№ lp_2_3_61457
Research article describing a solid-phase synthetic strategy for incorporating 1,2-HOPO-4-COOH into lysine-containing peptides and evaluating coupling efficiency and deprotection conditions.
Document type: Scientific research article
Field: Peptide chemistry
Topic: Solid-phase peptide synthesis and chelator incorporation
Chemical compound: 1-Hydroxypyridine-2-one (1,2-HOPO)
Derivative studied: 1,2-HOPO-4-COOH
Methodology: Solid-Phase Peptide Synthesis (SPPS)
Resin: Rink-amide resin
Protecting group: Methyltrityl (Mtt)
Coupling reagent: N,N’-diisopropylcarbodiimide (DIC)
Additive: OxymaPure®
Cleavage reagent: Trifluoroacetic acid (TFA)
Additional reagent: Trifluoromethanesulfonic acid
Analytical method: HPLC
Subject of study: Incorporation of HOPO derivatives into Lys-containing peptides
Research focus: Comparison of masked and unmasked N-hydroxy group during coupling
Price: 8 / 10 USD
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