Year:
2006–2011
Region / city:
Penang, Malaysia
Subject:
Chromosomal abnormalities, cytogenetics
Document type:
Research article
Institution:
Advanced Medical and Dental Institute, Universiti Sains Malaysia; Institute for Medical Research, Kuala Lumpur
Authors:
Mot Yee Yik, Zubaidah Zakaria, Siti Fatimah Ramli, Nazlina Isa, Ruzziatul Ema, Abdul Rahman Azhari, Abdul Razak Abdul Khalid, Narazah Mohd Yusoff
Target audience:
Medical researchers, geneticists, clinicians
Sample source:
Peripheral blood lymphocytes from multiple hospitals in north-western Malaysia
Methods:
Karyotyping, G-banding, fluorescence in situ hybridization (FISH)
Results:
1461 cases analyzed, 1338 successful cultures, 397 cases with chromosomal abnormalities, Down syndrome most frequent, numerical abnormalities 84.38%
Comparative analysis:
Compared to previous regional and international studies
Key findings:
Increasing sample referrals, statistical differences in frequency of certain chromosomal abnormalities
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