№ lp_2_3_22845
Technical occupational health guidance document establishing biological monitoring values, sampling procedures, analytical methods, and interpretation criteria for assessing workplace exposure to N,N-dimethylacetamide through urinary N-methylacetamide measurement.
Substance: N,N-Dimethylacetamide (DMA)
CAS number: 127-19-5
Monitored metabolite: N-methylacetamide (NMA) in urine
Biological Monitoring Guidance Value (BMGV): 100 mmol derived N-methylacetamide/mol creatinine
Conversion factor: 1 mmol/mol = 0.646 mg/g
Workplace Exposure Limits (8-hour TWA): 10 ppm, 36 mg/m3
Workplace Exposure Limits (15-minute STEL): 20 ppm, 72 mg/m3
Skin notation: Yes
Target audience: Employers and individuals responsible for managing workplace exposure
Half-life (skin exposure): 9–18 hours
Half-life (inhalation exposure): 5–9 hours
Sample type: Urine
Sampling time: End of shift; end of working week for consecutive exposures
Analytical technique: Gas chromatography with mass spectrometry detection
Detection limit: 6 µmol/L
Limit of quantitation: 10 µmol/L
Calibration range: 0–1300 µmol/L
Sample stability: 2 days at ambient temperature; >3 months frozen
Quality assurance scheme: GEQAS
Other guidance values: ACGIH BEI 30 mg/g; DFG BAT 25 mg/L (based on 5 ppm TWA)
Issuing body: Health and Safety Executive
Related organizations: American Conference of Governmental Industrial Hygienists; Deutsche Forschungsgemeinschaft; British Occupational Hygiene Society
Geographical scope: United Kingdom
Price: 8 / 10 USD
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