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Preclinical data detailing the structure and mechanism of BiTE® molecules, cytotoxic activity of AMG 596 against EGFRvIII-positive tumor cells, and T-cell responses in vitro and in orthotopic mouse models.
Year: 2026
Study Type: Preclinical research
Organ / Institution: Not specified
Authors: Not specified
Species: Cynomolgus monkey, human cell lines
Target: EGFRvIII-positive tumor cells
Experimental Methods: Flow cytometry, immunohistochemistry, transwell assays, cytokine analysis
Cell Lines: U-87 MG/EGFRvIII, U-251 MG
Drug Tested: AMG 596
Assay Duration: 48–72 hours
T-cell Subtypes Analyzed: CD3+, CD4+, CD8+
Accession Numbers: XP_005549616.1, NP_005219.2
Publication Type: Supplementary figures for a scientific study
Price: 8 / 10 USD
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Supplementary Figure S4: Total ADC, Total mAb and Free MMAE Levels Following a Single Dose of MYTX-011 in Cynomolgus Monkeys
Document Type: Supplementary scientific figure description
Study Subject: Cynomolgus monkeys
Sample Size: n=3 per group
Test Article: MYTX-011
Dose: 6.0 mg/kg single dose
Analytes Measured: Total ADC, total mAb, free MMAE
Biological Matrix: Blood
Analytical Method: LC-MS/MS assays
Research Context: Pharmacokinetic measurement following administration of an antibody–drug conjugate
Key Observation: Similar levels of total mAb and total ADC indicating high stability of site-specific conjugation
Supplementary information Comprehensive characterization of the chemical constituents in Yiganmingmu oral liquid and the absorbed prototypes in cynomolgus monkey plasma after oral administration by UPLC-Q-TOF-MS based on the self built components database
Year: 2023
Region / City: Guangzhou, Nanning, Qinzhou
Theme: Chemical Constituents, Pharmacology
Document Type: Research Paper
Organization / Institution: Jinan University, Guangxi University of Chinese Medicine, Guangxi Hebabiz Pharmaceutical Co. Ltd.
Author: Wei Wei, Siwei Li, Linyou Cheng, Erwei Hao, Xiaotao Hou, Hua Zhou, Jiagang Deng, Xinsheng Yao
Target Audience: Researchers, Pharmacologists, Chemists
Period of Action: N/A
Approval Date: N/A
Date of Modifications: N/A
Topics: EGFRvIII 596 Cynomolgus