№ files_lp_4_process_2_57745
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Supplementary methodological description of laboratory staining procedures, imaging protocols, sequencing workflows, and computational analyses used to characterize immune cell infiltration and genomic variation in tumor biopsy samples.
Document type:
Supplementary methods section
Scientific field:
Molecular medicine and tumor immunology
Techniques described:
Immunofluorescence histology, multiplex antibody staining, next-generation sequencing
Biological material:
Tumor biopsy FFPE tissue sections
Immune markers analyzed:
CD8+, CD4+, Granzyme B
Sequencing platforms:
Illumina NovaSeq 6000
Bioinformatics tools:
trim_galore, STAR, featureCounts, DESeq2, GATK HaplotypeCaller, MuTect, Vardict
Genome reference:
Human genome hg38 with appended ONCOS-102 genome
Imaging equipment:
Panoramic 250 FLASH whole-slide scanner
Institutions mentioned:
Institute for Molecular Medicine Helsinki; Personalis Inc., California, USA
Sample preparation:
3.5 μm FFPE tissue sections
Staining reagents:
TSA 647, TSA 750, DAPI nuclear stain
Analysis focus:
Detection and quantification of immune cell infiltrates and differential gene expression in tumor biopsies
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Year:
Not specified
Region / City:
Not specified
Topic:
Cancer research, Urothelial carcinoma
Document type:
Research methodology
Institution:
Not specified
Author:
Not specified
Target audience:
Researchers in oncology and immunology
Period of validity:
Not specified
Approval date:
Not specified
Modification date:
Not specified
Year:
2023
Region / city:
Parkville, Victoria, Australia
Topic:
Immunofluorescence, laboratory techniques
Document type:
Laboratory protocol
Organization:
Walter and Eliza Hall Institute of Medical Research
Author:
Thanh Ngoc Nguyen
Target audience:
Laboratory researchers, biotechnologists
Date of approval:
Not specified
Date of changes:
Not specified
Year:
2001
Region / City:
UK
Subject:
Dermatology, Nursing, Skin Cancer
Document Type:
Protocol
Organization / Institution:
Not specified
Author:
Not specified
Target Audience:
Registered Nurses, Dermatology Practitioners
Period of Effect:
Ongoing
Approval Date:
Not specified
Date of Amendments:
Not specified
Number of patients:
80
Setting:
Intensive care unit
Procedure:
Transvenous renal biopsy
Study design:
Observational analytical study
Statistical methods:
Student’s t-test; Wilcoxon’s rank test; χ2 test; logistic regression with backward-stepwise variable elimination
Outcomes assessed:
Composite complication endpoint; acute tubular necrosis diagnosis; diagnostic yield; in-ICU mortality; therapeutic consequences
Variables analyzed:
Demographic characteristics; clinical scores (SOFA, SAPS II); laboratory parameters; anticoagulation and antiplatelet therapy; bleeding-risk factors; vasopressor use; mechanical ventilation; extracorporeal membrane oxygenation
Time comparison:
TVRB performed before 2012 vs after 2012; biopsy after 2015
Therapeutic interventions evaluated:
Corticosteroids; cyclophosphamide; plasmapheresis; intravenous immunoglobulins; rituximab; eculizumab; calcineurin inhibitors; anticoagulation
Definition of composite endpoint:
Renal hematoma; macroscopic hematuria; transfusion during days 1–3 post-TVRB; SOFA score increase ≥1 point from TVRB day to day +3; hemoglobin decrease ≤ –2 g/dL from TVRB day to day +3
Year:
2019
Region / city:
Cambridge, United Kingdom
Topic:
Hereditary diffuse gastric cancer, endoscopic surveillance, biopsy techniques
Document type:
Clinical Trial Study
Organization / institution:
University of Cambridge
Target audience:
Medical professionals, researchers, and clinicians involved in hereditary cancer surveillance
Period of action:
October 2017 - December 2018
Approval date:
Not specified
Date of changes:
Not specified
Year:
2025
Region / city:
Rivers State, Nigeria
Subject:
Lymphadenopathy, Histopathological analysis
Document Type:
Research Study
Institution:
Rivers State University Teaching Hospital
Author:
Not specified
Target Audience:
