№ files_lp_4_process_3_095599
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A collection of clinical trial tables summarizing interventions with SGLT2 inhibitors in acute and worsening heart failure, detailing patient criteria, treatment effects, and outcomes on decongestion and cardiovascular endpoints.
Year: 2020–2024
Study type: Randomized controlled trial
Drug class: SGLT2 inhibitors (Empagliflozin, Dapagliflozin, Sotagliflozin)
Patient population: Adults with acute heart failure or worsening heart failure, including those with type 2 diabetes
Sample size: 33–1,222 patients per study
Primary outcomes: Clinical endpoints, urine output, diuretic response, NT-proBNP changes, weight change, cardiovascular events
Secondary outcomes: Hemoconcentration, plasma osmolality, urinary sodium and glucose excretion, KCCQ-TSS, hospitalization rates
Treatment duration: 3 days–4 weeks
Geographic context: Multicenter international studies
Eligibility criteria: Age ≥18 years, signs of congestion, eGFR ≥15–30 mL/min/1.73 m² depending on study, stabilized hemodynamics
Safety outcomes: Renal function, electrolyte changes, body weight, adverse events
Price: 8 / 10 USD
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