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This research investigates the predictive value of polygenic risk scores (PRS) in assessing the risk for glaucoma-related factors such as intraocular pressure and vertical cup to disc ratio, using large cohort data from multiple studies.
Year:
2023
Region / city:
Australia
Field:
Ophthalmology, Genetics
Document type:
Research Article
Institution:
QIMR Berghofer Medical Research Institute, University of Queensland, The University of Western Australia, Massachusetts Institute of Technology, Queensland University of Technology, University of Tasmania, University of Melbourne
Author:
Weixiong He, Samantha Sze-Yee Lee, Santiago Diaz Torres, Xikun Han, Puya Gharahkhani, Michael Hunter, Chandrakumar Balartnasingam, Jamie Craig, Alex W Hewitt, David A Mackey, Stuart MacGregor
Target Audience:
Researchers, Healthcare professionals
Period:
2023
Date approved:
N/A
Date of changes:
N/A
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Year:
2023
Region / City:
United States
Topic:
Genomics, Genetics
Document Type:
Research Paper
Organization / Institution:
Rutgers University, NIH
Author:
Matteo Di Vincenzo, Thanavadee Prachason, Gaia Sampogna, Angelo Arias-Magnasco, Bochao Danae Lin, Lotta-Katrin Pries, Jim van Os, Bart P.F. Rutten, Ran Barzilay, Andrea Fiorillo, Sinan Guloksuz
Target Audience:
Researchers, Geneticists, Biologists
Period of Activity:
2023
Date of Approval:
N/A
Date of Changes:
N/A
Year:
Not specified
Country / Region:
Republic of Korea
Academic field:
Epidemiology; Genetics; Sports science; Neurology
Topic:
Relationship between physical activity and stroke incidence considering genetic risk
Document type:
Scientific research article
Data source:
Korean Genome and Epidemiology Study
Methodology:
Genome-wide association study (GWAS) and polygenic risk score (PRS) analysis
Key variables:
Physical activity, stroke incidence, single nucleotide polymorphisms (SNPs), polygenic risk score
Institutions:
Seoul National University; CHA University; Hallym University; Waseda University
Corresponding author:
Hyo Youl Moon
First author:
Yun Seo Cho
Authors:
Yun Seo Cho; Tae Yeon Kim; Kihoon Yuk; Ji Eun Lee; Joo Hee Park; Yeon Soo Kim; Min-Chul Lee; Jin Pyeong Jeon; In cheol Jeong; Kumpei Tanisawa; Hyo Youl Moon
Population studied:
Participants of the Korean Genome and Epidemiology Study
Research focus:
Differences in stroke incidence according to levels of physical activity and genetic predisposition
Keywords:
Stroke; Genome Wide Association Study; Single Nucleotide Polymorphism; Polygenic Risk Score; Physical activity
Note:
Year
Contextual description:
A scientific paper presenting supplementary methods related to polygenic analysis and causal inference in the relationship between loneliness, isolation, and schizophrenia.
