№ files_lp_4_process_3_132627
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The document contains supplementary data tables and figures related to diagnostic codes, characteristics of patients with metastatic gynecologic cancer, and the use of invasive mechanical ventilation in combination with palliative care.
Year:
2026
Region / city:
Not specified
Topic:
Medical research, oncology, palliative care
Document type:
Supplementary material
Organization:
Not specified
Author:
Not specified
Target audience:
Medical researchers, healthcare professionals
Period of validity:
Not specified
Date of approval:
Not specified
Date of changes:
Not specified
Price: 8 / 10 USD
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Note:
Year
Document Type:
Lesson Plan
Target Audience:
Students
Year:
2020
Region / City:
Neuquén, Argentina
Topic:
Gynecologic cancer, radiotherapy, dose optimization
Document type:
Research article
Organization / Institution:
Centro Oncológico Integral, Fundación Médica de Río Negro y Neuquén
Authors:
M. Bertero, R. González Armesto, J. De Brida, M. S. Gallo, R. Ruggeri
Target Audience:
Medical professionals, oncologists, researchers in radiotherapy
Period of validity:
N/A
Approval date:
N/A
Date of modifications:
N/A
Version:
1.1.0.0
Protocol Posting Date:
March 2023
Year:
2023
Region / City:
Not specified
Topic:
Gynecologic cancer biomarker testing
Document Type:
Protocol
Organization / Institution:
Not specified
Author:
Barbara A. Crothers, DO; Lara R. Harik, MD, FCAP; Angela N. Bartley, MD, PhD, FCAP; Russell R. Broaddus, MD, PhD, FCAP; Linus T. Chuang, MD; Michael B. Cohen, MD; Patricia Salter Jamieson, CTR; Elke A. Jarboe, MD; Teri A. Longacre, MD; George L. Mutter, MD; Christopher N. Otis, MD; Patrick L. Fitzgibbons, MD, FCAP; Richard Zaino, MD; Gulisa Turashvili, MD, PhD; Krisztina Hanley, MD.
Target Audience:
Laboratories performing biomarker testing
Effective Period:
Not specified
Approval Date:
March 2023
Date of Changes:
Version 1.1.0.0
Version History:
Updated to include "COMMENT" section and revised notes
Year:
N/A
Region / City:
N/A
Theme:
Gynecology
Document Type:
Medical Source
Organization / Institution:
N/A
Author:
N/A
Target Audience:
Healthcare professionals
Period of Action:
N/A
Approval Date:
N/A
Date of Changes:
N/A
Year:
2026
Study type:
Supplementary material
Cohort size:
93 patients
Disease:
Metastatic melanoma
Methods:
Multiplex immunofluorescence, image cytometry, Cox regression, LASSO analysis
Data type:
Tables and figures
Variables analyzed:
Clinicopathologic characteristics, cell density, proximity measurements, immune biomarkers
Statistical software:
R
Target population:
Patients with metastatic melanoma
Follow-up period:
5 years
Year:
2024
Region / city:
Global
Theme:
Oncology, Endometrial Cancer, Pharmaceutical Submissions
Document Type:
Medical Submission
Organization / Institution:
AstraZeneca Pty Ltd
Author:
AstraZeneca Pty Ltd
Target Audience:
Medical professionals, regulatory bodies, pharmaceutical companies
Period of validity:
Not specified
Approval Date:
Not specified
Modification Date:
Not specified
Year:
2023
Region / City:
Australia
Topic:
Oncology, Pharmaceutical Submission
Document Type:
Pharmaceutical Resubmission
Organization:
AstraZeneca Pty Ltd
Author:
Not specified
Target Audience:
Medical Practitioners
Period of Validity:
Ongoing
Approval Date:
Not specified
Date of Changes:
Not specified
Context:
A pharmaceutical resubmission document outlining the use of osimertinib as a first-line treatment for locally advanced or metastatic EGFRm non-small cell lung cancer (NSCLC) in Australia, including previous PBAC considerations and clinical trial data.
Year:
2025
Date:
October 30, 2025
Time:
5:00 PM
Field:
Oncology; Surgery
Topic:
Tumor-Infiltrating Lymphocyte (TIL) Therapy; Metastatic Melanoma
Document Type:
Continuing Education / Continuing Medical Education Activity Description
Organizing Institution:
Ascension
Accrediting Bodies:
Accreditation Council for Continuing Medical Education; Accreditation Council for Pharmacy Education; American Nurses Credentialing Center
Credit Designation:
1.50 IPCE credits; 1.50 ANCC contact hours
Target Audience:
Interdisciplinary healthcare team; Oncology and Surgery specialties
Faculty:
Jatandra Birney, PharmD, BCOP
Activity Coordinator:
Tari Hopper, BSN
Commercial Support:
None
Conflict of Interest Disclosure:
No relevant financial relationships disclosed
Year:
2026
Region / City:
Not specified
Topic:
Cancer genomics, epigenetics, prostate cancer
Document type:
Supplementary material
Institution:
Not specified
Authors:
Chennan Li et al.
