№ files_lp_4_process_2_43849
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Detailed tabular data summarizing clinical trials, dosing regimens, patient demographics, and observed resistance mutations in Gram-negative bacteria.
Year:
2009–2017
Region / City:
Shenzhen, Hangzhou, California, London, Overland Park, Michigan
Theme:
Antimicrobial resistance, Clinical pharmacology
Document type:
Supplementary data / Clinical study summary
Institution:
Shenzhen Institute of Respiratory Diseases; State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Zhejiang University; University of Southern California; AstraZeneca; Pfizer; Forest Laboratories
Authors:
Tingting Xu, Yuqi Guo, Yang Ji, Baohong Wang, Kai Zhou
Target audience:
Researchers in microbiology and pharmacology
Study population:
Adults and children (3 months–90 years), healthy volunteers and patients with infections
Clinical conditions:
Cystic fibrosis, complicated urinary tract infections, intra-abdominal infections, neutropenic febrile conditions, systemic infections, ICU patients
Trial phases:
I–IV
Interventions:
Ceftazidime–avibactam alone or in combination with other antibiotics
Completion dates:
2009–2017
Locations of resistance studies:
UK, in vitro assays
Organisms studied:
K. pneumoniae
Resistance mechanisms:
KPC-3 mutants with amino acid substitutions and insertions
Price: 8 / 10 USD
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Year:
2021
Region / City:
United Kingdom
Subject:
Health economics, antimicrobial evaluation
Document type:
Final report
Organization / Institution:
Centre for Health Economics, University of York; Health Economics and Decision Science, University of Sheffield
Author:
Sue Harnan, Ben Kearns, Alison Scope, Laetitia Schmitt, Dina Jankovic, Jean Hamilton, Ruth Wong, Tushar Srivastava, Harry Hill, Chu Chang Ku, Kate Ren, Claire Rothery, Laura Bojke, Mark Sculpher, Beth Woods
Target audience:
Healthcare professionals, policymakers, researchers
Period of validity:
2016 - ongoing
Approval date:
October 2021
Date of last modification:
October 2021
Year:
2020
Country:
Australia
Region:
Nationwide
Organisation:
Australian Group on Antimicrobial Resistance (AGAR)
Programme:
Australian Gram-negative Sepsis Outcome Programme (GnSOP)
Authors:
Jan M Bell; Alicia Fajardo Lubian; Sally R Partridge; Thomas Gottlieb; Jonathan Iredell; Denise A Daley; Geoffrey W Coombs
Type of document:
Annual surveillance report
Subject:
Antimicrobial resistance in gram-negative bloodstream infections
Pathogens studied:
Enterobacterales; Escherichia coli; Klebsiella pneumoniae; Enterobacter cloacae complex; Pseudomonas aeruginosa; Acinetobacter species
Sample size:
8,752 isolates
Study period:
1 January to 31 December 2020
Participating laboratories:
30 laboratories
Institutions covered:
49 institutions
Methodology:
Automated susceptibility testing; PCR screening; whole genome sequencing
Standards applied:
CLSI M100; EUCAST v11.0 (January 2021)
Key focus:
Resistance to third-generation cephalosporins; fluoroquinolones; piperacillin-tazobactam; carbapenems; colistin
Carbapenemase genes detected:
blaIMP-4; blaGES-5; blaNDM-1; blaNDM-5; blaOXA-48; blaOXA-181; blaIMI-1; blaOXA-23+NDM-1
Year:
2022
Region / City:
Australia
Topic:
Antimicrobial resistance, bloodstream infections, gram-negative pathogens
Document Type:
Annual Report
Institution:
Australian Group on Antimicrobial Resistance (AGAR)
Authors:
Jan M Bell, Alicia Fajardo Lubian, Sally R Partridge, Thomas Gottlieb, Jennifer Robson, Jonathan R Iredell, Denise A Daley, Geoffrey W Coombs
Target Audience:
Healthcare professionals, researchers, and policy makers in antimicrobial resistance
Date of Approval:
16/11/2023
Date of Last Update:
16/11/2023
Year:
Not specified
Region / City:
Not specified
Topic:
Bacterial biology, Gram-negative bacteria, Lipopolysaccharides
Document Type:
Educational Material
Organization / Institution:
Not specified
Author:
Not specified
Target Audience:
Students or professionals in microbiology
