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Comparative pharmaceutical research study examining the equivalence of a modified single-stage impactor and pharmacopeial cascade impactors for measuring fine particle dose below 5 µm in dry powder and pressurized metered dose inhalers.
Authors: Patrik Andersson; Simon Åslund; Marcus Skogevall; Stina Sjödin; Iain Fraser; Bodil Hakonen; Jan Olof Svensson
Affiliations: Inhalation Product Development, Pharmaceutical Technology & Development, AstraZeneca, Gothenburg, Sweden; Chalmers University, Division of Chemistry and Biochemistry, Gothenburg, Sweden
Organization: AstraZeneca; Chalmers University
City: Gothenburg; Mölndal
Country: Sweden
Type of document: Scientific research article
Subject: Determination of fine particle dose <5 µm in Dry Powder Inhalers and pressurized Metered Dose Inhalers
Equipment studied: Refined-Fast Screening Impactor (R-FSI); Fast Screening Impactor (FSI); Next Generation Impactor (NGI); Andersen Cascade Impactor (ACI)
Products investigated: Multidose Dry Powder Inhaler; Combination product pressurized Metered Dose Inhaler
Methodology: Comparative impactor measurements with interpolation algorithms (Log-Linear and Log-Probit)
Measured parameter: Fine Particle Dose (FPD<5 µm); Fine Particle Fraction (FPF)
Analytical technique: UHPLC with internal standard methodology
Purpose: Evaluation of equivalence between R-FSI and pharmacopeial cascade impactors for QC-release testing
Price: 8 / 10 USD
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Neutronic Analysis of the AP1000 Pressurized Water Reactor
Year: 2023
Region / City: Poznan, Poland
Theme: Neutronic analysis, nuclear engineering, AP1000 reactor
Document type: Research paper
Author: Mikolaj Brzezinski, Jakub Sierchula
Target audience: Researchers, nuclear engineers
Period of validity: 2023
Approval date: 2023
Date of changes: Not specified
Topics: Refined-Fast Impactor Pressurized