№ files_lp_4_process_2_83293
File format: docx
Character count: 1483
File size: 3076 KB
Year:
2023
Region / City:
N/A
Topic:
Oncology, Neurology
Document Type:
Review Article
Organization:
Asian Oncology Research Journal
Author:
Hadeel Mahdi Hussein
Target Audience:
Scientific community, researchers, oncologists
Period of Action:
N/A
Date of Approval:
N/A
Date of Changes:
N/A
Ethical Issues:
None mentioned
References:
Sufficient and recent
Language Quality:
Suitable for scholarly communications
Context:
Review article focusing on molecular diagnostics and therapies for glioma care in the field of neuro-oncology.
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The product description is provided for reference. Actual content and formatting may differ slightly.
Year:
2023
Region / City:
Australia
Theme:
Paediatric Oncology, Pharmacology
Document Type:
Medical Submission
Organization / Institution:
Novartis Pharmaceuticals Australia Pty Limited
Author:
Novartis Pharmaceuticals Australia Pty Limited
Target Audience:
Medical practitioners, oncologists, pharmacists, healthcare providers
Period of Validity:
Not specified
Approval Date:
6 December 2023
Date of Amendments:
Not specified
Year:
Not specified
Scientific Field:
Molecular Biology; Cancer Biology
Research Topic:
Reactive oxygen species regulation and antioxidant response in IDH1-mutant glioma cells
Document Type:
Supplementary figure captions
Experimental Models:
U251 cells; GSC827; GSC923; TS603; mouse model
Genes / Proteins:
IDH1; Nrf2 (NFE2L2); GCLC; GCLM; SLC7A11; caspase-3
Cellular Processes:
Mitochondrial ROS production; apoptosis; antioxidant response
Experimental Methods:
Western blot; MitoSOX immunofluorescence imaging; real-time PCR; ROS-Glo assay; GSH/GSSG assay; Annexin-PI flow cytometry
Treatments / Reagents:
doxycycline (DOX); mannitol; catalase; MnTBAP; brusatol; N-acetylcysteine (NAC)
Genetic Manipulation:
siRNA knockdown of Nrf2, GCLC, and GCLM
Measured Outcomes:
ROS levels; mRNA expression; protein expression; glutathione balance; apoptotic cell fraction; mouse body weight
Statistical Indicators:
** p < 0.01; *** p < 0.001
Year:
2026
Region / City:
Hong Kong SAR
Subject:
Neuroscience, Biomedical Sciences, Drug Delivery
Document Type:
Research Article
Organization / Institution:
City University of Hong Kong
Author:
Abhimanyu Thakur, Rakesh Kumar Sidu, Heng Zou, Md Kowsar Alam, Mengsu Yang, Youngjin Lee
Target Audience:
Researchers, Scientists, Medical Professionals
Period of Validity:
N/A
Approval Date:
N/A
Modification Date:
N/A
Note:
Year
Topic:
Precision Medicine
Document Type:
Agreement
Institution:
University of Bern
Target Audience:
Doctoral candidates, Supervisors, Mentors
Year:
2021
Region / city:
N/A
Document type:
Research supplementary materials
Organization / institution:
University of North Carolina
Author:
Ling Xie, Ryan N. Sheehy, Yan Xiong, Adil Muneer, John A. Wrobel, Kwang-Su Park, Julia Velez, Jing Liu, Yan-Jia Luo, Ya-Dong Li, Luis Quintanilla, Yongyi Li, Chongchong Xu, Mohanish Deshmukh, Zhexing Wen, Jian Jin, Juan Song, Xian Chen
Target audience:
Researchers in neuroscience, pharmacology, and precision medicine
Period of validity:
N/A
Approval date:
N/A
Date of amendments:
N/A
Year:
2025
Region / city:
Zurich
Theme:
Oncology, Clinical Trials
Document Type:
Funding Proposal
Institution:
University of Zurich, CCCZ
Author:
N/A
Target Audience:
Researchers, Investigators, Clinical Trials Applicants
Validity Period:
2025
Approval Date:
N/A
Date of Changes:
N/A
Context:
Detailed proposal outline for a research funding call for investigator-initiated clinical trials in oncology, including project description, team structure, cost estimate, and timelines.