Period of Validity:
Not specified
Approval Date:
Not specified
Date of Changes:
Not specified
Year:
2024
Region / City:
Global
Topic:
Antimicrobial Activity, Silver Nanoparticles, Green Synthesis
Document Type:
Research Article
Organization / Institution:
Not specified
Author:
Not specified
Target Audience:
Researchers, Scientists in Biotechnology, Microbiology, and Nanotechnology
Period of Validity:
Not applicable
Approval Date:
Not specified
Modification Date:
Not specified
Year:
2026
Countries involved:
China, Greece, India, Malaysia, Mexico, Philippines, Romania, Russian Federation, Thailand, Spain
Study type:
Phase 3 randomized clinical trial
Therapeutic area:
Infectious diseases, antibacterial therapy
Pathogens:
Metallo-β-lactamase-producing Gram-negative bacteria
Interventions:
Aztreonam-avibactam, comparator therapy (best available therapy)
Patient population:
Adults ≥18 years with serious bacterial infections (cIAI, HAP, VAP, cUTI, BSI)
Enrollment period:
Screening to day 45 follow-up
Ethics approval:
Local IEC/IRB approvals in all participating countries
Primary endpoints:
Clinical and microbiological outcomes at test-of-cure (day 28 ±3)
Secondary endpoints:
Safety and tolerability during and after treatment
Authors:
George L. Daikos, José Miguel Cisneros, Yehuda Carmeli, Minggui Wang, Chee Loon Leong, Konstantinos Pontikis, Anastasia Anderzhanova, Simin Florescu, Roman Kozlov, Eduardo Rodriguez-Noriega, Mina Psichogiou, Pinyo Rattanaumpawan, Anca Streinu-Cercel, Venkatasubramanian Ramasubramanian, Francis F. Arhin, Halley Rogers, Michele Wible, Joanne Leaney, Daria Jacobson, Rienk Pypstra, Joseph W. Chow
Year:
2025
Country:
New Zealand
Type of document:
Guidelines
Issuing organization:
Health New Zealand | Te Whatu Ora
Based on previous version:
Ministry of Health, 2011, 2012
Publication date:
April 2025
Revisions date:
April 2025
ISBN:
978-1-991139-15-3
Scope:
Control and management of Legionella bacteria in water and soil systems
Target audience:
Public health officers, building owners, air conditioning engineers, employers, maintenance personnel
Source type:
Official public health guidance
Document type:
Laboratory exercise instructions
Subject area:
Microbiology
Educational level:
Undergraduate laboratory
Focus:
Bacterial growth media and culturing techniques
Topics covered:
Normal flora, aseptic technique, selective and differential media, colony morphology, hemolysis
Media discussed:
TSY agar, MacConkey’s agar, Mannitol Salt agar, Blood agar
Biological concepts:
Normal flora, bacterial colonies, hemolysis, Gram-positive and Gram-negative bacteria
Laboratory context:
Teaching laboratory
Associated organisms:
Staphylococcus, Streptococcus, Enterobacteriaceae
Intended audience:
Students enrolled in a microbiology laboratory course
Temporal context:
Multi-week laboratory sequence
Instructional purpose:
Observation and analysis of bacterial growth on culture media
Year:
2026
Institution:
University of Leicester
College:
College of Life Sciences
School/Department:
LeMID
Funding:
CLS / HPRU Grant studentship
First Supervisor:
Prof Julie Morrissey
Second Supervisor:
Dr Emma Marczylo, UK Health Security Agency (UKHSA)
Additional Supervisors:
Kate Jones, Health and Safety Executive; Emma-Jane Goode
Project Type:
PhD research project
Field:
Microbiology / Public Health
Focus:
Metal exposure, bacterial persistence, antimicrobial resistance
Target Organisms:
Staphylococcus aureus (CA-MRSA and HA-MRSA)
Training Provided:
Molecular microbiology, tissue culture, omics, microscopy
Collaborating Organizations:
Health Protection Research Unit, National Institute of Health Research (NIHR), Health and Safety Executive, UKHSA
Authors:
Vivianne J Goosens; Kenneth T Walker; Silvia M Aragon; Amritpal Singh; Vivek R Senthivel; Linda Dekker; Joaquin Caro-Astorga; Marianne L A Buat; Wenzhe Song; Koon-Yang Lee; Tom Ellis
Corresponding author:
Tom Ellis
Affiliation:
Imperial College Centre for Synthetic Biology, Imperial College London, London SW7 2AZ, UK
