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Structured evaluation scale defining criteria and scoring used to assess methodological quality in molecular association studies examining genetic relationships with osteoporosis.
Document type:
Assessment scale table
Research field:
Genetic epidemiology
Topic:
Molecular association studies and osteoporosis
Assessment criteria:
Source of case, Source of control, Ascertainment of osteoporosis, Ascertainment of control, Matching, Genotyping examination, Specimens used for determining genotypes, Hardy-Weinberg Equilibrium, Association assessment, Total sample size
Scoring system:
Point-based evaluation scale
Maximum score components:
Up to 3 points per criterion depending on category
Population focus:
Osteoporosis cases and controls
Diagnostic reference:
WHO (World Health Organization) diagnostic standards
Statistical considerations:
Assessment of genotype–osteoporosis associations with appropriate statistics and adjustment for confounders
Genetic analysis method:
Genotyping with blinding and quality control considerations
Sample material types:
Blood cells, normal tissues, tumor tissues, exfoliated tissue cells
Sample size categories:
<200, 200–500, >500
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Year:
2024
Region / city:
UK
Topic:
Osteoporosis, fracture prevention, evidence-based resources
Document type:
Guidance
Organization / institution:
Royal Osteoporosis Society, Keele University
Author:
Not specified
Target audience:
Researchers, clinicians, patients, healthcare professionals
Period of validity:
Not specified
Approval date:
Not specified
Date of changes:
Not specified
Year:
2023
Region / city:
England
Topic:
Health, General Practice
Document Type:
Business Rules
Organization:
NHS England
Author:
General Practice Specification and Extraction Service (GPSES)
Target Audience:
GP system suppliers, GP practices
Period of Validity:
2023/2024/2425
Approval Date:
01/04/2023
Date of Amendments:
01/04/2024
Year:
2020
Country:
Australia
Subject:
Osteoporosis pharmacotherapy
Focus medicine:
Denosumab
Other medicines included:
Bisphosphonates, raloxifene, teriparatide, strontium ranelate, calcitriol
Type of document:
Drug utilisation analysis report
Data sources:
Pharmaceutical Benefits Scheme (PBS) data, MedicineInsight data
Committee:
Drug Utilisation Sub-Committee (DUSC)
Study design:
Retrospective cohort analysis
Population:
Patients aged 50 years and over
Study period:
January 2012 – June 2019 (PBS); January 2014 – December 2017 (MedicineInsight cohorts)
Geographic scope:
National
Health system context:
Pharmaceutical Benefits Scheme
Contextual description:
Analytical health policy report examining national prescribing patterns, initiation, discontinuation, and subsequent therapy use of denosumab and other osteoporosis medicines based on linked administrative and general practice data.
Year:
Not specified
Region / City:
Hawkes Bay
Topic:
Osteoporosis Treatment
Document Type:
Medical guideline
Organization:
PHARMAC
Author:
Not specified
Target Audience:
Healthcare professionals
Effective Period:
Not specified
Approval Date:
Not specified
Amendment Date:
Not specified
Year:
2021
Region / City:
Not specified
Topic:
Osteoporosis Screening Installation
Document Type:
Installation Guide
Organization / Institution:
Department of Veterans Affairs, Office of Information Technology
Author:
Not specified
Target Audience:
VA staff, healthcare providers
Period of validity:
Not specified
Approval Date:
March 2021
Date of Changes:
Not specified
Topic:
Osteoporosis and bone health
Document Type:
Information sheet
Subject Area:
Health education
Medical Condition:
Osteoporosis
Related Condition:
Osteopenia
Screening Method:
DEXA scan (Dual Energy X-ray Absorptiometry)
Diagnostic Indicator:
T-score classification
Target Audience:
Healthcare staff and caregivers supporting individuals at risk of fractures
Referenced Organizations:
National Osteoporosis Foundation; U.S. Preventive Services Task Force
Referenced Guideline Year:
2018
Key Risk Factors:
Age over 50, female gender, family history, chronic diseases, certain medications