Year:
2023
Region / City:
United States
Topic:
Deployment and Installation Plan
Document Type:
Guide
Organization / Institution:
Department of Veterans Affairs
Author:
VetsEZ
Target Audience:
Clients, stakeholders, and support personnel involved in the deployment and management of EPSI
Period of Validity:
N/A
Approval Date:
N/A
Date of Changes:
April 7, 2023
Note:
Version History
Description:
Detailed guide for the deployment, installation, back-out, and rollback procedures for the EPSI software, outlining roles, responsibilities, and required resources for a smooth transition and deployment.
Year:
2025
Date of Event Which Requires Filing of this Statement:
October 31, 2025
Amendment Number:
3
Issuing Authority:
Securities and Exchange Commission
Type of Document:
Schedule 13G filing
Governing Law:
Securities Exchange Act of 1934
Issuer:
Praxis Precision Medicines, Inc.
Issuer Address:
99 High Street, 30th Floor, Boston, MA 02110
Title of Class of Securities:
Common Stock, par value $0.0001 per share
CUSIP Number:
74006W207
Outstanding Shares Referenced:
24,693,005
Reporting Persons:
Adage Capital Management, L.P.; Robert Atchinson; Phillip Gross
Place of Organization:
Delaware
Citizenship:
United States
Business Address of Reporting Persons:
200 Clarendon Street, 52nd Floor, Boston, Massachusetts 02116
Aggregate Amount Beneficially Owned:
1,305,175 shares
Percent of Class Represented:
5.29%
Filing Category:
Rule 13d-1
SEC File References:
Prospectus filed pursuant to Rule 424(b)(5) on October 20, 2025; Current Report on Form 8-K filed October 20, 2025
Year:
2019
Region / City:
Millville, NJ
Theme:
Shooting Sports
Document Type:
Event Announcement
Organization:
Cumberland Riflemen, Inc.
Author:
Gregory Warde
Target Audience:
Shooting sports enthusiasts, club members, and the general public
Period of Activity:
September 26, 2019
Date of Approval:
Not specified
Date of Changes:
Not specified
Competition Rules:
Current NRA Conventional Pistol Rules
Course of Fire:
50yd NMC
Award Type:
Cash prizes based on entry fees
Entry Fee:
$30 for full match, $25 for two guns
Registration:
Via njpitols.net
Location of Event:
Cumberland Riflemen Range, Millville, NJ
Pre-match Briefing:
8:45 AM
Firing Start Time:
9:00 AM
Alcohol Policy:
Prohibited before and during the match
General Information:
Lavatory facilities available, bring own drinking water, short break between matches
Contact Information:
Gregory Warde, [email protected]
Note:
, (856) 265-9520
Directions to Range:
Detailed directions provided from various routes
Year:
2026
Region / City:
Not specified
Subject:
Educational methods, Literacy, Spelling
Document Type:
Instructional template
Organization / Institution:
Not specified
Author:
Not specified
Target Audience:
Educators, Tutors, Parents
Duration of Use:
Daily practice sessions
Date Created:
Not specified
Measurement Method:
Number of words read or written correctly per minute
Format:
Printable one-page sheets with grids for tracking progress
Organization:
PRECISION/EXPEDITED
Address:
28482 Airoso Street, Rancho Mission Viejo, CA 92675
Standard:
ISO 9001:2015
Document Type:
Quality Manual
System:
Quality Management System (QMS)
Methodology:
Plan-Do-Check-Act (PDCA)
Scope:
Quality management system processes and controls
Leadership:
William R. Towery, President
Policy:
Quality Policy focused on customer satisfaction and continual improvement
Structure:
Sections aligned with ISO 9001:2015 clauses (Context, Leadership, Planning, Support, Operation, Performance Evaluation, Improvement)
Application:
Precision parts manufacturing and expedited services
Source Type:
Corporate quality management documentation
Corporate quality management manual outlining the structure, policies, processes, and responsibilities of an ISO 9001:
2015-compliant quality management system for precision parts manufacturing and expedited services.
