№ files_lp_3_process_9_24885
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Scientific abstract reporting a proteomic analysis of human knee articular cartilage demonstrating zone-specific and age- and osteoarthritis-related differences in protein abundance and associated inflammatory and cell death pathways.
Document type: Conference abstract submission form
Presentation type: Poster
Submission category: Poster Prize
Author: Aibek Smagul
Co-authors: Deborah Simpson; Simon Tew; Mandy J. Peffers
Affiliations: Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK; Centre for Proteome Research, Institute of Integrative Biology, University of Liverpool, Liverpool, UK
Corresponding email: [email protected]
Institution: University of Liverpool
Research field: Proteomics; Osteoarthritis; Musculoskeletal disease
Study population: Human cartilage donors (young n=5, mean age 32; old n=5, mean age 71; OA n=5, mean age 76)
Methods: Laser microdissection; in-situ trypsin digestion; liquid chromatography-tandem mass spectrometry; label-free quantification; pathway analysis
Sample site: Knee articular cartilage (superficial, middle and deep zones)
Word limit: 350 words
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Publications: (*Corresponding Author)Rios-Arce ND, Murugesh DK, Hum NR, Sebastian A, Jbeily EH, Christiansen BA, Loots GG. Preexisting type 1 diabetes mellitus blunts the development of posttraumatic osteoarthritis. JBMR Plus. 2022;6:(5):e10625.*Christiansen BA, Chan DD, van der Meulen MCH, Maerz T. Small-animal compression models of osteoarthritis. Methods in Molecular Biology: Cartilage Tissue Engineering. 2022; In Press.Hsia AW, Jbeily EH, Mendez ME, Cunningham HC, Biris KK, Bang H, Lee CA, Loots GG, *Christiansen BA. Post-traumatic osteoarthritis progression is diminished by early mechanical unloading and anti-inflammatory treatment in mice. Osteoarthritis Cartilage. 2021;29:(12):1709-1719.
Year: 2022
Region / City: Not specified
Topic: Post-traumatic osteoarthritis, diabetes, osteoarthritis models
Document Type: Journal Articles
Organization / Institution: Various medical research institutions
Authors: Rios-Arce ND, Murugesh DK, Hum NR, Sebastian A, Jbeily EH, Christiansen BA, Loots GG, Christiansen BA, Chan DD, van der Meulen MCH, Maerz T, Hsia AW, Jbeily EH, Mendez ME, Cunningham HC, Biris KK, Bang H, Lee CA, Loots GG
Target Audience: Medical professionals, researchers in osteoarthritis and diabetes
Period of validity: 2021-2022
Approval Date: Not specified
Date of revisions: Not specified
Temporal Control in Shell-core Structured Nanofilm for Tracheal Cartilage Regeneration: Synergistic Optimization of Anti-Inflammation and Chondrogenesis
Year: 2026
Region / City: Suzhou, Shanghai, Hangzhou, China
Field: Tissue Engineering, Regenerative Medicine
Document Type: Supplemental Information
Institution: Soochow University, Shanghai Jiao Tong University, Zhejiang Cancer Hospital
Authors: Wen Zhao, Fanglan Xu, Yumei Shen, Qifeng Ding, Yifei Wang, Leilei Liang, Wufei Dai, Yongbing Chen
Corresponding Authors: Leilei Liang, Wufei Dai, Yongbing Chen
Experimental Model: BMSCs-loaded nanofilms, rabbit tracheal defect model
Methods: Immunofluorescence staining, live/dead assay, CCK8 cell viability assay, tracheoscopy, MicroCT, HE staining
Treatment Groups: PLGA-GT, PLGA@ICA-GT, PLGA-GT@KGN, PLGA@ICA-GT@KGN
Observation Period: 2 weeks, 4 weeks, 8 weeks
Key Measurements: Cell viability, healing conditions (%), survival rate, histological evaluation
Topics: articular proteome cartilage