№ files_lp_3_process_7_096945
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Supplementary scientific material presenting experimental data and methodological details on the role of HES1 in myeloid cells and its impact on macrophage function and cytotoxic T cell infiltration in murine tumor models.
Authors: Myung Sup Kim; Hyeokgu Kang; Jung-Hwan Baek; Moon-Gyu Cho; EunJoo Chung; Seok-Jun Kim; Joon-Yong Chung; Kyung-Hee Chun
Corresponding author: Kyung-Hee Chun
Affiliation: Department of Biochemistry & Molecular Biology, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul, Republic of Korea
Additional institutions: Institute of Genetic Science, Yonsei University College of Medicine; National Cancer Institute, National Institutes of Health, Bethesda, MD, USA; Chosun University, Gwangju, Republic of Korea
Region / Country: Republic of Korea; United States of America
Type of document: Supplementary figures and experimental descriptions for a biomedical research article
Field of study: Cancer immunology; molecular and cellular biology
Key topics: Notch signaling; HES1; macrophage differentiation; tumor-associated macrophages; CD8+ T cells; MMTV-PyMT mouse model; TC-1 tumor model
Experimental models: Murine spontaneous and subcutaneous tumor models; MMTV-PyMT mice; LysM-Hes1 conditional knockout mice; BMDMs; THP-1 cells
Methods: Flow cytometry; qRT-PCR; RNA sequencing; Western blotting; luciferase reporter assay; immunohistochemistry; antibody-mediated depletion
Genes and proteins analyzed: HES1; NICD; INOS; STAT6; Arg1; RBPJ; IFNγ; CD4; CD8
Supplementary material: Figures S1–S10
Contact information: Department of Biochemistry & Molecular Biology, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul 03722, Korea; Phone: 82-2-2228-1699; E-mail: [email protected]
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