Year:
2021
Region / city:
Cairo, Egypt
Topic:
Pediatric urology, neurogenic bladder dysfunction, kidney disease
Document type:
Research article, review
Author:
Mohamed Wishahi
Target audience:
Medical professionals, researchers in urology and nephrology
Period of validity:
Ongoing, research based on articles up to March 10, 2021
Date of approval:
July 22, 2021
Date of revisions:
June 16, 2021
Date of publication:
July 25, 2021
Year:
2026
Institution:
Korea Advanced Institute of Science and Technology (KAIST)
Location:
Korea
Speaker/Author:
Jungwon Kim
Email:
[email protected]
Field:
Optical frequency combs, photonics, precision timing
Document type:
Lecture abstract / conference presentation
Target audience:
Researchers and engineers in photonics and ultrafast science
Topics covered:
Mode-locked fiber lasers, silica micro-combs, ultralow-noise timing, laser-RF-THz synchronization, on-chip clock distribution, time-of-flight sensors, 3D dynamic imaging, microwave/mm-wave generation
Professional affiliations:
Fellow of Optica, Senior Member of IEEE, Topical Editor of Optics Letters
Recognition:
2024 IEEE Photonics Society Distinguished Lecturer
Date:
14 December 2018
Location:
Het Nieuwe Instituut, Museumpark 25, 3015 CB Rotterdam
Additional location:
Erasmus University, Burgemeester Oudlaan 50, 3062 PA Rotterdam
Event type:
Scientific symposium program
Main theme:
High Precision Radiotherapy
Occasion:
Inauguration of Prof. Dr. M. S. Hoogeman
Organizing institution:
Erasmus MC Rotterdam
Moderator (morning):
Prof. Dr. B. Heijmen, Erasmus MC Rotterdam
Moderator (afternoon):
Prof. Dr. M. van Vulpen, HollandPTC Delft
Participating institutions:
Erasmus MC Rotterdam; LUMC Leiden; HollandPTC Delft; Maastro Maastricht; Delft University of Technology; VUmc Amsterdam
Topics:
Molecular Radiomics; Biological Image Guided Radiotherapy; Automation in Radiotherapy; Proton Therapy; Artificial Intelligence in Radiotherapy; Robust Proton Therapy
Program structure:
Lectures, discussions, lunch, inauguration ceremony
Company:
AMADA GmbH
Product name:
ORSUS-3015AJe
Industry sector:
Metalworking machinery
Product category:
High speed precision laser cutting machine
Power range:
3–8 kW
Key technologies:
Automatic Mode Converter; Laser Integration System (LIS); AMNC 4ie Controller; i-CAS; V-factory; IoT compatibility; Mobile HMI
Headquarters of group:
Japan
Founder:
Isamu Amada
Year founded:
1946
European presence:
More than 40 years
Production facilities in Europe:
4 plants
Press contact:
Kathrin Soroka-Morzinietz
Address:
Amada Allee 1, 42781 Haan, Germany
Telephone:
+49 2104 2126-311
Email:
[email protected]
Website:
www.amada.de
Year:
2015
Location:
Herborn, Hessen, Germany
Topic:
Data centre cooling and energy efficiency
Document type:
Press release
Organization:
Rittal GmbH & Co. KG
Authors:
Kerstin Ginsberg, Hans-Robert Koch
Target audience:
IT and data centre managers
Period of relevance:
June 2015
Approval date:
9 June 2015
Standards compliance:
European directives 2006/42EG, 2006/95EG, 2004/108EG, 97/23EG
Technical specifications:
Heat dissipation up to 167 kW, EC motors, scroll compressors, compatibility with indirect free cooling systems
Product models:
CRAC CW, CRAC DX, CRAC INV DX
Production:
Fully assembled at factory with functional test