Diagnostic Criteria:
Bone density testing with T-score thresholds
Treatment Options:
Bisphosphonates, calcitonin, hormone-related medications, surgical intervention in rare cases
Care Considerations:
Safe transfers, fracture prevention, assistive lifting equipment for individuals with fragile bones
Document section:
Supplementary table S4
Subject:
ESR1 G2014A gene polymorphism and osteoporosis risk
Academic field:
Genetic epidemiology
Type of document:
Supplementary scientific table
Study design:
Meta-analysis of case–control studies
Population characteristics:
Female participants with specified menopausal status
Countries represented:
Mexico; Thailand
Geographic regions:
South America; East Asia
Ethnicity groups:
Mixed; Asian
Control source:
Population-based (PB); Hospital-based (HB)
Genetic focus:
ESR1 G2014A polymorphism
Variables reported:
Genotype distribution; allele distribution; minor allele frequency; Hardy–Weinberg equilibrium p-value
Sample information:
Cases and controls with genotype counts (A/A, A/G, G/G)
Total samples reported:
640; 228; 358; 352; 66
Authors cited:
Gómez R et al.; Ongphiphadhanakul B et al.; Wajanavisit et al.
Years of referenced studies:
2001; 2003; 2005; 2007; 2015
Year:
2026
Institution:
Queen Margaret University
Department:
Centre for Person-centred Practice Research
Project Title:
Lydia X Osteoporosis Project
Funding:
Gateway awards scheme
Project Phase:
Fourth phase
Research Focus:
Osteoporosis prevention, living with osteoporosis, healthcare practitioner knowledge and skills
Methodology:
Person-centred research, experience-based co-design study, knowledge exchange
Team Members:
Erna Haraldsdottir, Gemma Stevenson, Vicki Waga, Research Assistant (starting January 2026)
Opportunities:
Meetings attendance, data collection, data management, analysis, ethics applications, dissemination activities, knowledge exchange with staff and students
Target Audience:
Health care professionals, students, people living with osteoporosis
Start Date:
April 2026
Mentors:
Gemma Stevenson, Vicki Waga, Erna Haraldsdottir
Community Engagement:
Networking and educational meetings for patients and professionals
Year:
2020
Region / City:
West Lafayette, IN
Subject:
Biochemistry, Molecular Biosciences
Document Type:
Syllabus
Institution:
Purdue University
Author:
Dr. Pete E. Pascuzzi
Target Audience:
Students enrolled in BCHM 421R
Period of Validity:
Fall 2020
Date of Approval:
Not specified
Date of Changes:
Not specified
Year:
2015–2016
Location:
Various (Mexico City, Natal, Mpumalanga, Cambridge, Geneva, Moscow, Paris)
Organization:
International Union for the Protection of New Varieties of Plants (UPOV)
Document type:
Report
Prepared by:
Office of the Union
Event:
Technical Working Parties sessions, BMT sessions, OECD/UPOV/ISTA Joint Workshop
Target audience:
UPOV members and general public
Dates of events:
June 2, 2016; July 11–15, 2016; June 30–July 2, 2015; August 24–28, 2015; September 14–18, 2015; March 14–16, 2016; May 24–27, 2016; June 8, 2016
Focus:
Use of molecular markers for variety identification, DUS examination, and plant breeder’s rights enforcement
Year:
2018
Region / City:
Not specified
Subject:
Molecular Biology, DNA quantification
Document Type:
Laboratory Experiment
Organization / Institution:
Not specified
Author:
Not specified
Target Audience:
Students, Researchers in Molecular Biology
Validity Period:
Not specified
Approval Date:
Not specified
Modification Date:
Not specified
Year:
2020
Region / City:
International
Topic:
Biochemical and Molecular Markers, Plant Varieties
Document Type:
Draft
Organization / Institution:
International Union for the Protection of New Varieties of Plants (UPOV)
Author:
UPOV Office
Target Audience:
Technical Committee, Administrative and Legal Committee, and Council of UPOV
Effective Period:
2020
Approval Date:
August 10, 2020
Date of Changes:
Not specified
Context:
Guidance document outlining methods for using biochemical and molecular markers to assess distinctness, uniformity, and stability of new plant varieties for UPOV compliance.