Medical professionals, Researchers
Study Period:
1st January 2019 – 31st December 2025
Approval Date:
Not specified
Date of Changes:
Not specified
Year:
2025
Region / city:
Rivers State, Nigeria
Subject:
Lymphadenopathy, Histopathological analysis
Document Type:
Research Article
Organization / Institution:
Rivers State University Teaching Hospital
Author:
Not specified
Target Audience:
Healthcare professionals, researchers in the medical field
Effective Date:
January 1, 2019
Date of Last Update:
December 31, 2025
Year:
2021
Region / city:
Manchester, United Kingdom
Topic:
Liquid biopsy in biliary tract cancer
Document type:
Review article
Organization / institution:
The Christie NHS Foundation Trust, University of Manchester
Authors:
Shotton R, Lamarca A, Valle J, McNamara MG
Target audience:
Researchers, medical professionals
Period of action:
Not specified
Date of approval:
August 11, 2021
Date of revisions:
June 14, 2021
Date of publication:
2021
Keywords:
Biliary tract cancer, Liquid biopsy, Circulating tumour DNA, Cell free DNA, Circulating tumour cells, Biomarkers
Clinical trials:
Currently recruiting trials involving liquid biopsy in biliary tract cancer
Abstract:
This article reviews the potential role of liquid biopsies in diagnosing, predicting, and monitoring biliary tract cancers, including circulating tumour DNA, microRNA, and tumour cells, along with current clinical trials.
Year:
2025
Region / city:
Irvine, California
Topic:
Automotive, Design, SUV
Document type:
Press release
Organization:
Kia America
Author:
Kia Design Center America
Target audience:
Automotive enthusiasts, journalists, consumers
Period of validity:
2025–2026
Approval date:
November 10, 2025
Modification date:
N/A
Year:
2023
Region / City:
Hefei, PR China
Theme:
Superconducting Tokamak, Plasma Physics
Document Type:
Research Paper
Institution:
Institute of Energy, Hefei Comprehensive National Science Center, Institute of Plasma Physics, Chinese Academy of Sciences
Author:
Yi Yu, Houxiang Han
Target Audience:
Researchers, Plasma Physicists, Engineers in Fusion Energy
Period of Validity:
Not applicable
Approval Date:
Not specified
Modification Date:
Not specified
Date:
June 24, 2020
Status:
Confidential / not validated
Product name:
BactiBag
Technology:
Bacteriostatic packaging with BactiGuard coating
Active agent:
Triclosan (hexachlorophene) at ultra-low release concentration
Intended use:
Swine artificial insemination semen packaging
Developer:
IMV Technologies
Document type:
Master document with key messages and questions and answers
Industry:
Animal reproduction and biotechnology
Geographical scope:
International
Launch year referenced:
2015
Target audience:
Swine breeders and artificial insemination centers
Studies referenced:
In vitro studies and field studies on sows in France, Germany, and Russia
Scale of field data:
Nearly 4,000 sows
Quality control measures:
Infrared spectrophotometry, laboratory testing, pressurized sealing tests
Units sold:
Over 10 million units
Countries referenced:
France, Germany, Russia
Source type:
Corporate technical and marketing communication
Date:
April 29, 2021
Region / City:
Munich (Germany) / Paris (France) / Madrid (Spain)
Topic:
Aviation, Military Defense, Aerospace
Document Type:
Press Release
Organization / Institution:
MTU Aero Engines, Safran Aircraft Engines, ITP Aero
Author:
N/A
Target Audience:
General public, industry professionals, media
Effective Period:
Ongoing until 2040
Approval Date:
N/A
Amendment Date:
N/A
Context:
Press release announcing the cooperation between MTU Aero Engines, Safran Aircraft Engines, and ITP Aero for the development of the engine for Europe’s Next-Generation Fighter.
Year:
2008
Region / City:
Switzerland
Industry:
Financial services—Investment management and advice
Document Type:
Case Study
Organization:
Credit Suisse Asset Management
Author:
Microsoft
Target Audience:
Business and IT professionals in financial services
Period of Application:
Ongoing
Approval Date:
Not specified
Modification Date:
Not specified
Year:
2019
Region / City:
Washington, D.C.
