№ files_lp_4_process_3_092014
Supplementary scientific material presenting eligibility criteria, patient characteristics, and biomarker analyses from a placebo-controlled clinical trial examining osteo-immunological effects of radon and thermal spa treatment in patients with chronic degenerative spinal and joint conditions.
Study title: Osteo-immunological impact of radon spa treatment: Due to radon or spa alone? Results from the prospective, thermal bath placebo-controlled RAD-ON02 trial
Type of document: Scientific study supplement
Scientific field: Radiobiology; Osteoimmunology; Medical research
Authors: Denise Eckert; Megi Evic; Jasmin Schang; Maike Isbruch; Melissa Er; Lea Dörrschuck; Felicitas Rapp; Anna-Jasmina Donaubauer; Udo S. Gaipl; Benjamin Frey; Claudia Fournier
Corresponding author: Prof. Dr. Claudia Fournier
Institution: Department of Biophysics, GSI Helmholtzzentrum für Schwerionenforschung
Additional institution: Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU)
Country: Germany
Study name: RAD-ON02 trial
Study design: Prospective thermal bath placebo-controlled clinical trial
Population: Adult patients aged 18–75 with chronic degenerative spinal and joint complaints
Sample size: 58 patients
Patient groups: Group 1 (29 patients); Group 2 (29 patients)
Patient characteristics: Age, gender distribution, body mass index categories, and clinical indications
Inclusion criteria: Adult patients with chronic degenerative spinal or joint pain lasting at least one year and VAS pain intensity ≥4 with informed consent and availability for follow-up
Exclusion criteria: Pregnancy or breastfeeding, uncontrolled hypertension, severe heart failure, active inflammatory disease, recent radon therapy, substance abuse, or concurrent clinical trial participation
Analyzed biomarkers: MMP3; MMP9; Leptin; Visfatin; RANKL/OPG ratio
Statistical method: Kruskal-Wallis test
Figures and tables: Table S1; Table S2; Figures S1–S3
Price: 8 / 10 USD
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