Year:
2020
Region / city:
USA
Theme:
Ophthalmology, Medical Risk Management
Document type:
Risk Management Recommendations
Organization:
OMIC
Author:
Anne M. Menke, RN, PhD
Target audience:
Ophthalmologists
Effective period:
Ongoing
Approval date:
8/4/20
Date of changes:
None specified
Section:
Supplemental Materials
Abbreviations:
IOP; MEE/RHC; QC; GSA; PCA; LD; MAF; PC; WES; BAM; VCF; EUR; AFR; AMR; EAS; SAS; GQ; SNPs; MAD; GTEx; Non-PAR; Indels; HWE; AB; GWAS; FAME; GC; QTL; eQTL; CLPP; FDR; OHTN; RINT
Methodology:
Whole exome sequencing and statistical genetic analysis
Sequencing Platform:
NovaSeq S4 flow cell (2x151bp)
Library Preparation Kit:
KAPA Hyper Prep with Library Amplification Primer Mix (KK8504)
Capture Kit:
IDT XGen hybridization and wash kit
Custom Bait:
TWIST Biosciences exome bait
Liquid Handling Systems:
Agilent Bravo; Hamilton Starlet
Quantification Method:
qPCR; Invitrogen Quant-It broad range dsDNA assay
Genotyping Platform:
Global Screening Array (GSA)
Software:
PLINK 1.9; PLINK 2.0; R; Python; Hail v0.2
Reference Panel:
1000 Genomes Project Phase 3
Ancestry Groups:
European (EUR); African (AFR); Admixed American (AMR); East Asian (EAS); South Asian (SAS)
Statistical Analysis:
Analysis of variance (aov in R); Tukey honest significant difference test
Quality Control Criteria:
Sample-level and variant-level QC including genotype missingness, heterozygosity, relatedness (PI_HAT), sex concordance, ancestry inference, BAM and VCF metrics
Year:
2023
Journal:
Journal of Cataract & Refractive Surgery
DOI:
10.1097/j.jcrs.0000000000001055
Authors:
Jascha A. Wendelstein; Sarah Hinterberger; Peter C. Hoffmann; Nino Hirnschall; Michael J. Koss; Achim Langenbucher; Paul Jirak; Matthias Bolz
Institutions:
Johannes Kepler University Linz; Kepler University Hospital GmbH; Saarland University; IROC Zürich; Augen- und Laserklinik Castrop-Rauxel; Augenzentrum Nymphenburger Höfe München; EyeLaser Clinic Linz
Region:
Linz, Austria
Study Period:
2014–2020
Submission Date:
November 22, 2021
Acceptance Date:
August 30, 2022
Study Design:
Single-center, single-surgeon retrospective consecutive case series
Sample Size:
91 eyes of 91 patients
Population:
Middle European patients undergoing myopic phakic intraocular lens implantation
Intervention:
Visian Implantable Collamer Lens (ICL) model V4c implantation
Comparative Methods:
OCOS software; JPhakic software; Olsen-Feingold formula; Holladay formula; Linz-Homburg-Castrop formula
Outcome Measures:
Mean and median absolute prediction error; percentage of eyes within 0.25 D, 0.5 D, 0.75 D, and 1.0 D
Ethics Approval:
EK 1074/2021, JKU ethics committee Linz
Publisher:
Wolters Kluwer on behalf of ASCRS and ESCRS
Copyright Year:
2022
Year:
2018
Region / City:
Depew, NY
Topic:
Corneal hysteresis, intraocular pressure, glaucoma
Document Type:
Guideline Note
Organization / Institution:
VbBS, HERC
Author:
Not specified
Target Audience:
Ophthalmologists, healthcare professionals
Effective Period:
Not specified
Approval Date:
November 2014
Modification Date:
Not specified
Year:
2026
Study Type:
Clinical survey
Region / City:
Not specified
Topic:
Ophthalmology, intraocular lenses
Document Type:
Supplementary tables
Institution:
Not specified
Authors:
Not specified
Target Population:
Patients with intraocular lenses
Questionnaires Included:
NAVQ, CATQUEST-9SF, Dysphotopsia, Spectacle dependence
Number of IOL types surveyed:
4
Data Presentation:
Number of responses per question
Year:
2026
Region:
Asia
Subject:
Ophthalmology, Intraocular Lens Calculation
Document Type:
Supplementary Material
Institution:
Department of Ophthalmology, Medical Research Center
Authors:
Jinchul Kim, Joonsung Park, Yoonjung Jo
Sample Size:
Short eyes N=134, Medium eyes N=2833, Long eyes N=133
