№ files_lp_3_process_7_032567
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Multi-centre clinical trial protocol and governance summary outlining design, eligibility criteria, interventions, regulatory requirements, and data protection provisions for a UK randomised controlled study of treatments for new onset atrial fibrillation in intensive care units.
Acronym: ABBRUPT
Organ / Institution: University of Birmingham
Unit: Birmingham Clinical Trials Unit (BCTU)
Trial Office: ABBRUPT Trial Office
Country: United Kingdom
Regulatory Framework: UK Data Protection Regulations
Policy Framework: UK Policy Framework for Health and Social Care Research
Trial Design: Pragmatic open-label interventional multi-centre two-arm randomised controlled trial with internal pilot and economic evaluation
Objectives: To compare clinical and cost effectiveness of beta blockers versus amiodarone for new onset atrial fibrillation in intensive care and to conduct cost-effectiveness and cost-utility analyses at 90-day follow-up
Target Population: Patients aged 16 years and over in intensive care units with new onset atrial fibrillation
Sample Size: 2560 patients
Setting: At least 60 intensive care units across the UK
Interventions: Amiodarone versus beta blockers (including bisoprolol, metoprolol, esmolol, propranolol, atenolol, labetalol, carvedilol, landiolol)
Primary Outcome: 90-day mortality
Secondary Outcomes: Clinical and economic outcomes including ICU and hospital measures
Eligibility Criteria: Defined inclusion and exclusion criteria for patients with new onset atrial fibrillation in ICU
Data Management: Contact details retained indefinitely on a BCTU database and subject to written request under UK Data Protection Regulations
Oversight Requirements: Approval required from relevant Trust or Health Board Management prior to patient consent
Consent Requirements: Written informed consent and participant information sheet on Trust/Health Board headed paper
Local Governance: Compliance with Good Clinical Practice and UK Policy Framework for Health and Social Care Research
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mTOR inhibition enhances the antitumor efficacy of RAF dimer-MEK blockade by inhibiting the ATF4-MTHFD2 pathway
Note: Year
Supplementary Results for Intra-tumoral Injection of Caerin 1.1 and 1.9 Peptides in Vaccinated TC-1 Tumour Bearing Mice with PD-1 Blockade
Year: 2026
Research Area: Immunology, Cancer Biology
Document Type: Scientific Article Supplementary Data
Authors: Guoying Ni et al.
Organ / Institution: Not specified
Experimental Model: TC-1 tumour-bearing mice
Treatments: Caerin 1.1/1.9 peptides, P3, PD-1 blockade
Cell Types Studied: Macrophages, B cells, NK cells, Dendritic cells, T cells
Methods: Single-cell RNA sequencing, GO and KEGG enrichment analysis
Key Findings: Modulation of immune cell populations and activation pathways in tumour microenvironment
Supplementary Figures: 13A-F, 14A-F
Standard Operating Procedure for Amiodarone Hydrochloride
Department: Not specified
Date SOP was written: Not specified
Date SOP was approved by PI/Lab Supervisor: Not specified
Principal Investigator: Not specified
Internal Lab Safety Coordinator/Lab Manager: Not specified
Institution: University of Georgia
Chemical Name: Amiodarone hydrochloride
CAS Number: 19774-82-4
Molecular Formula: C25H29I2NO3·HCl
Chemical Class: Irritant, Toxic
Physical State: Solid
Recommended Storage Temperature: 2–8 °C
Type of SOP: Hazardous Chemical
Related Policy Documents: UGA Chemical and Laboratory Safety Manual; UGA Respiratory Protection Plan
Emergency Contact Procedures: Dial 911; Campus emergency numbers provided
Intended Use: Laboratory handling and safety compliance
Topics: ABBRUPT blockade Amiodarone