№ files_lp_4_process_3_113781
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Scientific medical overview describing mechanisms, risk factors, clinical manifestations, complications, and diagnostic approaches of venous thromboembolism with discussion of P-selectin as a biomarker associated with thrombotic processes.
Subject:
Venous thromboembolism and P-selectin biomarker
Field:
Hematology and vascular medicine
Document type:
Scientific article abstract and overview
Topics covered:
Risk factors, pathogenesis, clinical features, complications, and diagnosis of venous thromboembolism
Biological marker discussed:
P-selectin
Medical conditions referenced:
Deep vein thrombosis (DVT), pulmonary embolism (PE), chronic thromboembolic pulmonary hypertension (CTEPH)
Diagnostic methods mentioned:
Wells score, ultrasonography, computed tomography pulmonary angiography, ventilation-perfusion scan, plethysmography, D-dimer testing, contrast venography, magnetic resonance imaging
Genetic factors referenced:
Antithrombin deficiency, protein C deficiency, protein S deficiency, factor V Leiden, prothrombin G20210A mutation
Physiological mechanisms:
Virchow’s triad, endothelial damage, venous stasis, hypercoagulability
Clinical signs referenced:
Homans sign, Louvel sign, Lowenberg sign
Figures referenced:
Flowchart of thrombosis process and diagnostic pathway for venous thromboembolism
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The product description is provided for reference. Actual content and formatting may differ slightly.
Year:
2026
Research area:
Molecular and cellular biology
Document type:
Experimental figure legend / data description
Organism / system:
Human cell lines
Methods:
Western blot, immunoprecipitation
Proteins studied:
ICAM-1, VCAM-1, P-Selectin, β-actin, Ikbα, p65, GATA2, PP2AC, CSN5, COP1, Fbw7
Figure numbers:
2A, 3A, 3F, 3G, 3M, 5A, 5E, 5I, 6A, 6B, 7A, 7B, 7E, 7J, 9A, 9B
Data type:
Protein expression and interaction data
Year:
[year]
Region / City:
[region]
Topic:
Anticoagulation, Venous Thromboembolism, Kidney Disease
Document Type:
Clinical Practice Guideline
Institution / Organization:
UK Kidney Association
Author:
Kathrine Parker, Albert Power, Yvonne Bernes, Kate Bramham, Richard Buka, Satarupa Choudhuri, Mark Davies, Maria A Gauci, Lauren Hall, Alan Hancock, John Hartemink, Ed Jenkinson, Nicola Korn, Donna Lewis, Gregory Y.H. Lip, Katy Mills, Anneka Mitchell, Lara Roberts, Huw Rowswell, Hannah Stacey, Katherine Stirling, Jecko Thachil, Jung Tsang, Isaac Tseng
Target Audience:
Healthcare professionals in nephrology, haematology, and related fields
Period of Application:
Ongoing
Approval Date:
[month] [year]
Amendment Date:
[month] [year]
Document type:
Clinical guideline appendix
Chapter:
8 Plastic Surgery
Appendix:
1
Subject:
Perioperative venous thromboembolism prophylaxis
Content:
Summary of the quality of studies
Focus:
Deep vein thrombosis (DVT) and pulmonary embolism (PE)
Population:
Patients undergoing plastic and reconstructive surgery
Interventions:
Chemoprophylaxis, mechanical prophylaxis, risk assessment models, anticoagulation strategies
Outcomes:
DVT incidence, VTE incidence, bleeding rate, free flap failure rate, mortality
Risk of bias assessment:
Low, Intermediate, High
Studies included:
Observational studies and comparative studies
Update status:
First update
Department:
Heamatology/Orthopaedic/Pharmacy
Target audience:
Parents and carers of hospitalised children aged 13 and above
Risks:
Deep Vein Thrombosis, Pulmonary Embolism, Cerebral Venous Sinus Thrombosis
Preventive measures:
Mobility, hydration, physiotherapy, risk assessment, medication, compression stockings
Medication:
Enoxaparin (Clexane®), subcutaneous injection, anticoagulant
Instructions:
Dosage, administration guidance, sharps disposal
Emergency signs:
Swelling, pain, breathlessness, chest pain, severe headache, fits, vomiting, weakness
Setting:
Hospital, Alder Hey Children’s NHS Foundation Trust
Region:
United Kingdom
Type of document:
Patient information leaflet
Year:
2026
Region / city:
Belgrade, Serbia; London, UK
Topic:
Atrial fibrillation, Renal failure, Thromboembolism, Bleeding management
Document type:
Academic article
Author:
Tatjana Potpara, A. John Camm
Target audience:
Healthcare professionals, Researchers
Period of validity:
N/A
Date of approval:
N/A
Date of amendments:
N/A
Context:
This academic article discusses the management of thromboembolic and bleeding risks in end-stage renal disease patients with atrial fibrillation, comparing anticoagulants and left atrial appendage closure.
