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Letter to the editor analyzing a case of hepatitis B virus reactivation in a patient receiving tyrosine kinase inhibitors and reviewing existing literature on HBVr risk in oncological settings.
Journal: World Journal of Gastroenterology
Manuscript NO: 90838
Manuscript Type: Letter to the Editor
Authors: Francesca Colapietro, Nicola Pugliese, Antonio Voza, Alessio Aghemo, Stella De Nicola
Affiliations: Department of Biomedical Sciences, Humanitas University, Milan, Italy; Division of Internal Medicine and Hepatology, Department of Gastroenterology, Humanitas Research Hospital, Milan, Italy; Department of Emergency, Humanitas Research Hospital, Milan, Italy
Corresponding Author: Francesca Colapietro, MD, Department of Biomedical Sciences, Humanitas University, Milan, Italy, [email protected]
Received: December 15, 2023
Revised: January 11, 2024
Accepted: February 18, 2024
Keywords: Chronic hepatitis B, Reactivation, Nucleoside analogue, Tyrosine kinase inhibitors, Onco-hematology
Study Type: Case report and literature review
Patient Details: 67-year-old Caucasian male with chronic lymphocytic leukemia, HBsAg-/anti-HBc+
Treatment: Tyrosine kinase inhibitors, specifically acalabrutinib
Clinical Outcome: HBV reactivation with liver failure, treated with nucleos(t)ide analogues
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Topics: oncological tyrosine REACTIVATION