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This document is a clinical protocol for the examination of specimens from patients with Pituitary Neuroendocrine Tumor (PitNET), outlining procedures, tumor types, and histological characteristics.
Version: 1.0.0.0
Protocol Posting Date: March 2025
Note: Procedure
Authors: Ozgur Mete, MD, Sylvia L. Asa, MD, PhD, Shereen Ezzat, MD, Ian E. McCutcheon, MD, CM, FRCS(C), FACS, William McDonald, MD, Arie Perry, MD
Target Audience: Medical professionals in oncology and pathology
Date of Protocol Posting: March 2025
Accreditation Requirement: Not required for accreditation purposes
Type of Document: Medical protocol for tumor examination
Version Contributors: Cancer Committee Authors, Expert Contributors
Date of Creation: March 2025
Summary of Changes: v 1.0.0.0 New protocol
Price: 8 / 10 USD
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SINGLE-CELL TRANSCRIPTOME AND EPIGENETIC PROFILING OF THE PITUITARY GLAND IN NILE TILAPIA
Year: 2024
Region / City: Bodø, Norway; Edinburgh, Scotland; Barcelona, Spain
Subject: Reproductive endocrinology, teleost puberty
Document type: Research article
Institution: Nord University, The Roslin Institute, Institute of Marine Science (ICM)
Authors: L. Colonna, I. Konstantinidis, R.R. Daniels, D. Robledo, J.M.O. Fernandes
Target audience: Researchers in marine biology and fish physiology
Methodology: Single-cell RNA-seq and ATAC-seq profiling
Model organism: Nile tilapia (Oreochromis niloticus)
Experimental conditions: Continuous and ambient light exposure for 4 months
Purpose: Identification of pituitary cell types and markers associated with puberty onset in teleosts
Reference: M. Li, L. Sun, L. Zhou & D. Wang (2024). Gen Comp Endocrinol 345:114395
Rare Collision Tumors: ACTH-Secreting Pituitary Adenoma and Pituicytoma: Histopathological and Ultrastructural Analyses - case report
Year: 2021
Region / City: Córdoba, Argentina
Topic: Collision Tumors, Pituitary Adenomas, Pituicytomas, Endocrinology
Document Type: Case Report
Institution: Universidad Nacional de Córdoba, Clínica Universitaria Reina Fabiola
Author(s): Silvia Carolina Fernández, María Celina Bernhardt, Ezequiel Grondona, Carolina Leimgruber, Virginia Juárez, Ana Clara Venier, María Lorena Bertolino, Emilio Mezzano, Jorge Humberto Mukdsi, Favio Nicolás Pesaola, Ana Lucía De Paul
Target Audience: Medical professionals, endocrinologists, researchers in neuroendocrinology
Period of Validity: N/A
Date of Approval: N/A
Date of Revisions: N/A
Protocol for the Examination of Specimens from Patients with Well-Differentiated Neuroendocrine Tumors (Carcinoid Tumors) of the Colon and Rectum
Version: 5.0.0.0
Protocol Posting Date: December 2023
CAP Laboratory Accreditation Program Protocol Required Use Date: September 2024
Authors: Dhanpat Jain, MD; William V. Chopp, MD; Rondell P. Graham, MBBS
Accreditation Requirements: Core data elements required for clinical care and accreditation purposes. Optional data elements for reporting as determined by local standards.