Note:
Affiliation
Department of Bioengineering, Imperial College London, London SW7 2AZ, UK
Institution:
Imperial College London
Field:
Synthetic biology; Engineered Living Materials; bacterial cellulose; modular cloning
Organisms:
Komagataeibacter rhaeticus; Komagataeibacter xylinus; Komagataeibacter hansenii; Escherichia coli
Methodology:
Golden Gate DNA assembly; Type IIS restriction enzymes; modular plasmid-based cloning
System described:
Komagataeibacter Tool Kit (KTK)
Application:
Multigene construct assembly and programmed protein secretion in cellulose-producing bacteria
Document type:
Scientific research article
Research focus:
Development and demonstration of a hierarchical modular cloning toolkit for cellulose-producing bacteria
Year:
2023
Region / City:
Salt Lake City, Utah, United States
Subject:
Bacterial diversity, chemical ecology, natural products
Document Type:
Scientific Research Paper
Organization / Institution:
University of Utah, Scripps Institution of Oceanography, University of California at San Diego
Author:
Elijah R. Bring Horvath, William J. Brazelton, Min Cheol Kim, Reiko Cullum, Matthew A. Mulvey, William Fenical, Jaclyn M. Winter
Target Audience:
Researchers in microbiology, marine biology, and chemical ecology
Period of Validity:
N/A
Approval Date:
N/A
Date of Changes:
N/A
Year:
2018
Region / City:
Not specified
Topic:
Gene expression in biofilm and planktonic bacteria
Document type:
Scientific article
Organization / Institution:
Not specified
Author:
Not specified
Target audience:
Researchers in microbiology and molecular biology
Effective period:
Not specified
Approval date:
Not specified
Modification date:
Not specified
Year:
2023
Region / city:
Shanghai, China; Poznan, Poland
Subject:
Molecular biology, Genetic engineering
Document type:
Research paper
Institution:
Shanghai Jiao Tong University, Poznan University of Technology
Author:
Liyun Jia, Shuo Xu, Yue Zhang, Muhammad Bilal, Hairong Cheng
Target audience:
Researchers in molecular biology, genetic engineering, and microbiology
Validity period:
Not specified
Approval date:
Not specified
Date of changes:
Not specified
Year:
2023
Region / City:
Jiangsu, China
Topic:
Environmental Science, Agriculture
Document Type:
Research Article
Organization / Institution:
Jiangsu Academy of Agricultural Sciences, Jiangsu University, Jinan University, Yancheng Institute of Technology
Authors:
Pei Chen, Yu Cheng, Ning Wang, Jian-Guang Yu, Zhao Ying, Li-Hong Xue
Target Audience:
Academics, Environmental Scientists, Agricultural Researchers
Period of validity:
N/A
Approval Date:
N/A
Date of changes:
N/A
Year:
2026
Region / City:
Brazil
Theme:
Antimicrobial Resistance, Cannabidiol, Molecular Docking
Document Type:
Research Article
Institution:
Federal University Of Minas Gerais
Authors:
Leonardo Ferreira Oliveira, Alessandro Soares Fonseca de Matos, Nayara Gonçalves Pereira, Adriana Froes do Nascimento Souto, Agueda Maria de França Tavares, Franciane Gabrielle dos Santos, Ageu Emerson Braz do Carmo, Suze Adriane Fonseca, Joao Bosco de Souza Júnior, Lorena Bianca Chaves Barbosa, Sabrina Ferreira Simões do Nascimento, Meriane Gonçalves Resende, Ana Elisa Lelis de Oliveira, Maria Júlia Ribeiro Magalhães
Target Audience:
Researchers, Scientists, Healthcare professionals
Period of Application:
Ongoing
Approval Date:
Not specified
Date of Modifications:
Not specified
Year:
2026
Region / City:
Mediterranean Sea
Theme:
Quorum sensing, Quorum quenching, Microbiology
Document type:
Research Supplementary Material
Author:
Not specified
Target audience:
Researchers, Microbiologists
Action period:
Not specified
Approval date:
Not specified
Modification date:
Not specified
Keywords:
Quorum sensing, Quorum quenching, Bacteria, Metagenomics, Mediterranean Sea
Description:
A research supplement containing detailed data on the prevalence of quorum sensing and quorum quenching activity in marine bacteria from the Mediterranean Sea.
