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Supplementary scientific materials containing figures, tables, datasets and methodological notes describing genome-wide analyses of interactions between genetic variants in the FMN1/GREM1 region and body mass index in relation to colorectal cancer risk.
Document Type: Supplementary research materials
Scientific Field: Genetic Epidemiology
Research Topic: Gene–body mass index interactions in colorectal cancer risk
Genes / Locus Studied: FMN1, GREM1, rs58349661
Methods: Genome-wide interaction analysis, SNP association tests, EDGE two-step procedure
Statistical Elements: 1DF and 3DF tests, odds ratios, confidence intervals, principal components analysis
Figures: Q-Q plots, Manhattan plots, SNP interaction plots, functional annotation plots
Tables: Participant descriptions, sample sizes by subtype and center, SNP association results, BMI-stratified analyses, gene expression interaction results
Data Sources: Multiple international colorectal cancer studies and cohorts
Study Designs Included: Cohort, case-control, case-series
Countries Represented: USA, Canada, Australia, Finland, Austria, Spain, Czech Republic, Germany, United Kingdom and other European cohorts
Genotyping Platforms: Illumina Oncoarray, Illumina OmniExpress, Illumina OmniExpressExome, Illumina 300K, Illumina 1M, Affymetrix Axiom
Population: Participants from international colorectal cancer genetic studies
Content Sections: Figures S1–S5, Tables S1–S7, Supplementary Methods, Funding and Acknowledgements
Price: 8 / 10 USD
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Activity: Implementation Drivers Locus of Responsibility
Type of document: Organizational self-assessment activity guide
Subject: Implementation Drivers and locus of responsibility
Purpose: Assessment and action planning for implementation capacity
Intended audience: Teams within systems or organizations implementing programs, practices, or innovations
Scope: Organizational systems and implementation processes
Structure: Mapping exercise, reflection questions, action planning prompts
Key concepts: Direct control, influence, no control, integration of Drivers
Application context: Existing program, practice, or innovation within a system
Supplementary MaterialsSupplementary Figure 1. Locus zoom plots for 35 novel loci (selected from Table 1)
Note: Year
Author: MEGASTROKE CONSORTIUM
Topics: FMN1GREM1 Interacts Locus