№ files_lp_4_process_3_082398
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Experimental study detailing in vitro and in vivo methods to investigate the effects of JAK signaling inhibition on fibroblast activation and fibrosis development in systemic sclerosis, including quantitative gene expression, protein analysis, and histological evaluation.
Year:
2026
Region / City:
Not specified
Subject:
Cellular and molecular mechanisms of fibrosis
Document Type:
Research article / Experimental study
Institution:
Not specified
Authors:
Not specified
Target Audience:
Biomedical researchers, clinicians
Experimental Models:
Human dermal fibroblasts, mouse models of fibrosis
Techniques:
Cell culture, qPCR, immunohistochemistry, Western blot, histology
Treatment Agents:
TG101209, 17-DMAG, Ruxolitinib, TGFβ
Disease Focus:
Systemic sclerosis (SSc)
Fibrosis Assessment Methods:
Masson’s Trichrome, Pico-Sirius Red, Ashcroft scoring
Cellular Markers:
αSMA, pJAK1, pJAK2
Data Analysis Software:
ImageJ, MxPro 3005P
Price: 8 / 10 USD
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The product description is provided for reference. Actual content and formatting may differ slightly.
Year:
Not specified
Region / City:
Not specified
Subject:
Biotechnology, Growth Factors
Document Type:
Product Information
Institution:
Not specified
Author:
Not specified
Target Audience:
Researchers, Laboratory Technicians
Validity Period:
Not specified
Approval Date:
Not specified
Modification Date:
Not specified
Context:
Product information sheet for recombinant human fibroblast growth factor 2 (rhFGF2), detailing its properties, specifications, and uses in cell culture systems.
Year:
2015
Region / City:
OECD
Topic:
Endocrine disruption, Aromatase inhibition, Reproductive dysfunction in fish
Document Type:
Review report
Organization / Institution:
OECD
Author:
Not specified
Target Audience:
Researchers, Environmental regulators, Toxicologists
Period of validity:
Not specified
Approval Date:
Not specified
Date of revisions:
September 2015
Year:
2023
Region / City:
Prague, Czech Republic
Topic:
Functional movement disorders, neurophysiology
Document Type:
Research article
Author:
Zuzana Hanzlíková, Markus Kofler, Matěj Slovák, Gabriela Věchetová, Anna Fečíková, David Kemlink, Tomáš Sieger, Evžen Růžička, Josep Valls-Solé, Mark J. Edwards, Tereza Serranová
Target Audience:
Researchers, healthcare professionals in neurology and psychiatry
Period of validity:
N/A
Date of approval:
N/A
Date of changes:
N/A
Year:
2023
Region / City:
Tianjin, Shijiazhuang, Wuhan
Topic:
Catalytic nanocomposite, chemodynamic therapy, hypoxic tumor
Document Type:
Research paper
Organization / Institution:
Nankai University, Hebei Medical University, Huazhong University of Science and Technology, Sichuan University, HeBei Ex&Invivo Biotechnology Co. Ltd
Author:
Yiran Zhang, Hongzhi Hu, Xiangtian Deng, Qingcheng Song, Xin Xing, Weijian Liu, Yingze Zhang
Target Audience:
Researchers, medical professionals
Period of validity:
N/A
Approval Date:
N/A
Modification Date:
N/A
Note:
Contextual Description
Year:
2023
Region / City:
Not specified
Topic:
Immunology, Malaria, Clinical Trials
Document Type:
Research Review
Organization / Institution:
Not specified
Author:
Henrique Borges da Silva
Target Audience:
Researchers, Clinicians
Period of Validity:
Not specified
Approval Date:
Not specified
Modification Date:
Not specified
Year:
2026
Region / City:
Not specified
Topic:
Biomedical research, antifungal coatings
Document Type:
Research article
Institution / Organization:
Not specified
Author:
Not specified
Target Audience:
Researchers, biomedical engineers, healthcare professionals
Period of Validity:
Not specified
Approval Date:
Not specified
Date of Changes:
Not specified
Year:
2021
Region / City:
Rome, Italy
Field:
Cancer Research
Document Type:
Article
Organization / Institution:
Sapienza University of Rome, University of Milan, Consiglio Nazionale delle Ricerche (CNR), University of Trento, University of Ferrara
Authors:
Guerriero, Claudia; Manfredelli, Marianna; Matera, Carlo; Iuzzolino, Angela; Conti, Luciano; Dallanoce, Clelia; De Amici, Marco; Trisciuoglio, Daniela; Tata, Ada Maria
Target Audience:
Researchers in Cancer Biology
Period of Validity:
N/A
Approval Date:
N/A
Modification Date:
N/A
Keywords:
glioblastoma; cancer stem cells; M2 muscarinic receptor; orthosteric and dualsteric muscarinic agonism; autophagy; apoptosis; mTORC1
Funding:
Ateneo Sapienza Funds
References:
Aoki H, 2008, Autophagy, V4, P467, DOI 10.4161/auto.5668
Context:
Scientific article exploring the role of M2 muscarinic receptor stimulation in inducing autophagy and apoptosis in glioblastoma cancer stem cells, and the differential effects of orthosteric and dualsteric agonists.
