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Editorial commentary in a medical oncology journal discussing current research, diagnostic challenges, and emerging imaging, endoscopic, and biomarker-based approaches for detecting early-stage pancreatic cancer and its precursor lesions.
Journal:
World Journal of Clinical Oncology
Manuscript number:
97248
Year:
2025
Volume and issue:
16(2)
Document type:
Editorial
Scientific field:
Oncology; Gastroenterology
Topic:
Early diagnosis of pancreatic cancer and precursor lesions
Corresponding author:
Giuseppina Pontillo
Corresponding author affiliation:
Gastroenterology and Endoscopy Unit, Presidio Ospedaliero San Giuseppe Moscati – ASL Caserta, Caserta, Italy
Author affiliations:
Azienda Ospedaliero Universitaria Policlinico di Modena, Modena, Italy; Presidio Ospedaliero San Giuseppe Moscati – ASL Caserta, Caserta, Italy; University of Naples Federico II, Naples, Italy; IRCCS Regina Elena National Cancer Institute, Rome, Italy; Azienda Ospedaliero Universitaria Policlinico “G Rodolico – San Marco”, Catania, Italy
Received date:
May 29, 2024
Revised date:
September 27, 2024
Accepted date:
October 21, 2024
Online publication date:
February 24, 2025
DOI:
10.5306/wjco.v16.i2.97248
URL:
https://www.wjgnet.com/2218-4333/full/v16/i2/97248.htm
Keywords:
Pancreatic cancer; Endoscopic ultrasonography; Endoscopic retrograde cholangiopancreatography; Magnetic resonance cholangiopancreatography; Serial pancreatic-juice aspiration cytologic examination
Related work discussed:
Case report by Furuya et al.
Main subject:
Diagnostic strategies and research perspectives for early detection of pancreatic adenocarcinoma and its precursor lesions
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The product description is provided for reference. Actual content and formatting may differ slightly.
Note:
Year
Topic:
Cancer diagnosis
Document Type:
Audit tool
Target Audience:
Healthcare professionals involved in cancer diagnostics
Contextual description:
A diagnostic audit tool for evaluating and improving the capacity of healthcare services in delivering a timed HPB cancer diagnostic pathway.
Year:
2023
Region / city:
Wellington
Subject:
Pancreatic Cancer, Quality Performance Indicators
Document type:
Technical Specifications
Organization / institution:
Te Aho o Te Kahu
Author:
Te Aho o Te Kahu, Cancer Control Agency, National Pancreatic Cancer Working Group
Target audience:
Analysts, healthcare professionals
Validity period:
Ongoing
Approval date:
February 2021
Date of changes:
Not specified
Year:
2023
Region / city:
Torino, Italy; Valencia, Spain; Faenza, Italy
Topic:
Photodynamic therapy, Metal-organic frameworks, Photochemotherapy
Document Type:
Research Article
Organization / Institution:
University of Torino, Instituto de Tecnología Química, Istituto di Scienza, Tecnologia e Sostenibilità per lo Sviluppo dei Materiali Ceramici (ISSMC-CNR)
Author:
Carlotta Pontremoli, Sergio Rojas Buzo, Silvia De Toni, Kateryna Bondar, Simone Galliano, Herald Paja, Bartolomeo Civalleri, Alessandra Fiorio Pla, Francesca Carla Bonino, Nadia Barbero
Target Audience:
Researchers, Scientists, Medical professionals
Period of Validity:
N/A
Approval Date:
N/A
Modification Date:
N/A
Context:
This research article explores the integration of squaraine-based photosensitizers in hafnium-based metal–organic frameworks (MOFs) for enhanced photodynamic therapy against pancreatic cancer cells.
