№ lp_2_3_60720
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File size: 63 KB
Supplemental scientific material presenting patient enrollment flowcharts and statistical performance tables evaluating an artificial intelligence hemorrhage risk algorithm across trauma cohorts stratified by injury type and gender.
Authors:
Jonathan D. Stallings; Srinivas Laxminarayan; Chenggang Yu; Adam Kapela; Andrew Frock; Andrew P. Cap; Andrew T. Reisner; Jaques Reifman
Affiliations:
United States Army Institute of Surgical Research; Department of Defense Biotechnology High Performance Computing Software Applications Institute; Telemedicine and Advanced Technology Research Center; United States Army Medical Research and Development Command; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.; Massachusetts General Hospital
Institutions involved:
Memorial Hermann Life Flight (MHLF); Boston MedFlight (BMF); Massachusetts General Hospital (MGH)
Subject:
Artificial intelligence in trauma triage and hemorrhage risk assessment
Document type:
Supplemental digital content with flowcharts and statistical tables
Population:
Adult trauma patients aged 18–90 years
Total patients analyzed:
1,659 trauma patients (blunt and penetrating injuries)
Key variables:
Hemorrhage Risk Index (HRI); hemorrhage risk; likelihood ratio; PRBC transfusion within 24 hours
Injury types analyzed:
Blunt injury; Penetrating injury
Stratification variables:
Mode of injury; Gender
Statistical measures:
95% confidence intervals
Data sources:
MHLF; BMF; MGH trauma cohorts
Content elements:
Patient enrollment flowcharts; performance tables (S1–S4)
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Year:
2023–2025
Region / City:
South Africa, Democratic Republic of the Congo
Topic:
Military deployment, personnel health
Document type:
Parliamentary written reply
Institution:
Ministry of Defence and Military Veterans, National Council of Provinces
Author:
Minister of Defence and Military Veterans
Intended audience:
Members of Parliament, public officials
Date of publication:
07 March 2025
Reported by:
Chief of the South African National Defence Force
Number of troops deployed:
174
Number of injured personnel:
152
Number of pregnant personnel:
2
Return dates of injured personnel:
February 2024–February 2025
Nature of injuries:
shrapnel wounds, bullet wounds
Year:
2020
Region / City:
College Park, Maryland
Topic:
Hemorrhage Control, Medical Testing
Document Type:
Report
Institution:
Medcura, Inc
Author:
Medcura, Inc
Target Audience:
Researchers, Medical Professionals
Period of Validity:
N/A
Approval Date:
N/A
Date of Changes:
N/A
Note:
Description
Year:
2012
Authors:
Galina Lipton, MD; Maria F. McMahon MS, RN, cPNP-AC; Anne Stack, MD
Reviewed by:
Herminia Shermont, MS, RN, CNA, BC
Approved by:
David P. Mooney, MD, MPH; Steven Sloan, MD
Type of Document:
Clinical protocol
Target Audience:
Medical staff in emergency and trauma care
Scope:
Patients requiring rapid high-volume blood transfusion due to massive hemorrhage
References:
Technical Manual, 18th ed. American Association of Blood Banks, 2014; Holcomb JB et al., JAMA 2015, 313(5):471-82
Date of Origin:
09/01/2012
Year:
2017
Region / city:
Global
Theme:
Medical Research
Document type:
Research Article
Organization:
Not specified
Author:
Not specified
Target audience:
Medical professionals, researchers
Period of validity:
Not specified
Date of approval:
Not specified
Date of changes:
Not specified
Contextual description:
Systematic literature review on the global incidence of intraventricular hemorrhage among extremely preterm infants based on MEDLINE and Embase search strategies.