Year:
2023
Region / City:
Sunnybrook Health Sciences Centre
Theme:
Quality Management System
Document Type:
Guideline
Organization / Institution:
Sunnybrook Health Sciences Centre
Author:
Not specified
Target Audience:
Laboratory personnel, healthcare professionals
Period of validity:
Ongoing
Approval Date:
June 2023
Date of changes:
August 2023
Year:
2025
Region / City:
N/A
Subject:
Molecular MRI Biomarkers, Research Funding
Document Type:
Application Instructions and Checklist
Institution:
N/A
Author:
N/A
Target Audience:
Principal Investigators, Researchers in the field of Molecular MRI
Effective Period:
N/A
Approval Date:
N/A
Date of Changes:
N/A
Year:
2023
Region / City:
United Kingdom
Topic:
Molecular Diagnostics, Fetal Blood Group Genotyping
Document Type:
Referral Form
Organ / Institution:
NHS Blood and Transplant
Author:
NHS Blood and Transplant
Target Audience:
Healthcare Providers, Medical Professionals
Effective Period:
Ongoing
Approval Date:
Not specified
Amendment Date:
Not specified
Year:
2022
Region / City:
Orlando, Florida
Subject:
Molecular Biology
Document Type:
Syllabus
Institution:
University of Central Florida
Author:
Kersten Schroeder, Ph.D.
Target Audience:
Students enrolled in the course
Duration:
Spring 2022
Approval Date:
2022
Date of Last Update:
January 2022
Course Prerequisites:
CHM 2211, MCB 3020C
Required Textbook:
Molecular Biology: Principles and Practice (2nd Edition): Cox, Doudna, & O’Donnell. W. H. Freeman, ISBN: 978-1-319-05280-5
Supplemental Textbook:
Molecular Biology of the Gene (7th Edition): James D. Watson. Benjamin Cummings, ISBN 978-0321762436
Course Website:
WebCourses
Description:
Syllabus for a university course outlining the curriculum and grading structure for Molecular Biology I, detailing specific topics in genetics, biochemistry, and molecular biology techniques.
Year:
2023-2024
Region / City:
Las Vegas, NV
Subject:
Biological Sciences - Cellular and Molecular Biology
Document Type:
Educational Catalog
Institution:
University of Nevada, Las Vegas
Target Audience:
Graduate Students
Period of Action:
2023-2024
Approval Date:
N/A
Modification Date:
N/A
Year:
2015
Region / City:
N/A
Theme:
Molecular Ecology, Fungal Studies
Document Type:
Research Protocol
Organization:
Kennedy Lab
Authors:
Nhu Nguyen, Peter Kennedy
Target Audience:
Researchers in molecular ecology and fungal studies
Effective Period:
N/A
Approval Date:
N/A
Date of Changes:
April 22, 2015
Year:
2020
Note:
Region / city
Topic:
Molecular diagnostics, laboratory accreditation
Document type:
Application form
Organization / institution:
IFCC
Target audience:
Laboratories, researchers, and experts in molecular diagnostics
Context:
A form for applying to become an IFCC MDC Expert Laboratory, outlining required details such as applicant information, laboratory accreditation, and areas of interest in molecular diagnostics.
Year:
2020
Region / City:
Not specified
Topic:
Molecular diagnostics, accreditation, proficiency testing
Document Type:
Application Form
Organization / Institution:
IFCC (International Federation of Clinical Chemistry and Laboratory Medicine)
Author:
Not specified
Target Audience:
Molecular diagnostic laboratories
Effective Period:
Not specified
Approval Date:
Not specified
Date of Changes:
Not specified