Year:
2025
Type of document:
Supplementary digital content
Topic:
Computational preoperative risk stratification in pancreatic surgery
Methods:
Radiomics, feature extraction, hierarchical clustering, machine learning models
Patient cohorts:
Dresden (Development), Heidelberg (External Test)
Imaging modality:
CT
Software/Tools:
TotalSegmentator v1.5.6, MIRP v2.0.0
Number of extracted features:
654
Cluster analysis:
Hierarchical agglomerative clustering
Comparison:
AutoFRS vs traditional FRS risk stratification
Content sections:
Patient selection, CT imaging characteristics, Totalsegmentator configuration, MIRP feature extraction, Feature clustering, Radiomics and clinical signatures, Evaluation of models, Web application, Glossary
Year:
2022
Region / City:
UK
Theme:
Pancreatic cancer research
Document type:
Fellowship guidelines
Organization:
Pancreatic Cancer UK
Author:
Pancreatic Cancer UK
Target audience:
Researchers with postdoctoral experience in pancreatic cancer
Period of validity:
2022-2025
Approval date:
Not specified
Date of amendments:
Not specified
Year:
2018
Region / City:
US
Topic:
Pancreatic Cancer Staging and Treatment
Document Type:
Medical Quiz
Organization:
AJCC (American Joint Committee on Cancer)
Author:
Not specified
Target Audience:
Healthcare professionals, particularly those in oncology and radiology
Effective Period:
Not specified
Approval Date:
Not specified
Date of Changes:
Not specified
Year:
2026
Region / city:
Not specified
Topic:
Pancreatic cancer research
Document type:
Supplementary figure legends
Institution:
Not specified
Authors:
Not specified
Target audience:
Researchers in oncology and immunology
Experimental models:
Human PDAC tissue, murine PDAC cells, immunocompromised mice xenografts
Methods:
Immunohistochemistry, flow cytometry, Western blot, sphere formation assay, phagocytosis assay
Markers analyzed:
CD47, CD133, iNOS, Arginase, YM1, CD31
Treatment analyzed:
Anti-CD47 antibody, anti-CD44 antibody, isotype controls
Data presentation:
Kaplan-Meier survival curves, tumor volume measurements, representative images
Cell types studied:
Pancreatic cancer stem cells, macrophages, HPDE, PSC
Time points:
2 h, 12 h, 2 months
Year:
2017
Subject Area:
Biosensing and Enzyme Detection
Keywords:
gelatin film, quartz crystal microbalance, trypsin, amylase, lipase, enzymatic degradation
Type of Document:
Supplementary Materials
Experimental Method:
Quartz Crystal Microbalance (QCM)
Equipment:
Maxtek RQCM (Inficon)
Temperature Conditions:
Approximately 37°C
Flow Rate:
20 μL/min
Test Media:
Air, PBS, PBS with enzymes
Enzyme Concentrations:
0.5 mg/mL and 1 mg/mL
License:
Creative Commons Attribution (CC BY) 4.0
Figures Included:
Figure 1 (a–c)
Measured Parameters:
Gelatin degradation rate, mass change, signal saturation
Field of Application:
Pancreatic enzyme sensing
Year:
2021
Region / City:
Mumbai, India; Philadelphia, PA, USA; Munich, Hamburg, Heidelberg, Germany; Amsterdam, The Netherlands; Graz, Austria; Boston, MA, USA; Athens, Greece; Liverpool, Newcastle upon Tyne, and Glasgow, UK; Belgrade, Serbia; Jacksonville, FL, USA; Dublin, Ireland; Barcelona, Spain; Lyon, France; Nanjing, P.R. China; Rochester, MN, USA; Verona and Milan, Italy
Theme:
Pancreatic surgery, Postoperative complications
Document Type:
Medical research article
Organization / Institution:
International Study Group of Pancreatic Surgery (ISGPS)
Author:
Shailesh V. Shrikhande, Masillamany Sivasanker, Charles M. Vollmer, Helmut Friess, Marc G. Besselink, Abe Fingerhut, Charles J. Yeo, Carlos Fernandez-del Castillo, Christos Dervenis, Christoper Halloran, Dirk J. Gouma, Dejan Radenkovic, Horacio J. Asbun, John P. Neoptolemos, Jakob R. Izbicki, Keith D. Lillemoe, Kevin C. Conlon, Laureano Fernandez-Cruz, Marco Montorsi, Max Bockhorn, Mustapha Adham, Richard Charnley, Ross Carter, Thilo Hackert, Werner Hartwig, Yi Miao, Michael Sarr, Claudio Bassi, Markus W. Büchler
Target Audience:
Surgeons, medical professionals, researchers in pancreatic surgery
Period of validity:
2021-2025
Approval Date:
2021
Date of revisions:
Not specified
Year:
2023
Region / City:
Multi-country (Europe)
Topic:
Cancer epidemiology, lifestyle factors
Document Type:
Research article
Institution:
International Agency for Research on Cancer, EPIC consortium
Authors:
Sabine Naudin, Vivian Viallon, Dana Hashim, Heinz Freisling, Mazda Jenab, Elisabete Weiderpass, Flavie Perrier, Fiona McKenzie, et al.
Study Population:
400,577 cancer-free participants
Follow-up Period:
15 years (median)
Primary Outcome:
Pancreatic cancer incidence
Key Variables:
Healthy lifestyle index, BMI, waist-to-hip ratio, smoking, alcohol intake, diet, physical activity
Statistical Methods:
Cox proportional hazards model, population attributable fraction
Corresponding Author:
Pietro Ferrari
Keywords:
Pancreatic cancer, healthy lifestyle index, EPIC, prospective study
Year:
2026
Institution:
Johns Hopkins Hospital, Asan Medical Center
Study Type:
Molecular biology study
Methods:
Droplet digital PCR, MSP, bisulfite sequencing, ddQMSP, mRNA expression analysis
Biomarkers:
SOX17, ACTB, KRAS, GNAS, seven marker genes
Sample Type:
Surgically aspirated pancreatic cyst fluid, pancreatic cell lines, normal pancreatic tissue
Sample Size:
183 patients (discovery and validation sets)
Pathology:
IPMN, MCN, SCN, HGD, INV, IGD, LGD
Data Presentation:
1-D ddPCR plots, heat maps, AUC values, box plots, correlation plots
Statistical Measures:
Mean ± standard deviation, coefficient of determination (R²), coefficient of variation (% CV), 95% confidence interval
Experimental Conditions:
5-Aza-2′-deoxycytidine, trichostatin A treatment
Comparisons:
Between hospitals (JHH vs AMC), among cyst types, stratified by mutation status and histologic grade
Year:
Not specified
Field:
Cancer Research
Subfield:
Pancreatic Cancer Biology
Research Focus:
Glypican-1 targeting and antibody–drug conjugates
Document Type:
Supplemental Data / Supplementary Methods
Associated Article:
Glypican-1 is a novel target for stroma and tumor cell dual-targeting antibody–drug conjugates in pancreatic cancer
Authors:
Tsujii S et al.
