№ files_lp_4_process_3_103685
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Cross-sectional study evaluating the diagnostic accuracy of a 2-transcript RNA signature to distinguish bacterial from viral infection in febrile children using whole-blood gene expression profiling.
Year: 2016
Region / city: UK, Spain, Netherlands, USA
Topic: Pediatric infectious diseases, diagnostics
Document type: Research article
Institution: Imperial College London, Hospital Clínico Universitario de Santiago, University of California San Diego, Emma Children’s Hospital, University of Oxford, University of Southampton, University of Amsterdam, University of Queensland
Authors: Jethro A Herberg, Myrsini Kaforou, Victoria J Wright, Hannah Shailes, Hariklia Eleftherohorinou, Clive J Hoggart, Miriam Cebey-Lopez, Michael J Carter, Victoria A Janes, Stuart Gormley, Chisato Shimizu, Adriana H Tremoulet, Anouk M Barendregt, Antonio Salas, John Kanegaye, Andrew J Pollard, Saul N Faust, Sanjay Patel, Taco Kuijpers, Federico Martinon-Torres, Jane C Burns, Lachlan JM Coin, Michael Levin
Study period: 2009–2013
Population: Febrile children
Sample size: 370 children
Method: Whole-blood RNA expression profiling
Validation: Discovery and validation cohorts, additional datasets with meningococcal and inflammatory diseases
Key outcomes: Sensitivity and specificity of 2-transcript RNA signature (FAM89A and IFI44L) for bacterial vs viral infection
Corresponding author: Prof. Michael Levin, Imperial College London, [email protected]
Date of revision: 4 July 2016
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Management of the Febrile Child
Year: 2024
Region / city: Canberra
Topic: Paediatric care, fever management
Document type: Clinical Practice Guideline
Organization / institution: Canberra Health Services
Author: Paediatric Improvement Collaborative
Target audience: Clinicians, Paediatric healthcare providers
Period of validity: Until review date 29/09/2025
Date of approval: 29/09/2025
Date of amendments: 29/09/2025
Risk Stratification in Febrile Neutropenic Episodes in Adolescent / Young Adult Patients with Cancer
Year: 2023
Region / city: United Kingdom, Canada, Switzerland, The Netherlands, Germany
Subject: Risk Stratification in Medical Research
Document Type: Research Article
Organization / Institution: University of York, Leeds Teaching Hospitals, University of Leicester, The Hospital for Sick Children, University of Bern, University Medical Center Groningen, Johann Wolfgang Goethe University
Author(s): Robert S. Phillips, Kaljit Bhuller, Lillian Sung, Roland A. Ammann, Wim J. E. Tissing, Thomas Lehrnbecher, Lesley A Stewart
Target Audience: Medical Researchers, Oncologists, Pediatricians, Healthcare Professionals
Period of Validity: Not specified
Approval Date: Not specified
Date of Changes: Not specified
Antibiotics and cure rates in childhood febrile urinary tract infections: a systematic review and meta-analysis (1990–2016)
Year: 1990–2016
Region / City: International, multicenter
Topic: Pediatric febrile urinary tract infections, antibiotic efficacy
Document Type: Systematic review and meta-analysis
Institution / Organization: St George’s University of London; University of Athens; Institut National de la Santé et de la Recherche Médicale, Université Paris Diderot; University Children’s Hospital Basel; University of Pennsylvania School of Medicine
Authors: Konstantinos Vazouras, Romain Basmaci, Julia Bielicki, Laura Folgori, Theoklis Zaoutis, Mike Sharland, Yingfen Hsia
Study Population: Children aged 0–18 years with febrile urinary tract infections without major underlying conditions
Number of Studies Reviewed: 30 clinical trials
Total Cases Analyzed: 3,913
Antibiotics Evaluated: Cephalosporins, aminoglycosides, other antimicrobials
Key Outcomes: Clinical cure rates, microbiological cure rates, treatment failure rates
Data Sources: Medline, Embase, Cochrane Central
Inclusion Criteria: Randomized clinical trials reporting on clinical and/or microbiological efficacy of antibiotics in pediatric febrile UTIs
Exclusion Criteria: Lower urinary tract infections, patients with underlying conditions, long-term endpoints >1 month
Topics: 2-transcript discriminating Febrile