№ files_lp_4_process_2_73548
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Preclinical research article detailing the characterization, cytotoxicity, and target-specific activity of the TROP2-directed antibody–drug conjugate OBI-992 across various in vitro and in vivo cancer models.
Year: 2026
Type of document: Research article / Supplemental methods
Subject: Oncology, antibody–drug conjugates
Authors: Wan-Fen Li, Ming-Feng Chiang, Hao-Cheng Weng, Jhih-Jie Yang, Hsin-Shan Wu, Szu-Yu Wu, Yu-Jung Chen, Chi‐Huan Lu, Jyy-Shiuan Tu, Ren-Yu Hsu, Chi-Sheng Shia, Teng-Yi Huang, Ming-Tain Lai
Affiliation: Various research institutions (detailed in original publication)
Experimental models: Multiple human and murine cancer cell lines, PDX models
Key molecules studied: OBI-992, exatecan, Dato-DXd
Assays performed: Hydrophobic interaction chromatography, RPLC-UV, LC/MS/MS, flow cytometry, ELISA, ATP measurement, RNA-seq
Cell lines: NCI-N87, BxPC3, HCC827, NCI-H1975, MDA-MB-231, Capan-1, ES-2/GFP, MC38, HCC827/ABCB1, HCC827/ABCG2, Caco-2
Key outcomes measured: DAR distribution, IC50 values, TROP2 expression, immunogenic cell death markers, ABC transporter expression
Data sources: Crown Bioscience, WuXi Biologics, Human Protein Atlas
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