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This document outlines experimental methodologies for conducting whole-exome sequencing, TP53 genotype analysis, and various functional assays using liver organoids, including cell culture, genomic techniques, and staining protocols.
Year: 2023
Region / City: N/A
Subject: Genomic analysis, liver organoids
Document Type: Research Methodology
Organization / Institution: N/A
Author: N/A
Target Audience: Researchers, genomic scientists
Period of Validity: N/A
Approval Date: N/A
Date of Changes: N/A
Price: 8 / 10 USD
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Supplementary Table 1 Single-nucleotide variations by whole-exome sequencing analysis
Year: 2023
Region / City: Not specified
Topic: Single-nucleotide variations, whole-exome sequencing
Document type: Table
Author: Not specified
Target audience: Researchers, geneticists
Period of validity: Not applicable
Approval date: Not specified
Date of changes: Not specified
Data sources: NCBI, GRCh37
Contextual description: A table listing single-nucleotide variations identified by whole-exome sequencing for various genes.
Supplementary Tables and Data from Study on TP53 Mutations and HLA Restrictions
Year: 2021
Region / City: International
Topic: Cancer Research
Document Type: Supplementary Data
Institution: Not specified
Author: Not specified
Target Audience: Researchers in cancer immunotherapy
Period of Validity: Not specified
Approval Date: Not specified
Date of Changes: Not specified
Supporting Information on TP53 Mutations and Methylation Panels in GC Patients
Year: 2026
Region / City: Not specified
Subject: TP53 mutations, DNA methylation, GC patients
Document Type: Supplementary material
Institution: Not specified
Author: Not specified
Target Audience: Researchers and clinicians in molecular genetics and oncology
Methods: Sanger sequencing, pyrosequencing, primer design
Data Source: Patient tumor samples
Genomic Reference: GRCh37: Genome Reference Consortium human build 37
Figures Included: Methylation distribution and survival analysis
Tables Included: Primer sequences, TP53 mutations
Clinical Context: Neoadjuvant and adjuvant chemotherapy subgroups
Supplemental Figure 1. Differential immune cell score analysis by TP53 and HRD status, stratified by estrogen receptor status
Year: 2026
Region / City: N/A
Topic: Immune cell score analysis, TP53 mutation, HRD status, estrogen receptor status
Document type: Figure
Organization / Institution: N/A
Author: N/A
Target audience: Researchers, medical professionals
Period of validity: N/A
Approval date: N/A
Date of modifications: N/A
Il-17 Signaling in Primary Sclerosing Cholangitis Patient-Derived Organoids
Year: 2023
Region / City: N/A
Subject: Primary Sclerosing Cholangitis, IL-17 Signaling
Document Type: Research Article
Organization / Institution: Mayo Clinic
Author: Ana Sofia Garcia Moreno, Maria Eugenia Guicciardi, Alexander Q. Wixom, Erik Jessen, Jingchun Yang, Sumera I. Ilyas, Jackie K. Bianchi, Filippo Pinto e Vairo, Konstantinos N. Lazaridis, Gregory J. Gores
Target Audience: Researchers, Healthcare professionals, Scientific community
Period of Validity: N/A
Date of Approval: N/A
Date of Changes: N/A
Supplementary Data: Comparison of DNA and RNA Isolation Efficiency in A549 Cell Line, Patient-Derived Organoids, and Pleural Effusion Using Adapted QIAamp® DNA FFPE Tissue Kit
Year: 2023
Region / City: Not specified
Topic: DNA and RNA isolation protocols
Document Type: Supplementary Data
Author: Not specified
Target Audience: Researchers in molecular biology and genomics
Period of Action: Not specified
Approval Date: Not specified
Date of Changes: Not specified
Differentiation of hESCs to Cerebral Organoids
Year: Not specified
Region / City: Not specified
Topic: Stem cell differentiation, Cerebral organoids
Document Type: Protocol
Organization / Institution: Not specified
Author: Madeline Lancaster
Target Audience: Researchers in stem cell biology
Duration: Not specified
Approval Date: Not specified
Date of Changes: Not specified
ENGINEERING EXTRACELLULAR VESICLES OF HUMAN INDUCED PLURIPOTENT STEM CELL-DERIVED BRAIN ORGANOIDS IN STATIC AND DYNAMIC SYSTEMS
Year: 2024
Region / City: United States
Topic: Stem Cell Therapy, Extracellular Vesicles, Brain Organoids
Document Type: Dissertation
Institution: Department of Chemical and Biomedical Engineering
Author: Chang Liu
Advisor: Dr. Yan Li
Target Audience: Researchers in Regenerative Medicine, Neuroscience
Period of Validity: N/A
Approval Date: N/A
Modification Date: N/A
Correlation between patient-derived intestinal organoids and clinical responses to CFTR modulators in people with cystic fibrosis homozygous for F508del
Authors: Noelia Rodriguez Mier; Senne Cuyx; Kris De Boeck; Marijke Proesmans; Mieke Boon; Lieven Dupont; Kaline Arnauts; Elke De Wachter; Stephanie Van Biervliet; Monique Lequesne; Vicky Nowé; Hedwige Boboli; Anabela Santo Ramalho; François Vermeulen; on behalf of the Belgian Organoid Project
Affiliations: KU Leuven; University Hospital Leuven; University Hospital Brussels; Ghent University Hospital; Antwerp University Hospital; GZA Hospital; CHR Citadelle
Country: Belgium
Research field: Cystic fibrosis; CFTR modulators; organoid research; personalized medicine
Study population: 60 people with cystic fibrosis homozygous for F508del
Genetic focus: F508del CFTR mutation (homozygous)
Interventions studied: Elexacaftor/tezacaftor/ivacaftor; Tezacaftor/ivacaftor
Methods: Patient-derived intestinal organoids from rectal biopsies; forskolin-induced swelling assay; comparison with clinical outcomes
Clinical outcomes assessed: Lung function; sweat chloride levels; body weight; pulmonary exacerbations
Type of document: Scientific research article
Source: PubMed
DOI / Identifier: 40883119
CSIRO Postdoctoral Fellowship in Intestinal Organoids to Investigate Host-Microbial Interactions
Year: 2026
Region / City: Adelaide, SA
Subject: Microbiome, Health, Biosecurity, Research Career Development
Document Type: Job Description
Organization / Institution: CSIRO
Author: CSIRO Human Resources
Target Audience: Australian/New Zealand Citizens, Australian Permanent Residents, Australian Temporary Residents
Effective Period: 3 years full-time
Approval Date: Not specified
Modification Date: Not specified
From Organoids to Gastruloids: Selected Resources and Research Links 2019
Year: 2019
Type of document: Curated resource list
Topic: Organoids, Gastruloids, Stem Cell Research
Source/Institution: Royal Society of Biology, EuroStemCell, MRC, Johns Hopkins University, Cell Press
Format: Online articles, videos, blog posts
Audience: Students, educators, researchers
Content scope: Examples of organoids, ethical discussions, induced pluripotent stem cells, 3D organoid models, Wnt/β-Catenin signaling
Topics: whole-exome TP53 Organoids