№ lp_2_3_48136
File format: docx Character count: 7337 File size: 6513 KB
Supplemental research figures and tables presenting in vitro and in vivo experiments evaluating WSD0628 as a radiosensitizer, including kinase inhibition, DNA damage response, tumor growth, and survival outcomes in brain tumor models.
Year: 2026
Region / City: Rochester, Minnesota, USA; Jinan, Shandong, China; Minneapolis, Minnesota, USA; Corona, California, USA
Subject: Oncology, Radiobiology, Pharmacology
Document Type: Supplemental Data / Research Figures and Tables
Institution: Mayo Clinic; Cheeloo College of Medicine, Shandong University; University of Minnesota; Wayshine Biopharm Inc
Authors: Zhiyi Xue, Ann C. Mladek, Sneha Rathi, Sonia Jain, Rachael A. Vaubel, Lateef A. Odukoya, Darwin A. Garcia, Lily Liu, Katrina K. Bakken, Brett L. Carlson, Lauren L. Ott, Danielle M. Burgenske, Zeng Hu, Sonja Dragojevic, Paul A. Decker, Matthew L. Kosel, William G. Breen, Shiv K. Gupta, Jeanette E. Eckel-Passow, William F. Elmquist, Wei Zhong, Jann N. Sarkaria
Target Audience: Researchers in oncology and pharmacology
Experimental Models: U251, GBM43, GBM120, GBM12, M12eGFP-fLuc2 cell lines; mouse orthotopic xenografts
Treatment Interventions: WSD0628, radiation therapy, DDR inhibitors
Assays and Measurements: TR-FRET kinase assay, Western blotting, histological evaluation, survival analysis
Statistical Methods: Two-sample t-test, median and mean ± SD reporting
Period of Study: 2026
Price: 8 / 10 USD
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Generation and analysis of transgenic mice and patient-derived xenografts for Atoh1 studies
Year: 2026
Region / Institution: University of Oregon, Sanford Research, Institut Curie, Necker Hospital, Hospital for Sick Children
Field: Molecular biology / Neuro-oncology
Document type: Research supplemental materials and methods
Organ / Institution: Transgenic Mouse Facility, Sanford Research, Institut Curie, Necker Hospital
Authors: Not specified
Target audience: Researchers in genetics and oncology
Experimental models: Transgenic mice, ES cells, patient-derived xenografts (PDX)
Animal procedures approval: Sanford Research IACUC, Institut Curie ethical committee IDFParis-Comité 1 (#2011-0012)
Human research approval: Institutional Review Board at Necker Hospital, Research Ethics Board at the Hospital for Sick Children
Techniques used: DNA constructs, transgenic mouse generation, orthotopic transplantation, bioluminescence imaging, NanoString gene expression profiling, DNA methylation analysis
Drugs / treatments: Tamoxifen, vismodegib
Mouse strains: C57BL/6J, B6.Cg-Tg(Atoh1-cre)1Bfri/J, Tg(Atoh1-cre/Esr1*)14Fsh/J, B6N.129-Ptch1tm1Hahn/J, C57BL/6-Tg(Neurod2-Smo*A1)199Jols/J, NOD.Cg-Prkdc Il2rg/SzJ, athymic nude, Tg(Lmx1a-cre)1Kjmi
Cell lines: JM8.N4 ES cells
Topics: Radiosensitizing WSD0628 Xenografts