№ files_lp_4_process_1_40459
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Character count: 3454
File size: 1183 KB
The document provides a detailed list of protein interactions and restrictions used in the construction of a mutated BRCA1 model, focusing on specific activation and inhibition relationships among various genes and proteins.
Note:
Year
Topic:
Genetic Research
Document Type:
Supplementary Data
Target Audience:
Researchers, Geneticists
Price: 8 / 10 USD
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The product description is provided for reference. Actual content and formatting may differ slightly.
Year:
2024
Region / City:
N/A
Topic:
BRCA1 & BRCA2 variant classification
Document type:
Classification guidelines
Organization / Institution:
ACMG/AMP, ENIGMA
Author:
Variant Curation Expert Panel
Target audience:
Geneticists, researchers, healthcare professionals
Period of validity:
N/A
Approval date:
2024-11-18
Modification date:
N/A
Year:
2023
Region / City:
Global
Topic:
Variant Classification
Document Type:
Technical Specification
Organization / Institution:
ACMG/AMP, ENIGMA Variant Curation Expert Panel
Author:
Unknown
Target Audience:
Researchers, Geneticists, Clinicians
Period of Validity:
Ongoing
Approval Date:
2023-04-27
Date of Changes:
None
Study ID:
A211801
Study name:
BRCA-P
Document type:
Clinical trial eligibility criteria summary
Study type:
Randomized, double-blind, placebo-controlled clinical trial
Phase:
Phase 3
Geographic scope:
International multi-center study
Medical field:
Oncology
Target condition:
Breast cancer prevention in BRCA1 germline mutation carriers
Investigational drug:
Denosumab
Control:
Placebo
Population:
Women with confirmed deleterious or likely deleterious BRCA1 germline mutation aged 25–55 years
Key inclusion criteria:
No evidence of breast cancer by MRI or mammography and clinical breast examination within 6 months, no clinical evidence of ovarian cancer, ECOG performance status 0–1, written informed consent
Key exclusion criteria:
Prior bilateral mastectomy, history of breast or ovarian cancer, prior denosumab use, pregnancy or lactation, clinically relevant hypocalcaemia, certain prior hormonal or investigational treatments, significant medical or psychiatric conditions, active hepatitis B, hepatitis C, or HIV infection
Year:
20__
Region / City:
Ohio
Topic:
Land Use and Conservation Restrictions
Document Type:
Legal Declaration
Organization / Institution:
Ohio Public Works Commission
Author:
[Name of Declarant]
Target Audience:
Property owners and entities involved in land use and conservation grants
Effective Period:
Perpetual
Approval Date:
[Date of execution]
Amendment Date:
Not specified
Year:
2023
Region:
United Kingdom
Subject:
Nuclear Safety and Regulatory Compliance
Document Type:
Technical Inspection Guide
Organization:
Office for Nuclear Regulation (ONR)
Author:
Principal Inspector
Approved by:
Professional Lead – Nuclear Liabilities Regulation
Publication Date:
Feb-23
Next Review Date:
Feb-28
Document Reference:
NS-INSP-GD-004
Record Reference Number:
2023/7738
Revision Number:
4.2
Year:
2018
Region / City:
Uffington, Wootton Bassett, Swindon, London
Topic:
Dispute over Restrictions of Use imposed by Network Rail
Document Type:
Legal Dispute Reference
Organization / Institution:
DB Cargo (UK) Limited, Network Rail Infrastructure Limited
Author:
Not specified
Target Audience:
Parties involved in the dispute, legal professionals
Period of validity:
Not specified
Date of approval:
Not specified
Date of changes:
Not specified
Year:
2022
Region / City:
Knoxville, Tennessee
Subject:
Property Rights, Property Management
Document Type:
Legal Declaration
Author:
Kevin C. Stevens, Esquire
Target Audience:
Homeowners, Property Owners, Real Estate Associations
Effective Period:
From the date of approval
Approval Date:
2022
Date of Amendments:
2022
Note:
Year
Region / City:
Global
Subject:
Export Restrictions
Document Type:
Regulatory Compliance
Organization:
Pax8
Target Audience:
Business Partners, Resellers
Geographical Scope:
Global
Document type:
Government form
Form reference:
DEFFORM 711
Issuing body:
Ministry of Defence
Jurisdiction:
United Kingdom
Subject:
Intellectual Property Rights restrictions
Related processes:
Defence procurement and contracting
Structure:
Part A Notification of IPR Restrictions; Part B System/Product Breakdown Structure
Standards referenced:
ISO 21511; DEFSTAN 05-057
Intended users:
Contractors and suppliers to the Ministry of Defence
Associated documents:
Invitation to Tender; Contract documentation
Funding categories:
Private Venture Funded; Previous Authority Funded; Contract Authority Funded; Design Not Mature
Export control designation:
Foreign Export Controlled
Year:
2019
Region / City:
Summit County, Park City, Utah
Theme:
Affordable Housing, Condominium Development
Document Type:
Legal Agreement
Organization / Institution:
Summit County, Mountainlands Community Land Trust
Author:
Summit County, Mountainlands Community Land Trust
Target Audience:
Developers, Housing Authorities, Legal Professionals
Period of Validity:
Perpetual
Date of Approval:
May 14, 2019
Date of Amendments:
Not specified
Year:
20__
Region / City:
Maryland
Subject:
Dam Safety, Waterway Construction, Environmental Regulation
Document Type:
Legal Agreement
Organization / Institution:
Maryland Department of the Environment
Author:
Maryland Department of the Environment
Target Audience:
Property owners, legal representatives, and entities involved in dam or reservoir construction
Validity Period:
As per permit issuance or renewal
Approval Date:
________
Date of Changes:
As per amendments to permit terms
Note:
Year
Topic:
Technical Data, Computer Software
Document Type:
Contract, Supplier Assertion
Target audience:
Government, Suppliers
Contextual description:
A document related to the assertion of restrictions on technical data or computer software being delivered under a government contract, detailing the basis for asserting those restrictions and identifying the rights categories.
Year:
1997
Region / City:
Georgetown County, South Carolina
Theme:
Property law, real estate restrictions
Document Type:
Legal amendment
Organization / Institution:
Centex Homes
Author:
Centex Homes
Target Audience:
Property owners, real estate professionals, legal practitioners
Effective Period:
Indefinite
Approval Date:
05 December 1997
Modification Date:
None
Year:
2001
Region / City:
Riley County, Kansas
Topic:
Property Restrictions
Document Type:
Legal Agreement
Organization / Institution:
University Park Improvement District
Author:
Board of Directors
Target Audience:
Property Owners, Legal Professionals
Period of Validity:
Ongoing
Approval Date:
June, 2001
Date of Last Amendment:
November 30, 1995
Contextual Description:
Legal document outlining amended property restrictions for University Park Improvement District in Riley County, Kansas.
Year:
2023
Region / city:
Geneva
Topic:
Emerging technologies, lethal autonomous weapon systems
Document type:
Final report
Organization / institution:
Convention on Prohibitions or Restrictions on the Use of Certain Conventional Weapons
Author:
High Contracting Parties to the Convention
Target audience:
Governments, international organizations
Period of validity:
2023
Approval date:
15 November 2023
Date of amendments:
N/A
Context:
Report on the work and decisions of the High Contracting Parties to the CCW regarding lethal autonomous weapon systems and the continuation of relevant discussions and activities.
Year:
2021
Region / City:
Geneva
Topic:
Lethal Autonomous Weapons Systems, Emerging Technologies
Document Type:
Report
Organization / Institution:
Group of Governmental Experts on Emerging Technologies in the Area of Lethal Autonomous Weapons Systems
Author:
N/A
Target Audience:
High Contracting Parties, Experts on Emerging Technologies
Period of Validity:
2021
Date of Adoption:
22 February 2022
Date of Changes:
N/A
Date:
9 August 2021
Country:
Scotland
Topic:
Sighted guiding and COVID-19 safety
Document type:
Guidance
Issuing organisations:
RNIB; Guide Dogs; Thomas Pocklington Trust
Related authorities:
Scottish Government
Target audience:
Blind and partially sighted people; sighted guiders; staff and volunteers
Public health context:
Coronavirus (COVID-19)
Validity period:
From 9 August 2021
Contact email:
[email protected]
Contact telephone:
0303 123 9999