№ files_lp_4_process_3_071335
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Supplementary scientific figures showing HER2 protein expression and chromatin accessibility differences between parental SKBR3 cells and lapatinib-resistant SKBR3-L cells, including microscopy images, quantitative fluorescence analysis, and genome-wide accessibility profiling.
Year: 2026
Region / city: Not specified
Subject: Molecular biology, cell signaling
Document type: Supplementary figure description
Institution: Not specified
Author: Not specified
Cell lines: SKBR3, SKBR3-L
Experimental techniques: Fluorescence microscopy, imageJ analysis, chromatin accessibility assay, MA plot analysis
Statistical analysis: Unpaired t-test with Welch’s correction, p < 0.0001, adjusted p < 0.05
Magnification: 20x
Scale bars: 50 μm
Data points: n = 79 for parental cells, n = 31 for lapatinib-resistant cells
Target protein: HER2
Genomic features: Transcription start sites (TSS), nucleosome positioning
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Template for Reporting Results of HER2 (ERBB2) Biomarker Testing of Specimens from Patients with Adenocarcinoma of the Stomach or Gastroesophageal Junction
Version: GastricHER2Biomarkers 1.0.0.1
Protocol Posting Date: June 2017
Year: 2017
Region / city: United States
Topic: HER2 biomarker testing, gastric cancer, gastroesophageal junction
Document type: Guideline
Organization / institution: College of American Pathologists, American Society for Clinical Pathology, American Society of Clinical Oncology
Author: Angela N. Bartley, MD; Jessi Christ, CTR; Patrick Fitzgibbons, MD; Stanley R. Hamilton, MD; Sanjay Kakar, MD; Manish A. Shah, MD; Laura H. Tang, MD, PhD; Megan L. Troxell MD, PhD
Target audience: Pathologists, oncologists, clinical laboratories
Period of validity: Indefinite
Date of approval: June 2017
Date of changes: N/A
Topics: SKBR3 SKBR3-L HER2