№ files_lp_4_process_1_34874
Clinical guidance for weight-adjusted Dalteparin administration and monitoring in haemodialysis patients to maintain circuit patency, with specified criteria for dose adjustments, contraindications, side effects, and reversal protocol.
Year: 2026
Institution: Royal Infirmary of Edinburgh
Department: Renal Directorate
Document Type: Clinical guideline
Intended Audience: Healthcare professionals in nephrology and dialysis units
Indication: Prevention of clotting in extracorporeal haemodialysis circuits
Dosage Information: Weight-based Dalteparin administration at start of dialysis
Monitoring: Anti-Xa levels at 1 and 4 hours post-administration under specific conditions
Contraindications: Systemic anticoagulation, invasive procedures within 24 hours, hypersensitivity to heparin or LMWHs, haemophilia, severe thrombocytopenia, recent cerebral haemorrhage, severe liver disease, acute peptic ulceration
Side Effects: Skin rashes, minor bruising, systemic allergic reactions, excessive bleeding, thrombocytopenia, skin necrosis, hyperkalaemia
Reversal: Protamine sulphate if severe bleeding occurs during or within 2 hours post-dialysis
Price: 8 / 10 USD
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