№ files_lp_4_process_2_47033
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Experimental study describing the distribution and structural integrity of porphysome nanoparticles in mice and rabbits with orthotopic lung tumors, including their accumulation in tissues, imaging, and photothermal ablation efficiency.
Year: 2021
Institution: University Health Network, Toronto
Animal models: Rabbits, Nude mice
Tumor models: A549, H520, H460, VX2
Methods: Biodistribution analysis, ex vivo fluorescence imaging, confocal microscopy, phantom fluorescence testing, transpleural ablation
Dosage: 20 mg/kg porphysomes
Injection route: Intravenous (tail vein)
Observation times: 24 h, 48 h post-injection
Tissue analysis: Lung with tumors, esophagus, heart, kidney, spleen, small intestine, large intestine, hind limb muscle
Measurement techniques: Spectrofluorimetry, microscopy, NADH enzyme-activity staining
Ablation parameters: Straight-cut fiber, 500 mW, 10 min irradiation
Price: 8 / 10 USD
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Topics: Porphysome Orthotopic Biodistribution