№ files_lp_3_process_9_17491
Supplementary clinical trial table defining hematologic and non-hematologic dose-limiting toxicity criteria, grading thresholds, treatment delay parameters, and administration requirements within 6-week treatment cycles.
Document type: Supplementary table
Subject: Prespecified dose-limiting toxicities
Field: Oncology clinical research
Interventions mentioned: Ipilimumab; Pegylated interferon alfa-2b; Pembrolizumab
Treatment cycle duration: 6 weeks
Toxicity categories: Hematologic; Non-hematologic
Evaluation criteria: CTCAE grade-based definitions (Grade 3–5)
Dose-limiting criteria: Toxicity severity; Febrile neutropenia; Thrombocytopenia; Treatment delays; Incomplete treatment administration
Administration delay threshold: >14 days
Completion threshold during evaluation period: ≥80% of planned treatment
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