№ files_lp_4_process_2_62821
Supplemental clinical research tables presenting eligibility criteria, baseline patient characteristics stratified by bicarbonate levels, congestion scores, and treatment outcome comparisons for acetazolamide versus placebo in hospitalized patients with decompensated heart failure.
Document type: Supplemental appendix tables and figures from a clinical study
Field: Cardiology
Medical condition: Decompensated heart failure
Study design element: Randomized controlled trial supplemental data
Intervention studied: Acetazolamide versus placebo
Population: Adult patients hospitalized with decompensated heart failure
Age criteria: ≥18 years
Inclusion criteria: Hospital admission for decompensated heart failure with signs of volume overload, prior maintenance therapy with oral loop diuretics, elevated NT-proBNP or BNP, documented LVEF
Exclusion criteria: Acute coronary syndrome, congenital heart disease requiring surgery, cardiac transplantation, ventricular assist device, severe hypotension, severe renal impairment, recent acetazolamide therapy, pregnancy or breastfeeding, current SGLT2 inhibitor use
Key biomarkers: NT-proBNP, BNP, bicarbonate (HCO3), sodium, chloride
Clinical measurements: LVEF, blood pressure, heart rate, congestion score, edema score
Comorbidities recorded: Atrial fibrillation, diabetes, hypertension
Baseline comparison groups: <22 mmol/L, 22–27 mmol/L, >27 mmol/L bicarbonate levels
Endpoints referenced: Successful decongestion and treatment effect outcomes
Therapies reported: Loop diuretics, ACE inhibitors, ARB, ARNI, beta-blockers, mineralocorticoid receptor antagonists
Devices reported: Implantable cardioverter-defibrillator (ICD), cardiac resynchronization therapy (CRT)
Price: 8 / 10 USD
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