№ files_lp_4_process_2_48653
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Supplementary figure captions describing laboratory measurements of oxidative stress, antioxidant gene regulation, and apoptosis markers in IDH1-mutant glioma cells and glioma stem cell lines using biochemical assays, imaging, and gene knockdown experiments.
Year: Not specified
Scientific Field: Molecular Biology; Cancer Biology
Research Topic: Reactive oxygen species regulation and antioxidant response in IDH1-mutant glioma cells
Document Type: Supplementary figure captions
Experimental Models: U251 cells; GSC827; GSC923; TS603; mouse model
Genes / Proteins: IDH1; Nrf2 (NFE2L2); GCLC; GCLM; SLC7A11; caspase-3
Cellular Processes: Mitochondrial ROS production; apoptosis; antioxidant response
Experimental Methods: Western blot; MitoSOX immunofluorescence imaging; real-time PCR; ROS-Glo assay; GSH/GSSG assay; Annexin-PI flow cytometry
Treatments / Reagents: doxycycline (DOX); mannitol; catalase; MnTBAP; brusatol; N-acetylcysteine (NAC)
Genetic Manipulation: siRNA knockdown of Nrf2, GCLC, and GCLM
Measured Outcomes: ROS levels; mRNA expression; protein expression; glutathione balance; apoptotic cell fraction; mouse body weight
Statistical Indicators: ** p < 0.01; *** p < 0.001
Price: 8 / 10 USD
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Addendum to the submission for Dabrafenib and Trametinib for the treatment of paediatric low-grade and high-grade glioma with BRAF V600E mutation
Year: 2023
Region / City: Australia
Theme: Paediatric Oncology, Pharmacology
Document Type: Medical Submission
Organization / Institution: Novartis Pharmaceuticals Australia Pty Limited
Author: Novartis Pharmaceuticals Australia Pty Limited
Target Audience: Medical practitioners, oncologists, pharmacists, healthcare providers
Period of Validity: Not specified
Approval Date: 6 December 2023
Date of Amendments: Not specified
Precision Neuro-Oncology: A Comprehensive Review of Molecular Diagnostics and Therapies in Glioma Care
Year: 2023
Region / City: N/A
Topic: Oncology, Neurology
Document Type: Review Article
Organization: Asian Oncology Research Journal
Author: Hadeel Mahdi Hussein
Target Audience: Scientific community, researchers, oncologists
Period of Action: N/A
Date of Approval: N/A
Date of Changes: N/A
Ethical Issues: None mentioned
References: Sufficient and recent
Language Quality: Suitable for scholarly communications
Context: Review article focusing on molecular diagnostics and therapies for glioma care in the field of neuro-oncology.
Inhibition of glioma cells’ proliferation by doxorubicin-loaded exosomes via microfluidics
Year: 2026
Region / City: Hong Kong SAR
Subject: Neuroscience, Biomedical Sciences, Drug Delivery
Document Type: Research Article
Organization / Institution: City University of Hong Kong
Author: Abhimanyu Thakur, Rakesh Kumar Sidu, Heng Zou, Md Kowsar Alam, Mengsu Yang, Youngjin Lee
Target Audience: Researchers, Scientists, Medical Professionals
Period of Validity: N/A
Approval Date: N/A
Modification Date: N/A
Topics: IDH1-Mutant U251 glioma