№ files_lp_4_process_3_107586
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Observational study data summarizing clinical, demographic, histological, and immunological characteristics of a cohort of esophageal small cell carcinoma patients.
Year of diagnosis:
Prior to 2015–2019
Number of patients:
147
Sex distribution:
109 male, 38 female
Age distribution:
≤60 years: 73, >60 years: 74
Alcohol abuse:
Yes: 71, No: 76
Tobacco abuse:
Yes: 97, No: 50
Smoking index:
≤400: 93, >400: 54
BMI distribution:
<25: 108, 25–29.9: 39
Family history of cancer:
Yes: 32, No: 115
Treatment modality:
Surgery alone: 48, Surgery with adjuvant therapy: 99
Tumor location:
Upper: 17, Middle: 111, Lower: 19
Tumor length:
<5 cm: 89, ≥5 cm: 58
Macroscopic tumor type:
Superficial: 22, Protruded: 11, Medullary: 48, Mushroom: 36, Ulcerative: 19, Intracavity: 11
Histological components:
Pure small cell: 116, Mixed small cell: 31
T stage:
T1: 45, T2: 39, T3: 59, T4: 4
N stage:
N0: 50, N1: 53, N2: 32, N3: 12
TNM stage:
I: 29, II: 49, III: 69
PD-L1 expression in tumor cells (TCs):
<1%: 147, ≥1%: 0
PD-L1 expression in tumor-infiltrating immune cells (TIICs):
<1%: 82, ≥1%: 65
PD-L1 expression by CPS:
<1: 105, ≥1: 42
CD8 density/mm²:
Median 111.1, Range 7.5–1458.6
Abbreviations:
BMI: body mass index; TCs: tumor cells; TIICs: tumor-infiltrating immune cells; CPS: combined positive score
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Version:
4.2.0.1
Protocol Posting Date:
June 2022
CAP Laboratory Accreditation Program Protocol Required Use Date:
March 2022
For accreditation purposes:
Surgical resection, including esophagectomy and esophagogastrectomy; Epithelial tumors of the esophagus, and esophagogastric junction with tumor involvement of no more than 2 cm into the proximal stomach.
Authors:
Lawrence J. Burgart, MD; William V. Chopp, MD; Dhanpat Jain, MD
Synoptic Reporting:
Core and conditional data elements must be reported in a synoptic format for accreditation.
Case Summary:
Esophagus
Histologic Type:
Adenocarcinoma, Squamous cell carcinoma, Neuroendocrine carcinoma, among others.
Year:
2021
Region / City:
Delhi, India
Subject:
Medical Research, Gastroenterology
Document Type:
Research Article
Organization / Institution:
Atal Bihari Vajpayee Institute of Medical Sciences and Dr. Ram Manohar Lohia Hospital, Postgraduate Institute of Medical Education and Research
Authors:
Gupta N, Yelamanchi R, Agrawal H, Agarwal N
Target Audience:
Medical Researchers, Endoscopists, Healthcare Professionals
Period of Validity:
N/A
Approval Date:
May 9, 2021
Date of Revisions:
May 20, 2021
Acceptance Date:
July 19, 2021
Publication Date:
August 28, 2021
Year:
2025
Region / City:
Not specified
Topic:
Medical procedures, Excluded services
Document Type:
Guideline
Author:
Not specified
Target Audience:
Healthcare providers, medical practitioners
Effective Period:
From 1/1/2025
Approval Date:
Not specified
Revision Date:
Not specified
Context:
This document provides an update on the status of capsule endoscopy for gastrointestinal tract imaging under Excluded Services Guidelines, highlighting its exclusion due to limited evidence of effectiveness and the existence of cost-effective alternatives.
Year:
2024
Country:
Canada
Study Type:
Phase II clinical trial
Treatment Regimen:
Bendamustine-Rituximab combination with concurrent Acalabrutinib
Participants:
62
Centers:
9
Primary Endpoint:
Combined Complete and Very Good Partial Response (CR+VGPR) rates
Secondary Endpoints:
Best overall response (BoR), progression-free survival (PFS), overall survival (OS), duration of response (DoR), Minimal Residual Disease (MRD)
Median Age:
69
Mutation Analysis:
MYD88 89.3%, CXCR4 28.6%, TP53 1.8%
Adverse Events:
Treatment-related adverse events (TRAEs) in 53 participants, 42 Grade 3/4 during combination therapy, 15 Grade 3/4 during monotherapy
Follow-up:
Median 350 days
Data Cut-off:
June 5, 2024
Document Type:
Clinical trial report
Year:
2023
Region / city:
Australia
Topic:
Oncology, Pharmaceuticals
Document Type:
Resubmission
Institution:
Australian Government, Pharmaceutical Benefits Advisory Committee
Author:
AstraZeneca Pty Ltd.