Target audience:
Researchers in oncology and molecular biology
Sample type:
Plasma and buffy coat
Methods:
ctDNA sequencing, 5mC/5hmC methylomics, clonal reconstruction
Timepoints:
Baseline, restaging, progression, off-study
Genes analyzed:
AR, BRCA2, erythroid markers, platelet/megakaryocyte markers, globins
Data included:
Sequencing metrics, methylation percentages, gene-level events, survival analysis
Associated figures:
8 supplementary figures, 2 supplementary tables
Statistical analyses:
Spearman correlation, Kruskal-Wallis test, Mann-Whitney U test, Kaplan-Meier survival estimates, log-rank test
Year:
[Insert year]
Region / city:
[Insert region/city]
Subject:
Medical treatment request
Document type:
Authorization request letter
Institution:
[Insert institution name]
Author:
[Physician’s name]
Target audience:
Medical/Pharmacy Director
Effective period:
[Insert effective period]
Approval date:
[Insert approval date]
Date of modifications:
[Insert modification date]
Diagnosis:
[Insert diagnosis]
Treatment:
ERLEADA® (apalutamide)
Clinical trial:
TITAN trial
Clinical guidelines reference:
NCCN Guidelines®, AUA/SUO Guidelines
Patient history:
[Insert patient history]
Risk of disease progression:
[Insert risk]
Adverse reactions:
Rash, hot flush, hypertension, arthralgia, pruritus
Publication reference:
Journal of Clinical Oncology
Study data source:
Precision Point Specialty (PPS) Analytics, Komodo Research Database
Study design:
Retrospective, longitudinal, head-to-head analysis
Outcome:
Overall survival at 24 months
Year:
2021
Location:
University of Virginia, USA
Topic:
Metastatic prostate cancer, precision medicine
Document type:
Conference transcript / Grand Rounds presentation
Institution:
University of Virginia Health System; Memorial Sloan Kettering Cancer Center
Speaker / Author:
Karen Autio, MD, MSc
Target audience:
Medical professionals, oncology researchers
Date of presentation:
June 8, 2021
Focus:
Clinical updates, research studies, biomarker-driven therapy
Key terms:
Castration-resistant prostate cancer, androgen deprivation therapy, immune checkpoint inhibitors, PSA, prostate-specific membrane antigen
Year:
2025
Organization:
NICE Technology Appraisal Committee
Document type:
Interests Register
Region:
United Kingdom
Subject:
Conflicts of interest in health technology appraisal
Participants:
Peter Wheatley Price, Warren Linley, David McAllister, Professor Suneil Jain, Rhiannon Owen, Holly Knight
Date of publication:
TBC
Relevant period:
2025
Financial interests:
Pfizer, AstraZeneca, Bayer, Astellas, Johnson & Johnson, Boston Scientific, Teleflex, Accord, Molli Surgical, BXT Nanotherapy
Professional roles:
Committee members, clinical expert, patient expert
Access to trial data:
Yes
Appraisal ID:
4004
Record type:
Committee disclosures
Year:
2020
Organization:
National Institute for Health and Care Excellence (NICE)
Corresponding Group:
British Uro-Oncology Group (BUG)
Document Type:
Final Appraisal Document
Subject:
Abiraterone, Hormone-Sensitive Metastatic Prostate Cancer
Recipient:
STAMPEDE Trial Chief Investigator
Date of Letter:
21 July 2020
Period Covered:
Initial appraisal and appeal process regarding abiraterone
Appeal Grounds:
Unreasonableness of recommendations based on submitted evidence
Key Topics:
Clinical effectiveness, cost-effectiveness, follow-on treatments, quality of life, impact of COVID-19
Document Format:
Letter with appraisal commentary and appeal guidance
Year:
2026
Region / city:
South San Francisco, CA, USA; Munich, Germany
Subject:
Oncology, Cancer Research
Document type:
Research Paper
Organization:
Amgen Research
Author:
Petra Deegen, Oliver Thomas, Olivier Nolan-Stevaux, Shyun Li, Joachim Wahl, Pamela Bogner, Famke Aeffner, Matthias Friedrich, Michael Z. Liao, Katja Matthes, Doris Rau, Benno Rattel, Tobias Raum, Peter Kufer, Angela Coxon, Julie M. Bailis
Target audience:
Researchers, oncologists, biotechnologists
Period of validity:
Not specified
Approval date:
Not provided
Date of changes:
Not provided
Year:
2020
Region / City:
United Kingdom
Topic:
Prostate Cancer, Oncology, Drug Evaluation
Document Type:
Appeal Hearing Transcript
Organization:
National Institute for Health and Care Excellence (NICE)