Topic:
Telecommunications regulation, forbearance, broadband investment
Document Type:
Memorandum Opinion and Order
Agency:
Federal Communications Commission
Author:
Federal Communications Commission
Target Audience:
Telecommunications service providers, regulators, legal professionals
Period of Effectiveness:
N/A
Date of Approval:
July 26, 2019
Date of Amendments:
N/A
Document Number:
FCC 22-24
Release Date:
March 21, 2022
Docket Number:
AU Docket No. 20-429
Issuing Authority:
Federal Communications Commission
Bureaus:
Office of Economics and Analytics; Wireless Telecommunications Bureau
Subject:
Competitive bidding procedures for flexible-use licenses in the 2.5 GHz band
Auction Title:
Auction 108
Scheduled Bidding Start Date:
July 29, 2022
Spectrum Band:
2.5 GHz
Spectrum Amount:
117.5 megahertz
Number of Licenses:
Approximately 8,000 geographic overlay licenses
Auction Format:
Ascending clock auction (clock-1 format)
Related Proceeding:
2.5 GHz Report and Order
Applicable Law:
Communications Act of 1934, section 309(j)
Forms Referenced:
FCC Form 175; FCC Form 159; FCC Form 601; FCC Form 602
Public Notice Type:
Procedures, terms, conditions, dates, and deadlines for participation
Year:
2019
Region / City:
Novi, Michigan
Topic:
NATO Reference Mobility Model, vehicle mobility prediction, terrain analysis
Document Type:
Technical Paper
Organization / Institution:
NATO, U.S. Army, Michigan Technical University, Alion Science and Technology
Author:
Dr. David Gorsich, Dr. Richard Gerth, Scott Bradley, Michael Letherwood
Target Audience:
Military professionals, vehicle simulation experts, defense technology researchers
Period of Validity:
2014-2018
Approval Date:
August 13-15, 2019
Date of Changes:
N/A
Year:
2026
Region / City:
N/A
Topic:
Fluid Control, Microvalves, Robotics
Document Type:
Research Article, Supplementary Information
Institution:
Tsinghua University
Author:
Jie An, Yang Jiang, Xiaojian Xiang, Tao Jiang, Kai Wang, Zewei Ren, Zipei Tan, Jinhui Nie
Target Audience:
Researchers in robotics, fluid control, and microvalve technology
Period of Validity:
N/A
Date of Approval:
N/A
Date of Modifications:
N/A
Supplementary Materials:
Yes
Experimental Details:
Yes
Impact Studies:
Yes
Simulation Results:
Yes
Year:
2026
Region / City:
Global
Topic:
High-Speed Transportation, Quantum Levitation, Magnetic Recycling
Document Type:
Research Paper
Organization:
Not specified
Author:
Not specified
Target Audience:
Researchers, Engineers, Transportation Industry Professionals
Period of Validity:
Ongoing
Approval Date:
Not specified
Date of Changes:
Not specified
Contextual Description:
A research paper proposing a novel Hybrid Quantum-Assisted Levitation system integrated with Ambient Magnetic Recycling for sustainable high-speed transportation, focusing on reducing energy consumption and improving scalability.
Year:
2013
Region / City:
Worldwide
Topic:
Data Warehousing, Big Data, SQL Server
Document Type:
White Paper
Organization:
Microsoft
Authors:
Barbara Kess, Dan Kogan
Target Audience:
IT Professionals, Data Analysts, Business Intelligence Specialists
Period of Validity:
Not specified
Approval Date:
October 2013
Date of Changes:
Not specified
Year:
2026
Region / City:
United Kingdom
Subject:
Supercapacitors, renewable materials, carbon capture
Document Type:
Doctoral programme advertisement
Institution:
Net2Zero Centre for Doctoral Training, Aston University and partner universities
Supervisors:
Dr Stephen Worrall, Dr Matthew Derry, Dr Vesna Najdanovic
Programme Length:
Four years
Contract Type:
Full time
Prospective Start Date:
October 2026
Academic Year:
2026/27
Key Words:
Supercapacitors, bioderived carbon electrodes, ionogel electrolytes, sustainability, carbon capture
Target Audience:
Prospective doctoral students in engineering, materials science, and renewable energy
Application Deadline:
Until positions are filled
Financial Support:
Tax-free stipend £21,383 per year, tuition fees covered, research training grant
International Applicants:
Limited spaces, conditional on fee waiver