Subject:
Microbiology
Topic:
Bacterial cell wall structure and alteration
Document Type:
Scientific explanatory article
Biological Focus:
Protoplasts, spheroplasts, and L-forms
Key Structures:
Peptidoglycan, cytoplasmic membrane, outer membrane, periplasm
Organisms Mentioned:
Bacillus; Clostridium; Haemophilus; Pseudomonas; Staphylococcus; Vibrio; Listeria; Mycoplasma; Rickettsiae; Chlamydiae
Experimental Methods:
Lysozyme treatment; cell wall-active antibiotics; osmotic stabilization
Concepts Addressed:
Gram-positive bacteria; Gram-negative bacteria; membrane structure; osmotic balance; genetic material transfer
Research Context:
Laboratory induction of cell wall-deficient forms; membrane fusion studies; protein localization in Gram-negative bacteria
Classification:
Unstable L-forms; Stable L-forms
Year:
Not specified
Region / City:
Not specified
Topic:
Bacterial biology, Gram-negative bacteria, Lipopolysaccharides
Document Type:
Educational Material
Organization / Institution:
Not specified
Author:
Not specified
Target Audience:
Students or professionals in microbiology
Period of Validity:
Not specified
Approval Date:
Not specified
Date of Changes:
Not specified
Journal:
Microbial Ecology
Article title:
Taxonomic dependency of beta diversity for bacteria, archaea and fungi in a semi-arid lake
Authors:
Haijun Yuan; Weizhen Zhang; Huaqun Yin; Runyu Zhang; Jianjun Wang
Corresponding author:
Jianjun Wang ([email protected]
Note:
)
Affiliations:
State Key Laboratory of Lake Science and Environment, Nanjing Institute of Geography and Limnology, Chinese Academy of Sciences, Nanjing, China; State Key Laboratory of Environmental Geochemistry, Institute of Geochemistry, Chinese Academy of Sciences, Guiyang, China; University of Chinese Academy of Sciences, Beijing, China; School of Minerals Processing and Bioengineering, Central South University, Changsha, China; Key Laboratory of Biometallurgy of Ministry of Education, Central South University, Changsha, China
Study area:
Hulun Lake, China
Subject:
Microbial ecology; beta diversity; environmental gradients
Microbial groups:
Bacteria; Archaea; Fungi
Environmental factors:
Water physicochemical variables; Sediment properties
Statistical analyses:
Pearson correlation; Mantel test; Spearman correlation; Linear and quadratic models
Content:
Supplementary tables and figures (Table S1–S2; Fig. S1–S4)
Organization:
Culture Collection of Switzerland (CCOS)
Country:
Switzerland
City:
Wädenswil
Document type:
Agreement and deposition form
Subject:
Deposition of microorganisms in a public strain collection
Scope:
Bacteria, yeasts and fungi up to Risk Group 2
Fields of concentration:
Biocatalysis, biological control, photosynthetic bacteria, diagnostic, food microbiology, research
Risk limitation:
Acceptance limited to organisms up to Risk Group 2
Regulatory framework:
Swiss national and international biosafety regulations
Related legislation:
Bacteriological Code; Convention on Biological Diversity
Collaborating institutions:
Zurich University of Applied Sciences; CTI; Federal Office for the Environment, Berne; Swiss Biotech Association; Swiss Industrial Biocatalysis Consortium; DSMZ, Braunschweig, Germany
Access conditions:
Public availability of strains for a fee
Geographical focus:
Primarily isolates from Switzerland
Requirements for new species:
Deposition of type strain in at least two collections in two different countries
Biosafety classification:
BSL 1 or BSL 2
Required depositor information:
Taxonomical data, strain history, genome data, cultivation conditions, preservation method, pathogen assessment, references
Legal declaration:
Confirmation of rights and non-violation of third-party rights
Signature requirement:
Place, date and signature of the depositor