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Formal record of the appeal hearing considering challenges to NICE’s guidance on fenfluramine for managing seizures in Lennox–Gastaut syndrome, detailing participant statements, grounds of appeal, and procedural deliberations.
Year: 2024
Organization: National Institute for Health and Care Excellence (NICE)
Document type: Appeal hearing decision
Subject: Fenfluramine treatment for Lennox–Gastaut syndrome
Participants: UCB Pharma, Royal College of Physicians, Tuberous Sclerosis Association, NICE appraisal committee
Location: United Kingdom
Target audience: NHS, healthcare professionals, stakeholders involved in rare epilepsy treatment
Hearing date: 6 September 2024
Panel chair: Professor Jon Cohen
Legal adviser: Amy Smith, DAC Beachcroft LLP
Evaluation scope: Assessment of clinical and cost effectiveness for fenfluramine in patients aged 2 years and older
Price: 8 / 10 USD
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The National Clinical Audit of Seizures and Epilepsies in Children and Young People Specification
Year: 2026
Region / City: United Kingdom
Subject: Epilepsy Care, Healthcare Quality Improvement, Clinical Audits
Document Type: Clinical Audit Specification
Organ / Institution: Healthcare Quality Improvement Partnership (HQIP)
Author: Not specified
Target Audience: Healthcare providers, clinicians, policymakers, patients, and the public
Period of Effectiveness: Ongoing
Approval Date: Not specified
Date of Amendments: Not specified
Form C: Annual Statistics of Production, Manufacture, Consumption, Stocks and Seizures of Narcotic Drugs under the Single Convention on Narcotic Drugs of 1961 and the 1972 Protocol
Organization: International Narcotics Control Board
Related instrument: Single Convention on Narcotic Drugs of 1961
Note: Related instrument 1972 Protocol amending the Single Convention on Narcotic Drugs of 1961
Document type: Statistical reporting form
Scope: Production, manufacture, consumption, utilization, stocks and seizures of narcotic drugs
Addressee: Governments of countries or territories
Reporting deadline: Not later than 30 June of the year following the reporting year
Reporting period: Calendar year
Submission address: Vienna International Centre, P.O. Box 500, 1400 Vienna, Austria
Contact email: [email protected]
Website: http://www.incb.org/
Structure: Part I (Manufacture, consumption, utilization and stocks); Part II (Utilization for manufacture of other substances); Part III (Licit cultivation and production of plant-based narcotic materials); Part IV (Seizures of narcotic drugs and pharmaceutical products)
Measurement units: Kilograms and grams; for certain substances grams and milligrams
Reference document: List of Narcotic Drugs under International Control (“Yellow List”)
FORM CANNUAL STATISTICS OF PRODUCTION, MANUFACTURE, CONSUMPTION, STOCKS AND SEIZURES OF NARCOTIC DRUGS
Note: Year
High-Dose Methotrexate-Induced Seizures in a Relapsed B-ALL Patient and Management Outcomes
Year: 2026
Region / City: Not specified
Topic: Pediatric Hematology, Neurotoxicity
Document Type: Case Report
Institution: Not specified
Author: Not specified
Target Audience: Medical professionals
Patient Age: 6–14 years
Diagnosis: Relapsed B-cell Acute Lymphoblastic Leukemia (B-ALL)
Treatment Protocols: MRC-11, BFM 2002
Drug: High-Dose Methotrexate (HDMTX), Intrathecal Methotrexate (ITMTX), Levetiracetam, Diazepam
Clinical Events: Generalised tonic-clonic seizures, neurotoxicity
Outcome: Successful continuation of HDMTX and ITMTX without further seizures
Follow-up Duration: 2 years 3 months of anti-convulsant therapy
Imaging Findings: Normal brain MRI, hepatosplenomegaly on abdominal ultrasound
Laboratory Findings: Bone marrow immunophenotyping and cytogenetics detailed in report
Risk Stratification: Intermediate
FORM CANNUAL STATISTICS OF PRODUCTION, MANUFACTURE, CONSUMPTION, STOCKS AND SEIZURES OF NARCOTIC DRUGS
Note: Year
Subject: Narcotic Drugs
Document type: Form
Organization: International Narcotics Control Board
Author: International Narcotics Control Board
Target audience: Governments of countries and territories
Period of validity: Annually
Contextual description: A statistical form used to report data on the production, consumption, and seizures of narcotic drugs by governments.
Minnesota Handbook on Motor Vehicles: Stops, Warrantless Searches, Seizures (First Edition, August 2012)
Year: 2012
Edition: First Edition
Region / State: Minnesota, United States
Subject: Motor vehicle stops, warrantless searches, seizures, Fourth Amendment law
Document Type: Legal handbook / judicial training manual
Author: Hon. Alan F. Pendleton
Author Position: Tenth Judicial District Court Judge, State of Minnesota
Institutional Context: Tenth Judicial District Court, State of Minnesota
Research Assistants: Michelle Margoles; Ian Mitchell; Chelsey Abrahamson (University of Minnesota Externs)
Manuscript Review and Editing: Lisa M. Damhof; Abby M. Novak; Kevin Toskey; Abigail Wucherer
Publication Date: August 2012
Publisher / Issuing Authority: Hon. Alan F. Pendleton
Place of Publication: Anoka County Courthouse, Anoka, Minnesota, United States
Address: 325 East Main Street, Anoka, Minnesota 55303
Contact: Telephone (763) 422-7309; [email protected]
Legal Framework: Minnesota case law and United States federal case law
Primary Legal Topic: Exceptions to the Fourth Amendment warrant requirement in motor vehicle searches
Intended Audience: Judges, attorneys, law enforcement officers, criminal justice trainees
Associated Training Material: Judicial training video “Motor Vehicles: Stops, Warrantless Searches, Seizures”
Training Format: Instructional handbook used with video-based criminal justice training sessions
Estimated Training Duration: Approximately four to six hours
Content Structure: Chapters, sections, legal explanations, and hypothetical scenarios (vignettes) with numbered questions and answers
Copyright: All rights reserved by Hon. Alan F. Pendleton
Language: English
Association between tramadol use and seizures: A nationwide case-case-time-control study
Year: 2003–2015
Country: South Korea
Topic: Pharmacoepidemiology, Seizure risk
Document type: Research article
Institution: Sungkyunkwan University; Jeonbuk National University; Samsung Advanced Institute for Health Sciences & Technology
Authors: Sohee Park, Hyesung Lee, Ju Hwan Kim, Ha-Lim Jeon, Ju-Young Shin
Target audience: Medical researchers, clinicians
Study design: Case-case-time-control study
Population: Patients diagnosed with seizures and prescribed tramadol
Sample size: 2,523 incident cases
Data source: National Health Insurance Service–National Sample Cohort (NHIS-NSC)
Exposure: Tramadol use
Outcome: Incidence of seizures
Analysis: Adjusted odds ratio, dose-response
Key period: 1–30 days risk period, 61–90 and 91–120 days reference periods
Corresponding author: Ju-Young Shin, PhD
Email: [email protected]
Publication type: Peer-reviewed journal article
Topics: fenfluramine Lennox–Gastaut Seizures