№ files_lp_4_process_3_129918
Supplementary methodological documentation of a multi-dataset neuroimaging study within the ENIGMA Consortium describing participant assessment, MRI processing, quality control procedures, and mathematical definitions used for cortical thickness–based structural covariance network analysis in autism spectrum disorder.
Year: 1994–2013
Field: Neuroscience
Topic: Brain structural covariance networks in autism spectrum disorder
Document type: Supplementary methodological documentation
Organization: ENIGMA Consortium
Research group: ENIGMA ASD Working Group
Source study title: Subtly altered topological asymmetry of brain structural covariance networks in autism spectrum disorder across 43 datasets from the ENIGMA consortium
Diagnostic framework: DSM-IV and DSM-IV-TR
Assessment instruments: Autism Diagnostic Observation Schedule-Generic (ADOS)
Data type: MRI structural imaging and cortical thickness measurements
Software used: FreeSurfer (recon-all pipeline)
Quality control protocol: ENIGMA imaging protocols
Participants with ASD: Individuals across the autism spectrum with available MRI and clinical data
Control participants: Typically developing individuals without ASD diagnosis
Network analysis methods: Intra-individual structural covariance, clustering coefficient, shortest path length, small-worldness index
Datasets included: 43 datasets
Supplementary materials: Supplementary methods (pages 2–6) and 20 supplementary tables in a separate spreadsheet file
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