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A detailed description of the experimental methodologies used to evaluate the cytotoxicity of CR-1-31B in osteosarcoma cell lines and drug synergy analysis.
Year: 2023
Region / City: N/A
Theme: Cytotoxicity assays, cancer research
Document Type: Research Methodology
Organization / Institution: N/A
Author: Vichai et al., Ianevski et al., Duivenvoorden et al.
Target Audience: Researchers in oncology and pharmacology
Period of Action: N/A
Date of Approval: N/A
Date of Changes: N/A
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Client Information Sheet: Call for cases: Dogs with osteosarcoma
Year: Not specified
Region / city: Not specified
Subject: Veterinary oncology, osteosarcoma in dogs
Document type: Research study invitation
Institution: Not specified
Author: Not specified
Target audience: Pet owners of dogs diagnosed with osteosarcoma
Period of validity: Not specified
Approval date: Not specified
Date of amendments: Not specified
Multidisciplinary Treatment of Bone Sarcomas: Osteosarcoma, Chondrosarcoma, and Ewing Sarcoma (2015–2025 Review)
Year of publication: 2025
Receipt of originals: 10/27/2025
Acceptance for publication: 11/27/2025
DOI: https://doi.org/10.56238/isevjhv4n6-002
Authors: Fernanda Cristina Galerani Gualtieri Parpinelli; Augustin Malzac; Henrique Lucas Codognoto; Cristina Jardelino de Lima; Guilherme Banck; Diogo Melo Mendo
Type of document: Narrative literature review
Field: Oncology; Orthopedic Oncology
Subject: Multidisciplinary management of osteosarcoma, chondrosarcoma, and Ewing sarcoma
Population focus: Pediatric and young patients with primary malignant bone tumors
Study period covered: 2015–2025
Databases consulted: PubMed; Scopus; Cochrane
Therapeutic approaches discussed: Surgical resection (R0 margins); Neoadjuvant and adjuvant chemotherapy (MAP; VAC/IE); Radiotherapy; Proton therapy; Immune checkpoint inhibitors; CAR-T cell therapy
Molecular aspects: EWS-FLI1 translocation; IDH1/IDH2 mutations; Circulating tumor DNA (ctDNA)
Imaging modalities: MRI; CT; PET-CT
Keywords: Osteosarcoma; Chondrosarcoma; Ewing Sarcoma; Targeted Therapy; EWS-FLI1; Biomarkers; Immunotherapy
Topics: Sulforhodamine CR-1-31B osteosarcoma