№ files_lp_4_process_3_097791
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Original research article analyzing the expression and functional roles of CR3 and CR4 β2-integrins in human B lymphocytes and CLL B cells, focusing on adhesion, migration, and proliferation patterns.
Year: 2026
Region / city: Budapest, Hungary
Subject: Immunology, B lymphocytes, β2-integrins
Document type: Research article
Institution: Eötvös Loránd University, MTA-ELTE Immunology Research Group
Authors: Zsuzsa Nagy-Baló, Szilvia Lukácsi, Bernadett Mácsik-Valent, Zsuzsa Bajtay, Anna Erdei
Target audience: Immunologists, hematologists, biomedical researchers
Methodology: Flow cytometry, confocal microscopy, transwell migration assay, proliferation assay
Sample: Human B cells and B cell chronic lymphocytic leukemia (CLL) cells
Key findings: CR4 dominates adhesion to fibrinogen and contributes to migration of CLL B cells; adhesion enhances proliferation in CLL B cells
Significance: Potential role of CR4 in disease progression of CLL
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