Target Audience:
Healthcare professionals, regulatory bodies
Effective Period:
Ongoing
Approval Date:
November 2021
Date of Changes:
November 2021
Year:
2025
Organization:
NICE Technology Appraisal Committee
Document type:
Interests Register
Region:
United Kingdom
Subject:
Conflicts of interest in health technology appraisal
Participants:
Peter Wheatley Price, Warren Linley, David McAllister, Professor Suneil Jain, Rhiannon Owen, Holly Knight
Date of publication:
TBC
Relevant period:
2025
Financial interests:
Pfizer, AstraZeneca, Bayer, Astellas, Johnson & Johnson, Boston Scientific, Teleflex, Accord, Molli Surgical, BXT Nanotherapy
Professional roles:
Committee members, clinical expert, patient expert
Access to trial data:
Yes
Appraisal ID:
4004
Record type:
Committee disclosures
Type of document:
Supplementary table
Scientific field:
Molecular biology
Research area:
Gene expression analysis
Data type:
Differential gene expression results
Comparison groups:
Losartan+FFX+CRT versus untreated; FFX+CRT versus untreated
Measured variable:
log2FoldChange
Number of upregulated genes listed:
30 per comparison
Number of downregulated genes listed:
30 per comparison
Biological entities:
Human genes
Content structure:
Gene names with corresponding log2FoldChange values
Context of study:
Treatment-associated transcriptional changes
Year:
2023
Region / city:
European Union
Theme:
Aviation, Maintenance, Training
Document type:
User Guide
Organisation:
European Aviation Safety Agency (EASA)
Author:
Omar Elkhartoufi
Target audience:
Applicants and approval holders of EASA Part 147 organisations outside the EU
Period of validity:
Not specified
Approval date:
15/11/2023
Date of changes:
15/11/2023
Year:
2024
Region / City:
West Virginia
Subject:
Concealed deadly weapons licenses
Document Type:
Legislative Act
Authority / Institution:
West Virginia Legislature
Author:
Senators Rucker, Deeds, Hamilton, Hunt, Oliverio, Phillips, Roberts, Swope, Tarr, Woodrum, Chapman, Jeffries
Target Audience:
Residents of West Virginia and other states wishing to apply for a concealed deadly weapon license
Period of Effectiveness:
90 days from passage
Approval Date:
March 8, 2024
Date of Changes:
Not specified
Year:
2016
Region / City:
Malaysia
Topic:
Maintenance Training Programme
Document Type:
Checklist
Organization:
Civil Aviation Authority of Malaysia
Author:
Not specified
Target Audience:
Maintenance Training Organizations
Validity Period:
Not specified
Approval Date:
Not specified
Date of Changes:
Not specified
Year:
2023
Region / city:
South Africa
Subject:
Information Technology - Systems Support
Document type:
Practical Assessment Form
Institution:
South African Qualifications Authority (SAQA)
Author:
N/A
Target audience:
Learners pursuing IT certifications
Validity period:
N/A
Approval date:
N/A
Modification date:
N/A
This document is a practical evaluation for learners pursuing a National Certificate in Information Technology:
Systems Support, assessing their ability to install, configure, and document a multi-user networked operating system according to specified standards and guidelines.
Year:
2023
Region / City:
Europe
Topic:
Aviation Training
Document Type:
User Guide
Author:
Omar Elkhartoufi
Target Audience:
Maintenance Training Organizations, Aviation Instructors
Effective Period:
N/A
Approval Date:
15/11/2023
Date of Revision:
15/11/2023
Year:
1980
Region / City:
United Kingdom, Buckinghamshire
Document Type:
Application form
Governing Body:
Buckinghamshire Council
Author:
Landowner, lessee, or occupier of agricultural land
Target Audience:
Applicants seeking to install a structure on a public footpath or bridleway
Legislation:
Highways Act 1980, Section 147; Disability Discrimination Act 2005
Structure Standards:
BS5709:2006 (Gaps, Gates and Stiles)
Submission Requirements:
Ordnance Survey Grid Reference, detailed specification of structure, fencing plan
Responsibilities:
Installation, notification to council, maintenance, compliance with conditions
Inspection:
Conducted by Rights of Way & Access Group, Buckinghamshire Council
Type of Source:
Official administrative application form
Note:
Structured guidance notes included for applicants regarding authorisation criteria, access considerations, and installation procedures
Official address for submission:
Rights of Way & Access Group, Buckinghamshire Council, Walton Street, Aylesbury HP20 1UY
Administrative processing:
Typically 4-week period for application review and approval
Chapter:
14.7
Subject:
Infection with Peste des Petits Ruminants Virus (PPRV)
Animal hosts:
Domestic sheep and goats
Other susceptible species:
Cattle, bovines, camelids, camels, buffaloes and certain wild ruminants
Incubation period:
21 days
Commodities addressed:
Meat products, milk and derivatives, gelatine, collagen, hides and skins, tallow, protein meal, extruded dry pet food
Type of document:
International veterinary standards
Issuing body:
World Organisation for Animal Health (WOAH)
Regulatory framework:
Terrestrial Code
Related documents:
Terrestrial Manual; Chapters 1.1, 1.4.6, 1.6, 2.1, 4.2, 4.3, 4.4, 4.5
Scope:
Conditions for disease definition, safe commodities, recognition of free status, compartmentalisation and containment zoning
Geographical scope:
Member Countries of WOAH
Provisions covered:
Disease definition, surveillance requirements, import conditions, criteria for free country or zone status, compartment establishment, containment measures
Year:
Not specified
Region / City:
United Kingdom
Document Type:
Training syllabus
Organization:
Approved Part 147 Maintenance Training Organization
Approval Number:
UK.147
Course Title:
Basic and Advanced Aircraft Maintenance
Course Reference:
Not specified
Total Duration Theoretical Basic Training:
Varies by module
Total Duration Practical Basic Training:
Varies by module
Theoretical/Practical Ratio:
30% practical in actual maintenance environment
Modules Covered:
Mathematics, Physics, Electrical Fundamentals, Electronic Fundamentals, Digital Techniques, Materials and Hardware, Maintenance Practices, Basic Aerodynamics, Human Factors, Aviation Legislation, Turbine Aeroplane Aerodynamics, Structures and Systems, Gas Turbine Engine, Propeller
Date of Creation/Revision:
Not specified
Training Provider:
Part 147 organization or subcontracted Maintenance Organisation
Target Audience:
Aircraft maintenance personnel and trainees