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High-resolution research article analyzing sleep fragmentation and stage transitions in narcolepsy type 1 patients and their siblings using mini-epoch scoring and detailed statistical models.
Year: 2026
Region: Norway, Germany, Denmark
Field: Sleep medicine, neurology
Document type: Research article with supplementary materials
Institution: Oslo University Hospital, University of Oslo, University of Tübingen, Technical University of Denmark, WS Audiology, Novo Nordisk
Authors: Louise Frøstrup Follin, Rannveig Viste, Janita Vevelstad, Kristin Langdalen, Berit Hjelde Hansen, Ragnhild Kristine Berling Grande, Tobias Kaufmann, Julie Anja Engelhard Christensen, Alexander Neergaard Zahid, Marte Kathrine Viken, Hilde T. Juvodden, Stine Knudsen-Heier
Target audience: Clinicians and researchers in sleep disorders and neurodevelopmental conditions
Methods: Linear mixed-effects models, linear regression, 5-second and 30-second epoch sleep scoring, Markov analysis
Data included: Sleep fragmentation indices, stage transition probabilities, wake period analyses
Participants: NT1 patients (N=125) and their non-narcoleptic siblings (N=100)
Genetic and clinical variables: H1N1 vaccination status, CSF hcrt-1 levels, HLA-DQB1*06:02 positivity, presence of EDS, cataplexy, hypnagogic hallucinations, sleep paralysis
Night segmentation: Full-night and split-night analyses
End points: Transition indices, sleep-wake indices, NREM-REM transitions, statistical effect sizes and p-values
Supplementary material: Figures S1–S2, Tables S1–S5
Price: 8 / 10 USD
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