Year:
Not specified
Time of Admission:
20:22
Setting:
Emergency Department and Neurological Intensive Care Unit
Region:
Not specified
Type of Document:
Clinical case study
Subject:
Acute intracerebral hemorrhage with cerebral edema
Patient Demographics:
30-year-old Asian female
Chief Complaint:
Severe headache, left-sided weakness, dizziness, nausea
Relevant Medical History:
No significant past medical history
Family History:
Maternal history of migraine; maternal grandfather with stroke at age 69
Current Medications:
Estrostep Fe, multivitamin
Allergies:
No known drug allergies (NKDA)
Initial Neurological Status:
Glasgow Coma Scale 15 with dense left hemiparesis
Vital Signs on Admission:
BP 156/88, HR 90, RR 22, Temp 36.5℃
Diagnostic Imaging:
Non-contrast CT head
Imaging Findings:
Acute right frontal lobe hemorrhage with vasogenic edema and right-to-left midline shift
Laboratory Findings:
CBC, chemistry panel, coagulation profile within normal limits; negative urine toxicology
Interventions:
Intubation, propofol infusion, rocuronium, intravenous mannitol
Disposition:
Transfer to Neurological Intensive Care Unit
Complications Noted:
Increasing lethargy, bradycardia, elevated intracranial pressure
Planned Management:
Neuro checks every 15 minutes, repeat imaging, possible surgical intervention
Year:
2020–2022
Region / City:
Brussels, Belgium
Topic:
Obstetric anesthesia and peripartum hemorrhage
Document type:
Retrospective cohort study
Institution:
CHU Brugmann, Université Libre de Bruxelles (ULB)
Authors:
Levecq P., Lenoir N., Bidgoli SJ.
Target audience:
Obstetricians, anesthesiologists, medical researchers
Ethics approval:
CE 2024/115
Sample size:
1216 caesarean deliveries analyzed
Methods:
Comparison of general and neuraxial anesthesia on blood loss
References:
Van Stralen G. et al., 2016; Betrán AP. et al., 2016; Jee Y. et al., 2022
Funding:
None
Study guidelines:
STROBE
Observational period:
January 2020 – December 2022
Blood loss outcome:
Mean blood loss higher with general anesthesia than neuraxial anesthesia
Year:
2026
Region / city:
Not specified
Subject:
Neurology, Cognitive Neuroscience
Document type:
Supplementary Materials
Institution / Organization:
Not specified
Authors:
Not specified
Target audience:
Researchers and clinicians in neurology and neuroimaging
Study period:
Acute to 6 months post-aSAH
Methods:
MRI (sMRI, DTI, rs-fMRI), EEG, ERP, biomarker analysis
Patient groups:
aSAH patients, UIA controls
Biomarkers:
Amyloid β (Aβ40, Aβ42), tau protein, p-tau181, neurofilament light chain
Data presentation:
Tables (S1–S4), Figures (S1–S2)
Analytical focus:
Structural and functional brain changes, cognitive impairment, early diagnosis markers
Year:
2023
Region / City:
N/A
Topic:
Neuroimaging, Neurodevelopmental Outcomes, Preterm Infants
Document Type:
Research Article
Institution:
N/A
Author:
N/A
Target Audience:
Researchers, Pediatric Neurologists, Neonatologists
Period of Validity:
N/A
Date of Approval:
N/A
Date of Modifications:
N/A
Year:
2015
Region / City:
Jakarta, Indonesia; London, England; San Luis Obispo, California, USA
Subject:
Obstetrics, Postpartum Hemorrhage
Document Type:
Clinical Study
Author:
Yuditiya Purwosunu, MD; Widyastuti Sarkoen, MD; Sabaratnam Arulkumaran, MD, PhD; Jan Segnitz, MD
Funding:
InPress Technologies Inc.
Ethics Approval:
Faculty of Medicine, University of Indonesia, July 7, 2014
Presentation:
Asian and Oceanic Congress of Obstetrics and Gynaecology (AOCOG), June 3–6, 2015
Method:
Prospective proof-of-concept study on 10 women with vaginal deliveries
Device:
Vacuum-induced uterine tamponade device with occlusion balloon
Outcome:
Successful control of atonic postpartum hemorrhage in all cases
Target Population:
Women experiencing postpartum hemorrhage unresponsive to first-line therapies
Year:
Not specified
Document type:
Supplementary material
Content type:
Literature database search strategy
Research field:
Medicine
Academic field:
Neurology
Topic:
Subarachnoid Hemorrhage and Statin Therapy
Databases covered:
PubMed; Web of Science; Embase
Search components:
Controlled vocabulary terms; Title/Abstract keywords; Boolean operators
Key medical concepts:
Subarachnoid Hemorrhage; Aneurysmal Subarachnoid Hemorrhage; Statins; Hydroxymethylglutaryl-CoA Reductase Inhibitors
Structure:
Sectioned database queries with numbered search expressions
Purpose:
Identification of scientific literature related to subarachnoid hemorrhage and statin use
Source context:
Supplementary table associated with a biomedical research study