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Peer-reviewed experimental research article examining IL-4/HB-EGF-dependent signalling between eosinophils and macrophages in mouse models of liver ischaemia reperfusion injury and its role in hepatic regeneration.
Year: 2024
Journal: Gut
Volume: 73
Pages: 1543–1553
DOI: 10.1136/gutjnl-2024-332033
Authors: Yang Y; Xu L; Atkins C; et al.
Topic: Liver regeneration; ischaemia reperfusion injury; immunology; transplantation
Study Type: Experimental research article
Model System: Mouse models of liver injury
Key Molecules: IL-4; IL-13; IL-4Rα; HB-EGF; EGFR
Injury Models: Ischaemia reperfusion injury; paracetamol-induced injury; carbon tetrachloride-induced injury
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Supplementary Information: Therapeutic Potential of MSCs and Their Exosomes in Hepatic Ischaemia Reperfusion Injury — A Systematic Review and Meta-Analysis of Rodent Studies
Authors: Yanxi Mu; Weixiong Zhu; Wentao Ma; Yu Cheng; Bo Ren; Yusheng Cheng; Wence Zhou
Affiliations: The Second Clinical Medical College, Lanzhou University, Lanzhou, China; Department of General Surgery, Biotherapy, Lanzhou University Second Hospital, Lanzhou, China; Gansu Province Precision Diagnosis and Treatment Engineering Research Center of Hepatobiliary Pancreatic Diseases; Gansu Province Key Laboratory of Environmental Oncology, Lanzhou, China
Corresponding authors: Yusheng Cheng; Wence Zhou
Running head: MSCs and Exosome Therapy in HIRI
Type of document: Supplementary information to a systematic review and meta-analysis
Subject: Mesenchymal stem cells and exosomes in hepatic ischaemia reperfusion injury
Study design: Systematic review and meta-analysis of rodent studies
Databases searched: PubMed; Web of Science; Embase; Cochrane Library; ClinicalTrials.gov
Outcomes assessed: ALT; AST; Suzuki’s score; necrotic area ratio; serum TNF-α; cleaved caspase-3
Experimental model: 70% hepatic ischaemia reperfusion injury with 60 or 90 minutes of ischemia in rodents
Content elements: Funnel plots; forest plots; search strategies; summary of mechanisms and outcome data
Topics: IL-4HB-EGF-Dependent Eosinophils Reperfusion