Experimental Methods:
GPC1-knockout cell establishment; flow cytometry; quantitative flow cytometry; internalization assay; fluorescence microscopy; heparinase III treatment; western blot analysis; antibody–drug conjugate preparation; ELISA; cell viability assay
Biological Materials:
Human pancreatic cancer cell lines (BxPC-3, AsPC-1, PANC-1, MiaPaCa-2)
Key Molecular Target:
Glypican-1 (GPC1)
Experimental Techniques:
FACS analysis; fluorescence microscopy; SDS-PAGE; ELISA; hydrophobic interaction chromatography
Purpose:
Description of experimental procedures used to analyze GPC1 expression and evaluate antibody–drug conjugates in pancreatic cancer models
Year:
2024
Region / city:
Beijing, China
Topic:
Pancreatic diseases, oxidative stress, NADPH oxidase
Document type:
Review
Organization / institution:
Chinese PLA General Hospital
Authors:
Ya-Wei Bi, Long-Song Li, Nan Ru, Bo Zhang, Xiao Lei
Target audience:
Researchers, healthcare professionals in gastroenterology and oncology
Effective period:
Not specified
Approval date:
Not specified
Date of changes:
Not specified
Year:
2023
Region / City:
Not specified
Topic:
Pancreatic Cancer, Medical Diagnosis
Document Type:
Medical Quiz
Institution:
Not specified
Author:
Not specified
Target Audience:
Medical professionals, healthcare students
Period of Validity:
Not specified
Approval Date:
Not specified
Date of Changes:
Not specified
Year:
2017
Region / City:
Hyderabad, India
Topic:
Gastroenterology, Pancreatic fluid collections
Document type:
Journal article, Review
Organization / Institution:
Asian Institute of Gastroenterology
Author:
Zaheer Nabi, Jahangeer Basha, D Nageshwar Reddy
Journal:
World Journal of Gastroenterology
ISSN:
1007-9327
Publisher:
Baishideng Publishing Group Inc.
DOI:
http://dx.doi.org/10.3748/wjg.v23.i15.2660
URL:
http://www.wjgnet.com/1007-9327/full/v23/i15/2660.htm
Keywords:
Endotherapy, Pseudocyst, Pancreatic necrosis, Necrosectomy
Publication date:
April 21, 2017
Received:
January 3, 2017
Revised:
February 27, 2017
Accepted:
March 21, 2017
Open Access:
CC BY-NC 4.0
Target audience:
Gastroenterologists, medical researchers
Abstract:
Review of recent advances and controversies in endoscopic management of pancreatic fluid collections, including differentiation of collection types, techniques, devices, and multidisciplinary approaches.
Year:
2023
Region / City:
Global
Topic:
Tuberculosis, Healthcare, Public Health
Document Type:
Research Review
Organization / Institution:
Not specified
Author:
Not specified
Target Audience:
Healthcare providers, Researchers, Public health professionals
Period of Action:
Not specified
Approval Date:
Not specified
Date of Changes:
Not specified
Document type:
Guidelines
Program:
BRAIN Initiative
Purpose:
Advancement of scientific and technical merit through inclusivity
Applicable to:
Grant applications responding to Funding Opportunity Announcements
Attachment type:
Other Attachment
Length:
1 page
Scope:
Scientific, technical, and workforce diversity in research
Key elements:
Strategies and rationales; timeline and milestones; progress assessment approaches
Focus areas:
Project leadership and team; training and mentoring; partnerships; study participants; publications
Target audience:
Principal investigators, co-investigators, research teams, grant applicants
Source type:
Funding application guidance
Year:
1787–1790
Region:
United States
Topic:
Constitution ratification debates
Document type:
Educational DBQ source
Author:
Various historical figures and newspapers
Institutions:
State conventions, newspapers
Key figures:
George Washington, Mercy Otis Warren
Audience:
Students, researchers of U.S. history
Period covered:
1787–1790
Primary sources:
Newspaper articles, letters, convention records
Year:
2023
Region / City:
Africa
Topic:
Human Rights, Development, African Charter
Document Type:
Chapter
Organization / Institution:
Office of the United Nations High Commissioner for Human Rights (OHCHR), University for Peace (UPEACE), United Nations University – International Institute for Global Health (UNU-IIGH)
Author:
Patrice Vahard
Target Audience:
Students, Human Rights Professionals, Academics
Period of Effectiveness:
Ongoing
Approval Date:
2023
Date of Changes:
N/A