№ files_lp_4_process_3_102067
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Policy document outlining the commissioning and clinical criteria for using glucarpidase in urgent cases of toxic plasma methotrexate concentrations due to delayed elimination in England.
Publication date:
March 2024
Version:
3.0
First published:
January 2015
Last updated:
December 2022
Region:
England
Type:
Clinical commissioning policy
Organization:
NHS England
Indication:
Toxic plasma methotrexate concentration due to delayed methotrexate elimination
Target population:
Adults and children receiving high-dose methotrexate chemotherapy
Therapeutic area:
Oncology / Haematology
Administration:
Urgent intravenous use
Expected annual use:
5–20 patients
Evidence base:
Phase II studies, case reports, pooled compassionate-use trials
Risk assessment:
Life-threatening methotrexate toxicity
Ethical framework:
NHS healthcare commissioning principles, Individual Funding Request guidance
Price: 8 / 10 USD
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The product description is provided for reference. Actual content and formatting may differ slightly.
Year:
2023
Region / city:
Australia
Theme:
Pharmaceutical submission
Document type:
Pharmaceutical submission
Organization / institution:
Pfizer Australia Pty Ltd
Author:
Not specified
Target audience:
Medical practitioners, nurse practitioners
Effective period:
Not specified
Approval date:
Not specified
Amendment date:
Not specified
Context:
Pharmaceutical submission requesting the inclusion of a new formulation of methotrexate under the General Schedule of the PBS for Australia, with changes in packaging and excipient composition.
Note:
Year
Theme:
Rheumatology, Methotrexate Therapy, Drug Interaction
Document Type:
Medical Guidelines
Target Audience:
Healthcare Professionals, Specialists
Version:
HNY v3.0
Replaces version:
HNY v2.0
Clinical content last reviewed:
November 2023
Next review date:
July 2028
Local approval:
1st October 2025
Target population:
Adults aged 18 and over, excluding cancer care
Indications:
Licensed and off-label use in rheumatoid arthritis, Crohn’s disease, psoriasis, psoriatic arthritis, and other chronic inflammatory conditions
Administration routes:
Oral, subcutaneous
Monitoring requirements:
Blood tests, infection screening, vaccination advice, renal function assessment, pregnancy considerations
Responsible organizations:
HNY ICB, RDTC
Document type:
Shared Care Protocol
Contextual description:
Clinical guidance source detailing licensed and off-label methotrexate indications, administration, monitoring, and transfer protocols between specialist and primary care for adults in non-cancer services.
Year:
2023
Region / city:
Australia
Topic:
Rheumatology, Pharmaceutical Listings
Document type:
Submission to Pharmaceutical Benefits Advisory Committee (PBAC)
Organization:
Link Medical Products Pty Ltd
Author:
Not specified
Target audience:
Healthcare professionals, PBAC members
Period of validity:
Not specified
Approval date:
Not specified
Date of changes:
Not specified
Note:
Context
Year:
2017-2018
Region / City:
Doncaster
Subject:
Healthcare
Document Type:
Service Specification
Organization:
NHS
Author:
Unknown
Target Audience:
Healthcare Providers (GPs, Specialists)
Period of Validity:
1st April 2017 to 31st March 2018
Approval Date:
Not specified
Date of Review:
Annual
Year:
2021
Region / city:
Ghent, Belgium
Theme:
COVID-19 impact on PhD trajectories
Document type:
Funding request
Institution:
Ghent University
Author:
Ghent University Research Administration
Target audience:
PhD students, promoters
Period of validity:
Until funding is granted
Approval date:
N/A
Date of amendments:
N/A
Year:
2026
Region / City:
Global
Document Type:
Research data / Supplementary table
Institution:
Not specified
Author:
Not specified
Target audience:
Medical professionals, researchers
Period of validity:
Not specified
Date of approval:
Not specified
Date of amendments:
Not specified
Note:
Contextual description
Note:
Year
Region / City:
Karnataka, India
Subject:
Dental Education and Professional Registration
Document Type:
Affidavit
Institution / Authority:
Karnataka State Dental Council
Author:
Individual Dental Graduate
Target Audience:
Regulatory Authority
Period Covered:
Duration of internship and registration delay
Declaration Reason:
Failure to register within the stipulated six-month period
Year:
2021
Region / City:
Burnley
Country:
United Kingdom
Subject:
Public sector financial audit and publication of accounts
Document Type:
Public notice
Institution:
Burnley Borough Council
External Auditor:
Grant Thornton UK LLP
Related Legislation:
The Accounts and Audit Regulations 2015; The Accounts and Audit (Amendment) Regulations 2021
Financial Year End:
31 March 2021
Expected Audit Completion:
January 2022
Committee Notified:
Audit and Standards Committee
Committee Notification Date:
23 September 2021
Reason for Delay:
Impact of Covid-19 and additional national assurance work related to pensions and asset valuations
Planned Publication:
As soon as reasonably practicable after completion of the audit
Year:
2019
Region / City:
England
Subject:
Cardiac rehabilitation, health outcomes, healthcare costs
Document Type:
Research Article
Organization / Institution:
Centre for Health Economics, University of York; Department of Health Sciences, University of York
Author:
Hinde, S.; Harrison, A. S.; Bojke, L.; Doherty, P. J.
Target Audience:
Healthcare professionals, policy makers, researchers
Period of Validity:
Not specified
Approval Date:
Not specified
Date of Changes:
Not specified
Keywords:
Cardiovascular disease, cardiac rehabilitation, NHS, health economics, patient health, healthcare services, timely treatment
Jurisdiction:
California, United States
Region / City:
Sacramento County, California
Topic:
Privacy regulation and enforcement timeline
Document type:
Legal alert
Organization:
ATP
Related legislation:
California Privacy Rights Act (CPRA); California Consumer Privacy Act (CCPA)
Court:
Superior Court for Sacramento County, California
Case context:
Lawsuit filed by the California Chamber of Commerce
Key authority cited:
Cal. Civ. Code § 1798.185
Regulatory body:
California Privacy Protection Agency
Original regulatory adoption date:
March 29, 2023
Original planned enforcement date:
July 1, 2023
Court-ordered enforcement date for adopted regulations:
March 29, 2024
Rule for future regulations:
Enforcement delayed until one year after adoption
Affected sector:
Testing organizations and California businesses