№ files_lp_3_process_7_053751
Clinical research study analyzing predictors of augmented renal clearance in critically ill pediatric patients in an academic PICU based on iohexol-measured glomerular filtration rate.
Authors: Evelyn Dhont; Tatjana Van Der Heggen; Evelien Snauwaert; Jef Willems; Siska Croubels; Joris Delanghe; Johan VandeWalle; Peter De Paepe; Pieter A. De Cock
Study design: Retrospective analysis of data from a prospective interventional study
Setting: Academic pediatric intensive care unit (PICU)
Population: Critically ill children with normal serum creatinine
Sample size: 85 patients
Median age: 16 months (IQR 5;89)
Clinical profile: 59% surgical patients
Topic: Augmented renal clearance and glomerular filtration rate assessment
Objective: Identification of predictors of augmented renal clearance
Methodology: Measurement of glomerular filtration rate by iohexol plasma clearance and multivariable logistic regression analysis
Definition of ARC: GFR exceeding normal age-adjusted values plus 2 standard deviations
Key findings: Postoperative status identified as independent predictor of ARC; lower odds of ARC after cardiac surgery
Statistical measures: Odds ratios with 95% confidence intervals and p-values
Drugs concerned: Hydrophilic drugs including antimicrobials and heparins
Price: 8 / 10 USD
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