№ files_lp_4_process_3_073632
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Supplementary tables presenting pharmacogenetic and clinical data from multiple pazopanib trials include patient characteristics, genotypes, liver enzyme elevations, and statistical associations.
Year:
2026
Region / City:
Multicenter, international
Topic:
Pharmacogenetics, oncology, hepatotoxicity
Document type:
Supplementary data tables
Institution:
Pharmaceutical research consortium
Author:
Multiple clinical investigators
Target population:
Patients with various cancers receiving pazopanib
Study phases:
I–III clinical trials
Total participants:
3,190
Genetic focus:
HLA-B*57:01, rs1800625, UGT1A1 variants
Primary tumors:
Renal cell carcinoma, ovarian cancer, soft tissue sarcoma, and others
Endpoints:
ALT elevation, DILI, Hy’s Law assessment
Data collection period:
Various, corresponding to each trial
Statistical measures:
Odds ratio, hazard ratio, confidence interval, P values
Analytical methods:
Pharmacogenetic association, sensitivity analyses, GWAS
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The product description is provided for reference. Actual content and formatting may differ slightly.
Year:
2022
Region / City:
Maryland
Topic:
Pre-eclampsia, Magnesium toxicity
Document Type:
Case Study
Institution:
Carroll Community College
Author:
Christine Schlaerth, PhD, RN, CNM, WHNP-BC
Target Audience:
Nursing students, healthcare professionals
Period of validity:
N/A
Approval Date:
N/A
Date of modification:
N/A
Year:
2023
Region / City:
Minnesota
Topic:
Effluent Toxicity Testing
Document Type:
Report
Organization / Institution:
Minnesota Pollution Control Agency (MPCA)
Author:
Minnesota Pollution Control Agency (MPCA)
Target Audience:
Environmental regulators, facility operators, testing laboratories
Period of Effectiveness:
Ongoing (based on NPDES permit)
Approval Date:
Not specified
Modification Date:
Not specified
Year:
Not specified
Region / City:
Not specified
Theme:
Bacterial Protein Synthesis Inhibitors, Antibiotics
Document Type:
Research Article / Scientific Paper
Organ / Institution:
Not specified
Author:
Adimula Sharon Ebere
Target Audience:
Medical professionals, researchers
Period of Validity:
Not specified
Approval Date:
Not specified
Date of Changes:
Not specified
Year:
2023
Region / City:
Malaysia
Topic:
Life cycle toxicity assessment of wastewater treatment
Document Type:
Research article
Institution:
University of Southampton
Author:
Siti Safirah Rashid, Yong-Qiang Liu
Target Audience:
Researchers, environmental engineers, policy makers
Period of validity:
Not specified
Date of approval:
Not specified
Date of changes:
Not specified
Year:
2017
Region / city:
Victoria, ACT
Topic:
Drug safety, harm reduction
Document type:
Advisory notice
Organization:
Harm Reduction Victoria
Author:
Not specified
Target audience:
Public, drug users, healthcare professionals
Effective date:
Not specified
Date of approval:
Not specified
Date of amendments:
Not specified
Context:
Warning about the presence of dangerous synthetic drugs 25C-NBOMe and 4-FA sold as ‘2C-B’, with information on their adverse effects and harm reduction.
Year:
2023
Region / City:
Ohio, USA
Topic:
Nanotechnology, RNA Nanoparticles, Cancer Targeting
Document Type:
Research Article
Organization / Institution:
The Ohio State University, Wexner Medical Center
Author:
Hongzhi Wang, Chiran Ghimire, Hui Li, Mario Vieweger, Congcong Xu, Peixuan Guo
Target Audience:
Researchers, Scientists, Medical Professionals
Period of Validity:
N/A
Approval Date:
N/A
Date of Changes:
N/A
Note:
Context
Year:
2018
Region / city:
Alfred, NY
Subject:
Biology, Biochemistry
Document type:
Research article
Organization / institution:
Alfred University, Department of Biology
Author:
Geoffrey Lippa
Target audience:
Students in biological sciences
Period of validity:
N/A
Date of approval:
N/A
Date of changes:
N/A
Year:
2002
Product name:
Abine (Abamectina 1.8% p/v)
Active substance:
Abamectin
Study type:
Acute oral toxicity study; Acute dermal toxicity study
Test guidelines:
OECD No. 423; OECD No. 402
GLP compliance:
Yes
Laboratory:
Jai Research Foundation
Location:
Valvada 396 108; Gujarat; India
Author:
Aldrin Joseph, S.
