№ files_lp_3_process_7_091283
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Supplementary scientific documentation detailing neuroimaging preprocessing, gene expression integration, partial least squares regression analyses, and validation procedures examining associations between cortical thickness variation and transcriptional profiles in children with autism and ADHD.
Authors: Romero-Garcia, R.; Warrier, V.; Bullmore, E.T.; Baron-Cohen, S.; Bethlehem, R.A.I.
Type of document: Supplementary scientific note
Field: Neuroimaging and transcriptomics
Research focus: Cortical thickness differences in autism and ADHD
Data sources: ABIDE; ADHD-200; Allen Institute for Brain Science gene expression dataset
Study population: Male children aged 8–12 years
Discovery sample size: 218 subjects
Validation datasets: ABIDE II (Georgetown University; Kennedy Krieger Institute)
Gene expression source: Post-mortem adult human brain samples (n=6 donors)
Methods: Structural MRI (T1-weighted MPRAGE); Freesurfer v5.3 processing; Partial Least Squares Regression; pathway and enrichment analyses
Brain parcellation: 308 cortical regions based on Desikan-Killiany atlas
Comparative groups: Autism; ADHD; neurotypical controls
Statistical procedures: Cross-validation; regression analyses; batch correction using ComBat
Associated analyses: KEGG pathway analysis; gene co-expression modules; rare and common genetic variant enrichment
References included: Yes
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Supplementary Table 2: Top 30 Upregulated and 30 Downregulated Genes in Treatment Group versus Untreated
Type of document: Supplementary table
Scientific field: Molecular biology
Research area: Gene expression analysis
Data type: Differential gene expression results
Comparison groups: Losartan+FFX+CRT versus untreated; FFX+CRT versus untreated
Measured variable: log2FoldChange
Number of upregulated genes listed: 30 per comparison
Number of downregulated genes listed: 30 per comparison
Biological entities: Human genes
Content structure: Gene names with corresponding log2FoldChange values
Context of study: Treatment-associated transcriptional changes
Preoperative Psoas Muscle Thickness to Height Ratio Predicts Survival After Resection of Biliary Tract Cancer
Year: 2010–2022
Region / City: Hyogo, Japan
Subject: Biliary Tract Cancer, Sarcopenia, Surgical Outcomes
Document Type: Clinical Study
Institution: Meiwa Hospital, Department of Surgery
Authors: Shinichi Ikuta, Tsukasa Aihara, Takayoshi Nakajima, Meidai Kasai, Naoki Yamanaka
Target Audience: Oncologists, Surgeons, Clinical Researchers
Patient Cohort: 211 patients undergoing BTC resection
Primary Tumor Sites: Intrahepatic bile duct, Extrahepatic bile duct, Gallbladder, Ampulla of Vater
Follow-up Method: Disease-specific survival (DSS), Relapse-free survival (RFS)
Ethics Approval: Institutional Ethics Committee of Meiwa Hospital, approval No. 2022-36
Design & Analysis of Pressure Vessel due to Change of Shell Thickness
Author: Sagar Uttamrao Bankar
Co-Author: Dr. Chetan Choudhary
Department: Mechanical Department
Institution: Sandip University, School of Engineering & Technology
Location: Nashik, India
Document Type: Academic Research Paper
Subject: Pressure Vessel Design and Structural Analysis
Keywords: Pressure vessel design & analysis, CATIA V5 R24, ANSYS Workbench, Welding
Standards Referenced: ASME Section VIII Division 2
Reference Manual: Pressure Vessel Design Manual, Third Edition, Dennis Moss
Software Used: ANSYS Workbench, CATIA V5 R24
Analysis Type: Finite Element Analysis (Static, Thermal, Dynamic)
Focus: Effect of Shell Thickness and Nozzle Configuration on Stress Distribution
Application Field: Mechanical Engineering, Chemical and Food Industry Equipment
Topics: Transcriptionally Downregulated Thickness