Year:
2013–2022
Region / Country:
England and Wales
Topic:
Thromboembolism-related deaths
Document Type:
Supplementary Appendix to systematic case series
Institution:
Judiciary of England and Wales
Author:
Not specified
Data Source:
NHS England Digital, Office for National Statistics
Target Audience:
Healthcare professionals, coroners, researchers
Geographic Scope:
National
Time Period Covered:
2013–2022
Data Categories:
Yearly PFD counts, thromboembolism-related PFDs, thromboembolism deaths, location of events, coroner area, administrative regions, Judiciary categories
Year:
2026
Region / City:
International cohorts (UK, USA, Germany, Sweden, Japan, Italy, Netherlands, Canada, Finland, Spain, Australia)
Topic:
Cardiovascular risk factors and venous thromboembolism
Document Type:
Research article
Organization / Institution:
Emerging Risk Factors Collaboration, UK Biobank
Authors:
John Gregson, Stephen Kaptoge, Thomas Bolton, Lisa Pennells, Peter Willeit, Stephen Burgess, Steven Bell, Michael Sweeting, Eric B Rimm, Christopher Kabrhel, Bengt Zöller, Gerd Assmann, Vilmundur Gudnason, Aaron R Folsom, Volker Arndt, Astrid Fletcher, Paul E Norman, Børge G Nordestgaard, Akihiko Kitamura, Bakhtawar K Mahmoodi, Peter H Whincup, Matthew Knuiman, Veikko Salomaa, Christa Meisinger, Wolfgang Koenig, Maryam Kavousi, Henry Völzke, Jackie A Cooper, Toshiharu Ninomiya, Edoardo Casiglia, Beatriz Rodriguez, Yoav Ben-Shlomo, Jean-Pierre Després, Leon Simons, Elizabeth Barrett-Connor, Cecilia Björkelund, Marlene Notdurfter, Daan Kromhout, Jackie Price, Susan E Sutherland, Johan Sundström, Jussi Kauhanen, John Gallacher, Joline WJ Beulens, Rachel Dankner, Cyrus Cooper, Simona Giampaoli, Jason F Deen, Agustín Gómez de la Cámara, Lewis H Kuller, Annika Rosengren, Peter J Svensson, Dorothea Nagel, Carlos J. Crespo, Hermann Brenner, Juan R. Albertorio-Diaz, Robert Atkins, Eric J Brunner, Martin Shipley, Inger Njølstad, Deborah A Lawlor, Yvonne T van der Schouw, Randi Marie Selmer, Maurizio Trevisan, W M Monique Verschuren, Philip Greenland, Sylvia Wassertheil-Smoller, Gordon D O Lowe, Angela M Wood, Adam S Butterworth, Simon G Thompson, John Danesh, Emanuele Di Angelantonio, Tom Meade
Target Audience:
Researchers, clinicians, epidemiologists
Study Period:
up to 2016
Number of Participants:
1,153,265
Study Design:
Prospective cohort studies
Main Findings:
Older age, smoking, higher adiposity, and lower alcohol consumption are associated with increased risk of venous thromboembolism
Year:
[year]
Region / City:
[region]
Topic:
Anticoagulation, Venous Thromboembolism, Kidney Disease
Document Type:
Clinical Practice Guideline
Institution / Organization:
UK Kidney Association
Author:
Kathrine Parker, Albert Power, Yvonne Bernes, Kate Bramham, Richard Buka, Satarupa Choudhuri, Mark Davies, Maria A Gauci, Lauren Hall, Alan Hancock, John Hartemink, Ed Jenkinson, Nicola Korn, Donna Lewis, Gregory Y.H. Lip, Katy Mills, Anneka Mitchell, Lara Roberts, Huw Rowswell, Hannah Stacey, Katherine Stirling, Jecko Thachil, Jung Tsang, Isaac Tseng
Target Audience:
Healthcare professionals in nephrology, haematology, and related fields
Period of Application:
Ongoing
Approval Date:
[month] [year]
Amendment Date:
[month] [year]
Year:
2010
Region / City:
National (UK)
Theme:
Health, Blood Transfusion, Patient Safety
Document Type:
Competency Assessment Guidelines
Institution:
Skills for Health
Author:
British Society for Haematology, National Patient Safety Agency
Target Audience:
Healthcare Professionals involved in blood transfusion and venepuncture
Period of Validity:
Ongoing (with annual reviews as per local training needs)
Approval Date:
June 2010
Date of Updates:
N/A
Year:
2024
Country:
Scotland
Healthcare system:
NHS
Subject:
Venous leg ulcer management and intervention
Document type:
Clinical pathway and Standard Operating Procedure
Issuing programme:
National Wound Care Strategy Programme
Clinical setting:
Community Venous Leg Ulcer Clinic and Vascular Surgery Service
Target population:
Patients with venous leg ulcers
Related guidance:
NICE guidance; SIGN 120 (withdrawn)
Referenced trials:
ESCHAR trial (2007); EVRA trial (2018)
Contributors:
NHS Tayside clinical team (appendix adaptation)
Services involved:
Primary Care, District Nursing, Vascular Surgery, Dermatology
Procedures included:
ABPI measurement, compression therapy, venous duplex, endovenous ablation, sclerotherapy, surgical stripping
Referral pathway:
Community clinic triage and one-stop vascular clinic referral
Period of applicability:
From July 2024
Year:
1986–2023
Type:
Literature review / reference compilation
Topic:
Central venous catheterization, mechanical complications, training, ultrasound guidance
Authors:
Walsh EC, Fitzsimons MG, Gibson F, Bodenham A, Bannon M, Heller, Rivera, Adrian M, Borgquist O, Kröger T, Domino KB, Lee LA, Sznajder JI, Zveibil FR, Bitterman H, Weiner P, Bursztein S, Barsuk JH, Cohen ER, Feinglass J, McGaghie WC, Wayne DB, Moureau N, Lamperti M, Kelly LJ, Koh J, Xu Y, Yeo L, Soffler MI, Hayes MM, Smith CC, Peltan ID, Shiga T, Gordon JA, Currier PF, Ma IWY, Brindle ME, Ronksley PE, Lorenzetti DL, Sauve RS, Ghali WA, Duncan JR, Henderson K, Street M, McGee DC, Schummer W, Schummer C, Rose N, Niesen WD, Sakka SG, Milling TJ, Rose J, Briggs WM, Troianos CA, Jobes DR, Ellison N, Leung J, Duffy M, Finckh A, Bansal R, Agarwal SK, Tiwari SC, Dash SC, Mallory DL, McGee WT, Shawker TH, Brass P, Hellmich M, Kolodziej L, Schick G, Gualtieri E, Deppe SA, Sipperly ME, Thompson DR, Fragou M, Gravvanis A, Dimitriou V, Aouad MT, Kanazi GE, Abdallah FW, Ablordeppey EA, Drewry AM, Beyer AB, Bodenham Chair A, Babu S, Bennett J, Parienti JJ, Mongardon N, Mégarbane B, Mira JP, Kalfon P, Gros A, Marqué S, Thuong M, Pottier V, Ramakers M, Savary B, Seguin A, Valette X, Terzi N, Sauneuf B, Cattoir V, Mermel LA, du Cheyron D, Chen HE, Sonntag CC, Pepley DF, Prabhu RS, Han DC, Moore JZ, Miller SR, Yovanoff MA, Mirkin KA, Mohamadipanah H, Parthiban C, Nathwani J, Rutherford D, DiMarco S, Pugh C, Clinkard D, Holden M, Ungi T, Messenger D, Davison C, Fichtinger G, McGraw R
Source type:
Scientific journal articles
Period covered:
1986–2023
Medical field:
Anesthesiology, intensive care, surgery
Focus:
Mechanical complications, central venous catheter placement, procedural training, simulation, ultrasound guidance
Year:
2026
Region / City:
N/A
Topic:
Medical Procedure
Document Type:
Consent Form
Institution:
N/A
Author:
N/A
Target Audience:
Patients undergoing laser venous ablation therapy
Validity Period:
N/A
Approval Date:
N/A
Amendment Date:
N/A
Document type:
Clinical guideline appendix
Chapter:
8 Plastic Surgery
Appendix:
1
Subject:
Perioperative venous thromboembolism prophylaxis
Content:
Summary of the quality of studies
Focus:
Deep vein thrombosis (DVT) and pulmonary embolism (PE)
Population:
Patients undergoing plastic and reconstructive surgery
Interventions:
Chemoprophylaxis, mechanical prophylaxis, risk assessment models, anticoagulation strategies
Outcomes:
DVT incidence, VTE incidence, bleeding rate, free flap failure rate, mortality
Risk of bias assessment:
Low, Intermediate, High
Studies included:
Observational studies and comparative studies
Update status:
First update
Note:
Year
Year:
2026
Region / City:
Houston, TX
Topic:
Spaceflight, Fluid Dynamics, Venous Blood Flow
Document Type:
Research Study
Organization / Institution:
NASA Johnson Space Center
Author:
K. Marshall-Goebel, J. Lytle, D. Martin, S.S. Laurie, C. Miller, S.M.C. Lee, M. Young, B.R. Macias
Target Audience:
Researchers, Spaceflight Medical Personnel
Date of Approval:
2026
Date of Changes:
N/A
Year:
2026
Region / city:
Edinburgh, UK
Topic:
Veterinary Medicine, Cardiology, Canine Health
Document type:
Case Report
Author:
E.F. Bode, M. Longo, C. Breheny, J. Del-Pozo, G. Culshaw, Y. Martinez-Pereira
Target audience:
Veterinarians, Animal Health Researchers
Date of approval:
Not specified
Date of revisions:
Not specified
Department:
Heamatology/Orthopaedic/Pharmacy
Target audience:
Parents and carers of hospitalised children aged 13 and above
Risks:
Deep Vein Thrombosis, Pulmonary Embolism, Cerebral Venous Sinus Thrombosis
Preventive measures:
Mobility, hydration, physiotherapy, risk assessment, medication, compression stockings
Medication:
Enoxaparin (Clexane®), subcutaneous injection, anticoagulant
Instructions:
Dosage, administration guidance, sharps disposal
Emergency signs:
Swelling, pain, breathlessness, chest pain, severe headache, fits, vomiting, weakness
Setting:
Hospital, Alder Hey Children’s NHS Foundation Trust
Region:
United Kingdom
Type of document:
Patient information leaflet
Year:
2026
Region / City:
International cohorts (UK, USA, Germany, Sweden, Japan, Italy, Netherlands, Canada, Finland, Spain, Australia)
Topic:
Cardiovascular risk factors and venous thromboembolism
Document Type:
Research article
Organization / Institution:
Emerging Risk Factors Collaboration, UK Biobank
Authors:
John Gregson, Stephen Kaptoge, Thomas Bolton, Lisa Pennells, Peter Willeit, Stephen Burgess, Steven Bell, Michael Sweeting, Eric B Rimm, Christopher Kabrhel, Bengt Zöller, Gerd Assmann, Vilmundur Gudnason, Aaron R Folsom, Volker Arndt, Astrid Fletcher, Paul E Norman, Børge G Nordestgaard, Akihiko Kitamura, Bakhtawar K Mahmoodi, Peter H Whincup, Matthew Knuiman, Veikko Salomaa, Christa Meisinger, Wolfgang Koenig, Maryam Kavousi, Henry Völzke, Jackie A Cooper, Toshiharu Ninomiya, Edoardo Casiglia, Beatriz Rodriguez, Yoav Ben-Shlomo, Jean-Pierre Després, Leon Simons, Elizabeth Barrett-Connor, Cecilia Björkelund, Marlene Notdurfter, Daan Kromhout, Jackie Price, Susan E Sutherland, Johan Sundström, Jussi Kauhanen, John Gallacher, Joline WJ Beulens, Rachel Dankner, Cyrus Cooper, Simona Giampaoli, Jason F Deen, Agustín Gómez de la Cámara, Lewis H Kuller, Annika Rosengren, Peter J Svensson, Dorothea Nagel, Carlos J. Crespo, Hermann Brenner, Juan R. Albertorio-Diaz, Robert Atkins, Eric J Brunner, Martin Shipley, Inger Njølstad, Deborah A Lawlor, Yvonne T van der Schouw, Randi Marie Selmer, Maurizio Trevisan, W M Monique Verschuren, Philip Greenland, Sylvia Wassertheil-Smoller, Gordon D O Lowe, Angela M Wood, Adam S Butterworth, Simon G Thompson, John Danesh, Emanuele Di Angelantonio, Tom Meade
Target Audience:
Researchers, clinicians, epidemiologists
Study Period:
up to 2016
Number of Participants:
1,153,265
Study Design:
Prospective cohort studies
Main Findings:
Older age, smoking, higher adiposity, and lower alcohol consumption are associated with increased risk of venous thromboembolism