Document numbers:
JRF 3719; JFR 3720
Test species:
Rat (Wistar)
Sex:
Male and female
Route of administration:
Oral (gavage); Dermal (semi-occlusive, 24 h)
Dose levels:
200, 500, 2000 mg/kg bw (oral); 2000 mg/kg bw (dermal)
Oral LD50:
500–2000 mg/kg bw
Dermal LD50:
> 2000 mg/kg bw
Observation period:
14 days
Regulatory references:
Directive 2001/59/EC; Regulation (EC) 1272/2008; Council Directive 67/548/EC
Hazard classification:
R22 (Harmful if swallowed); H302 (Harmful if swallowed); H318 (Causes serious eye damage)
Year:
2021
Region / City:
Makassar
Subject:
Environmental Science, Marine Biology
Document Type:
Research Article
Organization:
University of Fajar, Faculty of Engineering
Author:
Ismail Marzuki, Iksan Ashari, Andi Asdar Marzuki, Anggi Angela
Target Audience:
Academics, Researchers, Environmental Scientists
Period of Validity:
Not applicable
Approval Date:
Not specified
Date of Revision:
Not specified
Year:
2023
Region / City:
Not specified
Topic:
Antioxidants, Toxicity, Biochemistry
Document Type:
Research Study
Institution:
Not specified
Author:
Not specified
Target Audience:
Researchers, Pharmacologists, Biochemists
Period of Action:
Not specified
Approval Date:
Not specified
Date of Modifications:
Not specified
Year:
2026
Region / City:
Not specified
Subject:
Toxicology
Document Type:
Medical summary
Institution / Organization:
Medical or educational source
Author:
Not specified
Target Audience:
Healthcare professionals and medical students
Period Covered:
Acute and chronic exposure scenarios
Date of Compilation:
2026
Symptoms Covered:
Gastrointestinal, hematologic, neurologic, reproductive, hepatic, cardiovascular, respiratory
Investigations Included:
Blood tests, X-rays, COHb measurement
Treatment Approaches:
Chelation therapy, supportive care, emergency measures
Chemical Agents Discussed:
Lead, Iron, Carbon Monoxide
Year:
2022
Region / city:
Netherlands
Topic:
Cancer treatment, Abiraterone, Prostate cancer
Document type:
Research study
Institution:
Ziekenhuis Gelderse Vallei, Radboudumc
Author:
Indy Murdoch, Emmy Boerrigter, Arnold Baars, Floor Lubberman
Target audience:
Healthcare professionals, Researchers
Period of validity:
N/A
Date of approval:
February 4, 2022
Date of changes:
N/A
Year:
2022
Region / City:
Saudi Arabia
Topic:
Autoimmune Diseases, Hydroxychloroquine Toxicity, Physician-Patient Communication
Document Type:
Scientific Article
Organization / Institution:
Not specified
Author:
Aldarwesh A, Almustanyir A, Alharthi M, Alhayan D
Target Audience:
Medical professionals, Researchers
Period of Action:
Not specified
Approval Date:
Not specified
Date of Modifications:
Not specified
Keywords:
Hydroxychloroquine, Autoimmune Diseases, Physician-Patient Communication, Toxicity
Note:
Contextual Description
Year:
2023
Region / City:
Québec, Canada; Pessac, France
Subject:
Ecotoxicology, Aquatic Toxicology
Document Type:
Research Article
Institution:
Institut National de la Recherche Scientifique – Centre Eau Terre Environnement; Univ. Bordeaux, CNRS, EPOC, EPHE
Authors:
Charlotte Bourdon, Jérôme Cachot, Patrice Gonzalez, Patrice Couture
Target Audience:
Researchers in ecotoxicology and environmental sciences
Study Species:
Oncorhynchus mykiss juveniles
Exposure Type:
Acute and chronic copper pyrithione exposure
Measured Parameters:
Mortality rates, growth, antioxidant enzyme activity, gene expression
Keywords:
Copper pyrithione, antifouling, copper sulphate, rainbow trout juveniles, lethal toxicity, sub-lethal toxicity, oxidative stress, gene expression
Abstract Focus:
Comparative toxicity of CuPT and CuSO4 on rainbow trout
Field:
Ecotoxicology
Document type:
Supporting information file
Content type:
Methodological appendix with model formulations and simulation data
Subject:
Estimation of no-effect toxicity concentrations (NEC) and ECx metrics
Models described:
NEC3param, NEC4param, ECxLinear, ECxExp, ECxSigmoidal, ECx4param, ECxWeibull1, ECxWeibull2
Software / framework:
jagsNEC (Bayesian modelling approach)
Key parameters:
τ (upper plateau / intercept), η (NEC), β (decay rate), δ (lower plateau), ω (EC50)
Methods included:
Threshold models, sigmoidal decay models, Weibull models
Data type:
Simulated toxicity and concentration–response data
Simulation design:
Multiple sampling schemes with varying treatment levels, replicates, and binomial trials
Measured variable:
Concentration–response relationships for toxicity effects
Chemical context:
Weathered Ichthys condensate WAF expressed as Total Aromatic Hydrocarbons (µg/L TAH)
Biological context:
Tropical marine species responses including A. millepora, S. variolaris, N. dorsatus, and A. amphitrite
Statistical approach:
Bayesian model fitting with MCMC and DIC-based model weighting
Included materials:
R functions for simulation data generation, model equations, simulation study tables, and figure of fitted concentration–response curves
Tables:
Model weight comparison (Table S1); toxicity estimates and effects across simulation designs (Table S2)
Figure:
Concentration–response relationships with Bayesian NEC-sigmoidal model fits (Figure S1)