authorization
Organization:
Washington State School for the Blind
Author:
Licensed Health Professional
Target Audience:
Parents/Guardians, School Staff
Effective Period:
07/01/2024 - 08/31/2025
Approval Date:
Not specified
Modification Date:
Not specified
Date:
26 September 2024
Tender Reference Number:
HFHK/0083/2024
Organization:
Habitat for Humanity Kenya
Type of Document:
Tender Advertisement and Request for Quotation
Item Description:
Supply of Seeds and Fertilizers/Chemical Spray (YARA Brand)
Delivery Location:
Kandutura Area in Rumuruti and Naibor Area in Nanyuki, Laikipia County, Kenya
Submission Deadline:
4 September 2024 (Close of Business)
Submission Address:
The Chairperson, Procurement Committee, Habitat for Humanity Kenya, Kasuku Lane-off Lenana Road, P.O Box 38948 – 00623, Nairobi, Kenya
Eligibility Requirements:
Valid KRA PIN/VAT/Tax Compliance Certificate; CR12; Valid Business Permit; 3 Similar Works (LPOs/Contracts); 2–3 Years of Operation; Company Profile
Tax Requirement:
VAT 16% where applicable
Currency:
Kenyan Shillings (KES)
Contact Source:
https://hfhkenya.org/tenders
Target Suppliers:
Eligible and Competent Suppliers of Agricultural Inputs
Procurement Conditions:
Right to Accept or Reject Any Tender; No Canvassing; Communication Only to Successful Bidders
Issuing Authority:
Mississippi Department of Environmental Quality (MDEQ)
Program:
National Pollutant Discharge Elimination System (NPDES)
Permit Type:
Wet Deck Log Spray with Recirculation General Permit
Permit Number:
MSG17 (number assigned by state)
Document Type:
Forms Package and Notice of Intent (NOI)
Applicable To:
Industrial Facilities
Submission Requirement:
File at least 30 days prior to commencement of regulated industrial activity
Required Attachments:
USGS quadrangle map; site drawings; engineer-certified plans for new or expanding facilities
Regulatory References:
State of Mississippi Wastewater Regulations
Related Forms Included:
Notice of Intent; Request for Termination of Coverage; Request for Transfer of Permit; Property Line Buffer Zone Waiver Form; Contiguous Land Owner Notification Form; Example Public Notice; Library Form; Acknowledgement Library Form
Geographic Information Required:
Latitude and Longitude of facility and outfalls
Additional Requirements:
Proof of registration with Mississippi Secretary of State for business entities; documentation of compliance with other environmental permits
Year:
2025
Region / City:
England
Topic:
Youth justice, child welfare, criminal justice
Document type:
Statement
Organization:
British Association of Social Workers (BASW)
Author:
Wayne Reid
Target audience:
Ministry of Justice, youth custody staff, social workers, child welfare advocates
Date of approval:
24 April 2025
Date of revisions:
Not specified
Authors:
Ruixin Zhou; Carolyn Jordan; Justin Lygrisse; Adrian Raiche
Organization:
Kindeva Drug Delivery, Lexington, KY, USA
Address:
1513 Bull Lea Road, Lexington, KY 40511, USA
Regulatory Authority Referenced:
U.S. Food and Drug Administration (FDA)
Regulatory Document Referenced:
FDA Guidance for Industry: Nasal Spray and Inhalation Solution, Suspension, and Spray Drug Products – Chemistry, Manufacturing, and Controls Documentation (July 2002)
Drug Product:
RezenopyTM
Dosage Form:
Nasal spray drug product
Study Type:
Comparative spray characterization and statistical equivalence study
Testing Parameters:
Spray pattern; Droplet size distribution (DV10, DV50, DV90, Span, %Volume < 10 µm); Delivered dose (% of label claim)
Media Compared:
USP Purified Water (USP-PW); Placebo formulation; Drug product formulation
Sample Size:
n=90 per test (30 samples per group)
Statistical Method:
Two-sample equivalence test; 95% confidence interval
Software Used:
Viota® Software; Minitab Statistical Software (version 22.1)
Equipment:
SprayVIEW® measurement system; Spraytec® system
Components Evaluated:
Incoming actuator (pump) lots; Finished combination product
Regulatory Context:
NDA filing; FDA-approved nasal spray product
Year:
2009
Region / City:
East Africa
Topic:
Tick-borne diseases, livestock health
Document type:
Script
Author:
Unknown
Target audience:
Broadcasters, farmers, livestock keepers
Period of action:
Ongoing
Approval date:
4 July 2009
Date of changes:
Not specified
Year:
2026
Region / City:
Nottingham, UK
Topic:
Nasal drug delivery, spray drying technology
Document type:
Research paper
Institution:
Upperton Pharma Solutions
Authors:
Lara C. Penn, Shailesh K. Mistry, Richard Johnson
Target Audience:
Pharmaceutical scientists, researchers in drug delivery systems
Date of approval:
2026
Date of amendments:
None
Year:
2022
Region / City:
Al-Hussainiya, Karbala Governorate, Iraq
Subject:
Avocado sapling growth and chemical composition
Document Type:
Research Article
Institution:
Local agricultural nursery
Author:
Not specified
Target Audience:
Agronomists, horticulturists, researchers in tropical fruit cultivation
Experimental Design:
Randomized Completely Block Design (RCBD) factorial
Treatment Factors:
Humic acid concentrations (0, 3, 5 ml/L), Seaweed extract concentrations (0, 2, 4, 6 ml/L)
Measurement Period:
March–November 2022
Measured Parameters:
Plant height, stem diameter, number of branches, number of leaves, leaf area, leaf carbohydrates, macronutrients (N, P, K, Ca)
Application Method:
Foliar spray
Key Findings:
Combined application of 5 ml/L humic acid and 6 ml/L seaweed extract maximized vegetative growth and leaf nutrient content
Year:
2018
Region / City:
Global
Topic:
Gasoline spray and mixing in direct-injection engines
Document Type:
Guidelines
Organization:
ECN
Authors:
David Schmidt, Tommaso Lucchini, Joaquin de la Morena
Target Audience:
Researchers, engineers, and institutions involved in spray and combustion studies
Period of Application:
From 2018 onwards
Approval Date:
Not specified
Date of Revisions:
Not specified
Note:
Year
Subject:
Work Health and Safety
Document Type:
WHS Management Plan
Organization:
RPQ Spray Seal Pty Ltd
Target Audience:
Workers, Contractors
Year:
2009
Recipient:
Laboratory Group E
Sender:
Tony Butterfield, Engineering Training Supervisor
Subject:
Instant Tea Production
Client:
Small tea leaf producer
Type of document:
Memorandum
Location:
Not specified
Target audience:
Laboratory team
Date issued:
August 26, 2009
Deadline for meeting:
September 9, 2009
Technical focus:
Spray drying, particle size distribution, yield estimation, thermal stability of tea