Formulas Evaluated:
PEARL, PEARL-rCMAL, HTCL, Kane, EVO 2.0, HTAL, HSAL, HSCL, Barrett, Hoffer QST, Holladay 1, Hoffer Q, SRK/T
Metrics Reported:
ME, SD, RMSE, MedAE, MAE, Percentage within 0.50 D
Optimized Constants:
Provided for all formulas including Hoffer Q, Holladay 1, SRK/T, Haigis variants, PEARL, Kane, EVO 2.0, Barrett
Data Analysis Methods:
Root mean square error comparisons, heteroscedastic test, Holm correction, Cochran’s Q test, pairwise McNemar test
Axial Length Categories:
Short (<22 mm), Medium (22–26 mm), Long (>26 mm)
Year:
2021
Region / City:
N/A
Topic:
Personality Styles
Document Type:
Podcast
Organization:
Wiley
Author:
Dr. Mark Scullard
Target Audience:
Individuals interested in DiSC personality assessments
Period of Effect:
N/A
Approval Date:
N/A
Date of Changes:
N/A
Note:
Year
Subject:
Parking Disc Application
Document Type:
Form
Organization:
University of Cape Town (UCT)
Author:
UCT Traffic Office
Target Audience:
UCT Staff and Third Parties
Effective Period:
Annual renewal
Year:
2026
Region / City:
Lawrence, Kansas
Subject:
Sports, Club Organization
Document Type:
Constitution
Organization:
KU Disc Golf Club
Author:
KU Disc Golf Club Officers
Target Audience:
University of Kansas students
Period of Validity:
Ongoing
Approval Date:
Not specified
Amendment Date:
Not specified
Name:
Anna Brownd
Profession:
Disc Jockey (DJ)
Objective:
To obtain a disc jockey position to further develop professional skills and experience
Years of Experience:
Over 6 years
Education:
Postgraduate Diploma
Institution:
Merrowley Bootcamp
Education Period:
Jan 2015 - Dec 2016
Professional Experience:
Disc Jockey (DJ), RTM Entertainment, Feb 2017 - Feb 2019
Note:
Professional Experience
Event DJ, RX30, Mar 2014 - Jan 2017
Skills:
Midi controllers, Networking, Online performance, Remixes and Mashups, Beatmatching, Phrasing, EQing, Gain Control
Responsibilities:
Musical programming, song mixing, audience engagement, sound level control, event entertainment, record maintenance
Contact Information:
Cell (123) 456 7890, Home (123) 456 7890, Email [email protected]
Address:
123 Anywhere Street, Any City
Portfolio:
resumesbot.com
Field:
Creative, Media and Arts
Document Type:
Curriculum Vitae
Year:
2021
Organization:
Wiley / Everything DiSC
Document type:
FAQ
Topic:
DiSC® assessment, Catalyst™ platform, emotional intelligence, management and leadership concepts
Target audience:
Employees, managers, facilitators
Content update date:
11/18/2021
Related materials:
Everything DiSC Research Report, Everything DiSC Manual, Catalyst™ Facilitation Kit
Assessment tools:
Everything DiSC on Catalyst™ assessment, Agile EQ™ measurement
Purpose:
Explanation of concepts, validity, and practical application of Everything DiSC on Catalyst™
Year:
2015-2016
Organization:
Irish Flying Disc Association
Document Type:
Policy Document
Scope:
National Teams in Ultimate and Flying Disc Sports
Version:
5
Date of Initial Version:
25/10/2010
Date of Latest Version:
TBC
Responsible Body:
IFDA Committee
Target Audience:
Coaches, Players, Team Managers, National Selection Boards
Content Includes:
Governance, Team Selection, Coach and Player Codes of Conduct
Related Appendices:
Appendix A - Coaches Code of Conduct, Appendix B - Player Code of Conduct
Source Type:
Official organizational policy document
Year:
2021
Region / city:
Not specified
Subject:
Neuro-ophthalmology, Optical Coherence Tomography, Papilledema
Document type:
Research article
Organization / institution:
J Neuro-Ophthalmology
Author:
Sibony et al
Target audience:
Medical professionals, particularly those in neuro-ophthalmology
Effective period:
Not specified
Approval date:
Not specified
Date of modifications:
Not specified