№ files_lp_4_process_3_092025
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Population PK/PD modeling source detailing secukinumab distribution, IL-17A binding, and associated pharmacokinetic parameters using a multi-compartmental PBPK-TE-MBMA framework.
Year: 2013
Model type: mPBPK-TE-MBMA
Drug: secukinumab
Based on: 2nd generation mPBPK-TE model for IL-17 (Cao & Jusko, JPKPD, 2013)
Author: JLee
Data file: IL17_mPBPK_NM_v01_LN.csv
Subroutines: ADVAN6
Compartment description: ABS, serum, muscle, leaky, skin, lymph, total IL17A serum, total IL17A skin
Parameters: CL, FA, KA, L, LS, L1, L2, VP, V1, V2, VS, VL, kdegSK, kdegSE, kintSK, kintSE, BSsk, BSse, KD, sSK, s1, s2, sL
Error model: combined additive and proportional, log-transform for serum and skin PK
Simulation: 1234 replicates, NSUBPROBLEMS=1, ONLYSIM
Output tables: sdtab1128, patab1128, catab1001, cotab1001
Target audience: pharmacometricians, modelers
Scope: pharmacokinetic and target engagement predictions for secukinumab in serum and skin compartments
Price: 8 / 10 USD
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Secukinumab: General Schedule Authority Required Listing for Moderate to Severe Hidradenitis Suppurativa Treatment
Year: 2023
Region / City: Australia
Topic: Hidradenitis Suppurativa Treatment
Document Type: Submission for Pharmaceutical Benefits Scheme (PBS) Listing
Organ / Institution: Novartis Pharmaceuticals Australia Pty Limited
Author: Novartis Pharmaceuticals Australia Pty Limited
Target Audience: Medical professionals, Healthcare policymakers
Period of Validity: Not specified
Approval Date: Not specified
Date of Amendments: Not specified
Category / Program: General Schedule (Code GE)
Prescriber Type: Dental Medical Practitioners, Nurse Practitioners, Optometrists, Midwives
Restriction Type: Authority Required
Severity: Moderate to severe
Condition: Hidradenitis suppurativa
Treatment Phase: Initial treatment
Clinical Criteria: Hurley stage II or III grading, abscess and inflammatory nodule count ≥ 3, failure to respond to antibiotics
Treatment Criteria: Dermatologist supervision
Population Criteria: Adult patients
Administrative Advice: Subcutaneous injection
Prescribing Instructions: Must assess disease severity, first 4 weeks under restriction
Cost: $6,145.10 for 300 mg/2 mL pre-filled syringe/pen
Source: Table 1.1, p25; Table 1.6, p35; Table 1.7, pp36-37; Table 1.7, p38
Il-17 Signaling in Primary Sclerosing Cholangitis Patient-Derived Organoids
Year: 2023
Region / City: N/A
Subject: Primary Sclerosing Cholangitis, IL-17 Signaling
Document Type: Research Article
Organization / Institution: Mayo Clinic
Author: Ana Sofia Garcia Moreno, Maria Eugenia Guicciardi, Alexander Q. Wixom, Erik Jessen, Jingchun Yang, Sumera I. Ilyas, Jackie K. Bianchi, Filippo Pinto e Vairo, Konstantinos N. Lazaridis, Gregory J. Gores
Target Audience: Researchers, Healthcare professionals, Scientific community
Period of Validity: N/A
Date of Approval: N/A
Date of Changes: N/A
Topics: mPBPK-TE-MBMA Secukinumab Il-17