№ files_lp_4_process_2_57730
Supplementary information for a clinical study on the effects of MARS therapy compared to standard medical treatment in patients with acute-on-chronic liver failure, including patient characteristics, organ failure assessment, and survival outcomes.
Year: 2026
Study type: Clinical research
Patient population: Adults with acute-on-chronic liver failure
Treatment evaluated: MARS therapy versus standard medical therapy (SMT)
Institutions: Multiple European hepatology centers
Authors: Hans U. Gerth, Michele Pohlen, Gerold Thölking, Hermann Pavenstädt, Marcus Brand, Anna Hüsing-Kabar, Christian Wilms, Miriam Maschmeier, Iyad Kabar, Marco Pavesi, Vicente Arroyo, Rafael Banares, Hartmut H. J. Schmidt
Sample size: 257 patients (Muenster cohort: 101; RELIEF cohort: 156)
Primary endpoints: 14-day and 28-day mortality
Secondary endpoints: Organ failure progression, transplant-free survival
Methods: CLIF-C organ failure scoring, hemodialysis, laboratory monitoring, infection screening, supportive care for cirrhosis complications
Follow-up period: Up to 28 days post-treatment
Data analysis: Survival analysis, recursive partitioning, subgroup comparisons
Document type: Supplementary material for a peer-reviewed journal article
Clinical context: Acute-on-chronic liver failure management and outcomes
Price: 8 / 10 USD
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