Author:
Various panel members, including Heather Blake, Professor Nicholas James, and others
Target Audience:
Healthcare professionals, decision-makers, cancer advocacy groups
Effective Period:
September 2020
Approval Date:
3 September 2020
Date of Changes:
None
Year:
2020
Region / Country:
United Kingdom
Subject:
Health technology appraisal, oncology, prostate cancer
Document Type:
Legal/administrative appeal
Organization:
National Institute for Health and Care Excellence (NICE)
Author:
Janssen Pharmaceuticals
Target Audience:
Healthcare regulators, appraisal committees, oncology specialists
Treatment Indication:
Newly diagnosed high-risk metastatic hormone-sensitive prostate cancer in adult men
Therapy Discussed:
Abiraterone in combination with androgen deprivation therapy (ADT)
Procedural History:
Referral in 2016, European Commission approval in 2017, Final Appraisal Determination issued 19 June 2020
Patent Status:
Patent expiration expected September 2022, generic versions available in the USA
Appeal Grounds:
Clinical benefit assessment, quality of life considerations, cost-effectiveness evaluation, procedural fairness
Year:
2023
Study Type:
Clinical trial, Phase 2
Document Type:
Supplementary data
Authors:
Samuel J. Klempner et al.
Intervention:
Zolbetuximab monotherapy, Zolbetuximab + mFOLFOX6, Zolbetuximab + Pembrolizumab
Population:
Patients with advanced or metastatic claudin 18.2–positive gastric or gastroesophageal junction adenocarcinoma
Sample Size:
54
Countries:
France, Italy, Japan, Korea, Taiwan, United States
Cohorts:
1A, 2, 3A
Age Range:
32–79 years
Median Age:
60–65 years
Sex Distribution:
Male 33, Female 21
Ethnicity:
Asian 43%, White 43%, Black 2%, Hispanic/Latino 6%
PK Sampling:
Zolbetuximab, mFOLFOX, Pembrolizumab
HRQOL Assessment:
Multiple cycles per cohort
Follow-up:
30-day safety, 90-day follow-up
Geographic Focus:
Eastern Asia, Central/Eastern Europe, United States, France
End Points:
Pharmacokinetics, health-related quality of life, patient demographics
Data Sources:
Clinical study data, GLOBOCAN 2020, literature references
Supplementary Materials:
Methods, Tables, Figures
Year:
2026
Region / City:
South West London, UK
Topic:
Medical referral for metastatic spinal cord compression
Document Type:
Referral form
Institution:
St George’s Hospital; Royal Marsden Hospital; Royal Surrey County Hospital
Author:
NHS Clinical Team
Target Audience:
Medical professionals, consultants, hospital staff
Date of Implementation:
2026
Referral Hours:
Mon-Thu 08:30-16:30, Fri 08:00-16:00
Contact Emails:
[email protected]; [email protected]; [email protected]
Purpose:
Patient referral and clinical information collection for suspected or confirmed metastatic spinal cord compression
Instructions:
Completion required prior to referral; all imaging studies must be available via SGH PACS
Year:
2026
Region / City:
Not specified
Topic:
Oncology / Pharmacology
Document Type:
Patient Information Leaflet
Institution:
Healthcare Provider / Pharmaceutical Guidance
Drug Name:
Palbociclib
Indications:
HR-positive, HER-2-negative advanced or metastatic breast cancer
Dosage:
125 mg orally once daily for 21 days, followed by 7 days off
Administration:
With food, do not crush or split tablets
Interactions:
Avoid grapefruit; consult before new medications
Side Effects:
Neutropenia, fatigue, nausea, hair loss, mouth sores, liver function changes
Precautions:
Pregnancy and contraception guidelines, handling of body fluids
Storage:
Room temperature below 25°C, keep away from children and pets
Target Audience:
Patients undergoing Palbociclib therapy
Source Type:
Medical guidance / pharmaceutical leaflet
Year:
2023
Institution:
Canberra Health Services
Type:
Clinical Guideline
Target Audience:
Medical officers, registered nurses, supervised students
Scope:
Pediatric patients over 10 kg with respiratory distress requiring NIV
Device:
Hamilton T1 ventilator
Setting:
Emergency Department, Canberra Hospital
Special Considerations:
COVID-19 precautions, consultation with ED consultant, paediatric anaesthetist, and NETS team
Related Units:
ICU, NICU, PICU
Complications Covered:
Respiratory, cardiovascular, skin, gastrointestinal