Year:
2021
Region / City:
Zhejiang Province, China
Topic:
Epilepsy, Neuroscience
Document Type:
Research Article
Organization / Institution:
Zhejiang University
Author:
Lin Zhou, Liang Zhou, Li-Da Su, Sheng-Long Cao, Ya-Jun Xie, Ying Shen
Target Audience:
Researchers in neuroscience and epilepsy
Period of Action:
Not specified
Approval Date:
Not specified
Date of Changes:
Not specified
Year:
2026
Region / City:
International / Multiple research institutions
Subject:
Cancer immunotherapy, tumor microenvironment
Document type:
Supplementary scientific data
Institution:
University of Southampton, Genkyotex SA, La Jolla Institute for Allergy & Immunology, University of Toronto, University of Kent
Authors:
Kirsty Ford, Christopher J. Hanley, Massimiliano Mellone, Cedric Szyndralewiez, Freddy Heitz, Philippe Wiesel, Oliver Wood, Maria Machado, Monette Lopez, Anusha-Preethi Ganesan, Chuan Wang, Ankur Chakravarthy, Tim Fenton, Emma V. King, Pandurangan Vijayanand, Christian H. Ottensmeier, Aymen Al-Shamkhani, Natalia Savelyeva, Gareth J. Thomas
Target audience:
Researchers in oncology and immunology
Data type:
Figures, tables, and experimental results
Methods:
Q-PCR, immunofluorescence, IHC, RNA sequencing, gene network analysis
Experimental models:
Murine syngeneic tumors, TC1, MC38, 4T1, BALBneuT breast tumors
Treatment tested:
NOX4 inhibition, TGF-β1 inhibition, αPD-1, αCTLA-4, macrophage depletion
Key focus:
CAF-mediated CD8 T-cell exclusion, tumor growth modulation, immunotherapy response
Supplementary content:
Figures S1–S6, Tables S1–S2
Year:
2026
Organism studied:
Staphylococcus aureus, Pseudomonas aeruginosa
Substance tested:
Benzalconium chloride
Concentrations:
10x, 100x, 1000x, 30 kg m-3
Control:
Sterile water
Temperature:
35 °C
Observation period:
3 days
Type of document:
Scientific figure description
Field:
Microbiology / Antimicrobial study
Year:
2009–2014
Region:
International / multiple study sites
Topic:
Cognitive psychology; autism spectrum disorders
Document type:
Supplementary material
Institution:
University or research laboratories conducting the cited studies
Authors:
Geurts et al., Mullane et al., and other cited researchers
Target audience:
Cognitive psychologists, neuroscientists, ASD researchers
Tasks described:
Eriksen flanker, Stroop, Simon, SNARC, Navon, antisaccade, remote distractor, illogical rule
Data type:
Reaction time (RT) costs, error costs, experimental protocols
Sample characteristics:
Participants with ASD and healthy controls
Study period:
Various studies conducted between 1999 and 2014
Publication references:
Geurts et al., 2014; Mullane et al., 2009; Christ et al., 2007, 2011; Dichter & Belger, 2007, 2008; others listed in Table A1
Analysis methods:
Qualitative review, quantitative meta-analysis, experimental task performance measurement
Note:
Year
Theme:
Microbiology
Document type:
Research figure
Target audience:
Researchers
Context description:
Visual representation of experimental data on the inhibition of fungal growth under different concentrations of a substance.
Year:
Not specified
Scientific field:
Molecular biology; cancer research
Research topic:
CHK1 inhibition and DNA polymerase interaction in cancer cells
Document type:
Supplementary figures and experimental data description
Biological materials:
Human NSCLC and colorectal cancer cell lines
Cell lines:
A549, SW620, NCI-H1975, Calu-6, HCT116, RKO, NCI-H460, HBEC3-KT
Key genes / proteins:
CHK1, POLA1, POLE, POLE2, RPA32, H2AX, GAPDH
Experimental methods:
SRB assay, siRNA knockdown, western blot analysis, fluorescence microscopy, linear regression analysis
Chemical compounds:
SRA737, MK-8776, aphidicolin, gemcitabine, CD437, DMSO
Statistical analysis:
Student’s t-test, Chou–Talalay method, linear regression
Measured outcomes:
GI50 values, cell proliferation, protein expression levels, replication stress markers, phosphorylation of RPA32, H2AX foci formation
Experimental design:
Drug treatment and gene knockdown assays in cultured human cancer cell lines
Sample size:
Biological replicates typically n ≥ 2–3
Purpose:
Analysis of synthetic lethality and drug interaction effects involving CHK1 inhibition and DNA polymerase activity
Year:
2026
Region / City:
Hong Kong SAR
Subject:
Neuroscience, Biomedical Sciences, Drug Delivery
Document Type:
Research Article
Organization / Institution:
City University of Hong Kong
Author:
Abhimanyu Thakur, Rakesh Kumar Sidu, Heng Zou, Md Kowsar Alam, Mengsu Yang, Youngjin Lee
Target Audience:
Researchers, Scientists, Medical Professionals
Period of Validity:
N/A
Approval Date:
N/A
Modification Date:
N/A
Note:
Year
Topic:
Pharmacokinetics, Ibrutinib, CYP3A Inhibition
Document Type:
Research Paper
Authors:
Eric D. Eisenmann, Qiang Fu, Elizabeth M. Muhowski, Yan Jin, Muhammad Erfan Uddin, Dominique A. Garrison, Robert H. Weber, Jennifer Woyach, John C. Byrd, Alex Sparreboom, Sharyn D. Baker
Target Audience:
Researchers, Pharmacologists, Healthcare Professionals
Context:
A research paper analyzing the intentional modulation of ibrutinib pharmacokinetics through CYP3A inhibition, including experimental methods and data on the effects of ketoconazole and cobicistat.