Procedure: Resection, biopsy, excision biopsy
Tumor Type: Well-differentiated neuroendocrine tumor
Protocol for the Examination of Well-Differentiated Neuroendocrine Tumors of the Jejunum and Ileum, Version 2.0.0.0, December 2023
Year: 2023
Region / City: Not specified
Subject: Pathology, Neuroendocrine Tumors
Document Type: Clinical Protocol
Organization / Institution: College of American Pathologists (CAP)
Authors: Dhanpat Jain, MD; William V. Chopp, MD; Rondell P. Graham, MBBS
Target Audience: Pathologists, Laboratory Personnel
Effective Period: September 2024
Protocol Version: 2.0.0.0
Procedures Covered: Segmental resection, Ileocolic resection
Tumor Types Covered: Well-differentiated neuroendocrine tumors of the jejunum and ileum
Accreditation Required: Yes, for primary resection specimens
Exclusions: Biopsies, recurrent tumors, metastatic tumors, duodenum/ampulla tumors, poorly differentiated NEC, non-GIST sarcomas, lymphomas, GIST
Synoptic Reporting: Core and conditional data elements required
Histologic Grades: G1, G2, G3, GX
Data Elements: Tumor size, focality, mitotic rate, Ki-67 labeling index, pathologic stage, margins
Summary of Changes: AJCC 9 pTNM staging, WHO 5th Edition updates, lymphovascular invasion updated
Protocol for the Examination of Specimens From Patients With Neuroendocrine Tumors (Carcinoid Tumors) of the Duodenum and Ampulla of Vater
Year: 2020
Region / City: Not specified
Topic: Neuroendocrine Tumors, Pathology, Cancer Accreditation
Document Type: Protocol
Organization / Institution: College of American Pathologists (CAP)
Author: Chanjuan Shi, MD, PhD; Volkan Adsay, MD; Emily K. Bergsland, MD; Jordan Berlin, MD; Philip A. Branton, MD; Patrick L. Fitzgibbons, MD; Wendy L. Frankel, MD; Sanjay Kakar, MD; Veronica Klepeis, MD, PhD; David S. Klimstra, MD; Joseph T. Lewis, MD; Laura H. Tang, MD; Mary K Washington, MD, PhD; Eugene Woltering, MD
Target Audience: Pathologists, Oncology Professionals, Medical Institutions
Period of Validity: Effective until November 2020
Approval Date: February 2020
Date of Changes: Not specified
REQUEST FOR PROPOSALS: National Organization for Rare Disorders (NORD) with funding from The NEHI Research Foundation Announces Research Grant Money up to $30,000 US for Neuroendocrine Cell Hyperplasia of Infancy (NEHI)
Year: 2019
Region / City: United States
Topic: Rare diseases, Scientific research, Clinical research, Neuroendocrine cell hyperplasia of infancy (NEHI)
Document Type: Research grant proposal
Organization: National Organization for Rare Disorders (NORD)
Author: NORD
Target Audience: Researchers, Clinical investigators, Healthcare professionals
Period of Validity: From June 18, 2019
Approval Date: N/A
Date of Amendments: N/A
Protocol for the Examination of Specimens From Patients with Well-Differentiated Neuroendocrine Tumors (Carcinoid Tumors) of the Duodenum and Ampulla of Vater
Year: 2023
Region / City: Global
Subject: Pathology, Oncology
Document Type: Protocol
Organization / Institution: CAP
Authors: Dhanpat Jain, MD; William V. Chopp, MD; Rondell P. Graham, MBBS
Target Audience: Pathologists, Oncology professionals
Effective Period: September 2024
Approval Date: December 2023
Revision Date: December 2023
Protocol for the Examination of Specimens From Patients with Well-Differentiated Neuroendocrine Tumors (Carcinoid Tumors) of the Duodenum and Ampulla of Vater
Version: 2.0.0.1
Protocol Posting Date: June 2024
CAP Laboratory Accreditation Program Protocol Required Use Date: September 2024
Year: 2024
Region / city: Duodenum and Ampulla of Vater
Topic: Neuroendocrine tumors
Document type: Medical Protocol
Organization / institution: CAP (College of American Pathologists)
Authors: Dhanpat Jain, MD; William V. Chopp, MD; Rondell P. Graham, MBBS
Target audience: Pathologists, Oncology Specialists, Medical Institutions
Effective period: From June 2024
Approval date: June 2024
Date of amendments: Version 2.0.0.1 (June 2024)
Topics: PitNET Pituitary Neuroendocrine