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A comprehensive meta-analysis of randomized controlled trials comparing various beta-blockers used to treat hypertension, evaluating their effects on blood pressure and related cardiovascular outcomes.
Year:
2023
Region / city:
Athens, Greece; Milan, Italy
Topic:
Beta-blockers, hypertension
Document type:
Meta-analysis, Scientific research article
Organization / institution:
Department of Cardiology, Helena Venizelou Hospital, Evangelismos General Hospital of Athens, University Milano-Bicocca, Policlinico di Monza
Author:
Costas Thomopoulos, George Bazoukis, Costas Tsioufis, Giuseppe Mancia
Target audience:
Medical professionals, researchers in cardiology and pharmacology
Period of validity:
N/A
Approval date:
N/A
Modification date:
N/A
Price: 8 / 10 USD
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The product description is provided for reference. Actual content and formatting may differ slightly.
Year:
2024
Regulatory authority:
Therapeutic Goods Administration (TGA)
Medicine:
MACITENTAN 10 mg with TADALAFIL 40 mg (Opsynvi®)
Indication:
Pulmonary arterial hypertension (PAH), WHO Group 1, functional class II and III
Therapy type:
Dual or triple combination therapy
Dosage form:
Tablet, fixed dose combination (FDC)
Prescriber type:
Medical practitioners
Restriction type:
Authority Required (Written, Complex Authority Required)
Clinical criteria:
Treatment as dual therapy (MAC+TAD) or triple therapy with prostanoid
Population:
Adult patients with stable PAH on separate doses of macitentan and tadalafil
Previous considerations:
PBAC recommendations for macitentan and tadalafil since 2011–2014
Approval date:
16 September 2024
Source documents:
TGA registration, PBAC meeting minutes, ACM minutes August 2024, FDA, EMA, CDA references
Year:
2021
Region / city:
Australian Capital Territory
Topic:
Hypertension, Pregnancy, Maternity Care
Document Type:
Guideline
Author:
Canberra Health Services
Target Audience:
Medical officers, Registered Midwives, Nurses, Allied Health professionals, Students working under supervision
Period of Validity:
Not specified
Approval Date:
Not specified
Date of Changes:
Not specified
Year:
2023
Region / City:
Not specified
Topic:
Postpartum hypertension, clinical trials, remote monitoring
Document Type:
Research Article
Organization / Institution:
Not specified
Authors:
Adi Hirshberg, Katheryne Downes, Sindhu Srinivas
Target Audience:
Researchers, healthcare professionals
Period of validity:
Not specified
Approval Date:
Not specified
Date of changes:
Not specified
Year:
2025
Region / City:
Japan
Topic:
Hypertension Research
Document Type:
Form
Institution / Organization:
Japanese Society of Hypertension
Author:
Not specified
Target Audience:
Researchers and medical professionals
Period of Action:
2025
Approval Date:
Not specified
Date of Changes:
Not specified
Note:
Year
Topic:
Clinical trial, Idiopathic Intracranial Hypertension (IIH), vision preservation
Document type:
Participant Information Sheet
Organization / institution:
University of Birmingham
Target audience:
Adults with Idiopathic Intracranial Hypertension (IIH)
Year:
2023
Region / City:
England
Theme:
Healthcare / Clinical Coding
Document Type:
Technical Specification
Organization / Institution:
NHS England
Author:
General Practice Specification and Extraction Service (GPSES), NHS England
Target Audience:
GPES users, GP system suppliers
Effective Period:
2023/2024/2425
Approval Date:
01/04/2023
Amendment Date:
01/04/2024
Note:
Year
Topic:
Endocrine hypertension, primary aldosteronism
Document type:
Position statement
Organization / institution:
European Society of Hypertension, Japan Endocrine Society, Taiwan Society of Aldosteronism
Author:
Paolo Mulatero, Leonardo Sechi, Tracy Ann Williams, Jacques W.M. Lenders, Martin Reincke, Fumitoshi Satoh, Andrzej Januszewicz, Mitsuhide Naruse, Michael Doumas, Franco Veglio, Vin Cent Wu, Jiri Widimsky
Target audience:
Healthcare professionals, researchers in endocrinology and hypertension
Year:
2010-2024
Region / city:
Asia-Pacific
Subject:
Hepatology
Document Type:
Clinical Practice Guidelines
Organization / Institution:
Asian Pacific Association for the Study of the Liver (APASL)
Author:
APASL
Target Audience:
Healthcare professionals
Period of validity:
2010-2024
Date of approval:
2010
Date of revisions:
2024
Context:
Collection of clinical practice guidelines and consensus statements issued by the Asian Pacific Association for the Study of the Liver on various hepatological conditions, including hepatocellular carcinoma, hepatitis B and C, liver transplantation, and metabolic diseases.
Year:
2021
Region / City:
Bangalore, India
Topic:
Medical case report, Dengue in pregnancy
Document type:
Case Report
Institution:
Manipal Hospitals, Bangalore, India
Author:
Dr. Supriya Preman T P, Dr. Nirmal Sheshagiri
Target Audience:
Healthcare professionals, Obstetricians, Intensive care specialists
Period of validity:
N/A
Approval date:
N/A
Date of changes:
N/A
Note:
Contextual description
Year:
2023
Region / city:
Livingstone, Zambia; Lusaka, Zambia; Twickenham, London, UK; Nashville, TN, USA
Subject:
Hypertension, dietary salt, inflammation
Document type:
Research study
Organization / institution:
Mulungushi University, University of Zambia, St. Mary’s University, Vanderbilt University Medical Center
Author:
Sepiso K. Masenga, Leta Pilic, Benson M. Hamooya, Selestine Nzala, Geoffrey Kwenda, Douglas C. Heimburger, Wilbroad Mutale, John R. Koethe, Annet Kirabo, Sody M. Munsaka
Target audience:
Researchers, healthcare professionals
Period of validity:
Not specified
Approval date:
Not specified
Modification date:
Not specified
Year:
2023
Region / city:
United States
Topic:
Hypertension management
Document type:
News report
Organization:
OSF HealthCare
Author:
Not specified
Target audience:
General public
Date of approval:
Not specified
Date of changes:
Not specified
Year:
2026
Region / City:
Baghdad
Topic:
Pharmacology, Hypertension
Document Type:
Educational material
Institution:
College of Dentistry, Baghdad University
Author:
Dr. Zainab Ghalib
Target Audience:
Medical students, healthcare professionals
Period of validity:
Ongoing
Approval Date:
2026-02-23
Date of Changes:
Not specified
Description:
This document provides an overview of hypertension, its classification, pathophysiology, and pharmacological treatments, with a focus on antihypertensive agents and their mechanisms of action.
Year:
2021–2023
Country:
United States
Topic:
Hypertension control and cardiovascular risk
Type of document:
Health news article
Organization:
OSF HealthCare
Author / Speaker:
Jason Trager, DO
Data source:
National Health and Nutrition Examination Survey (NHANES)
Medical field:
Cardiology
Key subjects:
Blood pressure guidelines, lifestyle modification, medication adherence, cardiovascular prevention
Referenced period:
National Heart Month
Geographic focus:
Bloomington, Illinois
Clinical thresholds discussed:
130/80 mm Hg and 140/90 mm Hg
Preventive measures mentioned:
Smoking cessation, DASH diet, exercise, weight loss, sleep apnea treatment, coronary artery calcium scan
Year:
2002
Region / City:
Kathmandu, Nepal
Topic:
Health, Hypertension, Patient Perception, Treatment Adherence
Document Type:
Research Instrument
Organization:
Not specified
Author:
Not specified
Target Audience:
Patients with Hypertension
Period of Validity:
Not specified
Approval Date:
Not specified
Modification Date:
Not specified
Year:
2019
Region / Country:
Australia
Subject:
Pulmonary arterial hypertension medicines and subsidy policy
Document Type:
Policy review agenda item and briefing
Institution:
Pharmaceutical Benefits Advisory Committee (PBAC)
Program:
Pharmaceutical Benefits Scheme (PBS)
Topic:
Post-Market Review (PMR) of PAH medicines
Medicines Mentioned:
bosentan, ambrisentan, macitentan, sildenafil, tadalafil, iloprost, riociguat, epoprostenol
Medical Classification Referenced:
WHO Functional Class II–IV pulmonary arterial hypertension
Guidelines Referenced:
2015 European Society of Cardiology / European Respiratory Society Guidelines for the diagnosis and treatment of pulmonary hypertension
Stakeholders:
PAH Reference Group, medicine sponsors including Actelion, GlaxoSmithKline, and Pfizer
Regulatory Focus:
Revision of PBS prescribing restrictions and subsidy conditions
Key Policy Changes Considered:
Extension of subsidised monotherapy to WHO Functional Class II patients, updated PAH definition, inclusion of additional WHO Group 1 PAH subtypes, removal of calcium channel blocker trial requirement, strengthened diagnostic role of right heart catheterisation
Consultation Process:
Pre-PBAC consultation with sponsors and reference group
Associated Meetings:
PBAC meetings in November 2018, March 2019, and planned July 2019 review discussion
Related Policy Activity:
Planned stakeholder meeting on PAH combination therapy scheduled for May 2019
Organization:
Joanna Briggs Institute (JBI)
Document type:
Critical appraisal tool / checklist
Topic:
Randomized controlled trials (RCTs)
Target audience:
Researchers conducting systematic reviews
Year:
2020
Source:
JBI Manual for Evidence Synthesis
Format:
Checklist for individual participants in parallel group RCTs
Purpose:
Assess methodological quality and risk of bias in RCTs
Reference:
Tufanaru C, Munn Z, Aromataris E, Campbell J, Hopp L. Chapter 3: Systematic reviews of effectiveness
Year:
2019
Note:
Region / city
Topic:
Risk of bias assessment, randomized trials
Document type:
Template
Organization / institution:
Cochrane Collaboration
Author:
Julian PT Higgins, Jelena Savović, Matthew J Page, Jonathan AC Sterne
Target audience:
Researchers, clinicians, trialists
Note:
Year
Target Audience:
Statisticians and Principal Investigators responsible for preparation of DSMB reports
Year:
2020
Region / City:
South Australia
Topic:
Systematic Reviews, Critical Appraisal, Healthcare Research
Document Type:
Research Guideline
Institution:
University of Adelaide, JBI
Author:
Tufanaru C, Munn Z, Aromataris E, Campbell J, Hopp L
Target Audience:
Researchers, Healthcare Professionals
Period of Application:
Not specified
Approval Date:
Not specified
Date of Modifications:
Not specified
Year:
2021
Region / City:
Seattle
Subject:
Oncology, Cardiology
Document Type:
Clinical Protocol
Author:
Kasey Leger, MD
Target Audience:
Medical Professionals, Researchers
Period of Validity:
Ongoing
Approval Date:
2021
Date of Last Update:
2021