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Academic research project description outlining a multi-omic investigation of meningeal immune architecture, cellular interactions and molecular mechanisms associated with cortical pathology and neurodegeneration in progressive multiple sclerosis.
Year: Not specified
Field of study: Neuroscience; Neuroimmunology; Molecular Biology
Topic: Meningeal inflammation and immune cell interactions in multiple sclerosis
Document type: PhD research project description
Institution: Imperial College London
Faculty: Faculty of Medicine
Author / Supervisor: Roberta Magliozzi
Research focus: Multi-omic analysis of meningeal immune landscape and tertiary lymphoid-like structures in progressive multiple sclerosis
Methods: Spatial transcriptomics; Mass spectrometry; Genome-wide association data integration; In-vitro cell culture models using hiPSC-derived neuronal and glial cells
Biological material: Post-mortem meninges from multiple sclerosis donors and neurologically healthy controls
Sample size: 20 multiple sclerosis cases and 10 control individuals
Research objectives: Identification of immune signatures, cellular interactions and molecular pathways associated with neuro-axonal damage and disease progression
Experimental models: Human-induced pluripotent stem cell-derived neuronal and glial cell lines
Funding: UKRI stipend and Faculty of Medicine course fees for three years with additional research consumables funding
Target applicants: Graduates with honours degree in Biomedical Sciences and background in neuroscience, computer science, molecular biology or cell culture
Application materials: Curriculum vitae and cover letter with contact details of two referees
Contact person: Roberta Magliozzi
Price: 8 / 10 USD
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Characterizing the role of senescence in neurodegenerative diseases, cancer and ageing
Year: 2026
Institution: University of Leicester
College/School: College of Life Sciences, MCB
First Supervisor: Professor Salvador Macip
Second Supervisor: Professor Shaun Cowley
Email First Supervisor: [email protected]
Email Second Supervisor: [email protected]
Project Type: MIBTP studentship
Research Focus: Ageing, senescence, neurodegenerative diseases, cancer
Collaborators: BarcelonaBeta Brain Research Center, Division of Chemistry at University of Leicester
Techniques: Protein/DNA/RNA extraction, microscopy, immunofluorescence, immunohistochemistry, subcellular fractionation, gradient separation, cloning, transfection, RNA interference, flow cytometry, Western blots, luciferase assays, qRT-PCR, microarrays, mass spectrometry, image processing, statistical analysis
Program of the Neurodegenerative Disease and Sigma-1 Receptor Conference, October 26–27
Year: 2022
Location: Europe (France, Belgium, Italy, Sweden, Estonia, Israel, Slovakia, Latvia, Czech Republic)
Theme: Neurodegenerative diseases, Wolfram syndrome, ALS, Parkinson’s disease, ATAD3A disorders, Sigma-1 receptor
Document type: Conference program
Organizers: Various academic and clinical institutions in Europe
Sessions: 7 scientific sessions, poster presentations, gala dinner, sightseeing
Presenters: Nolwen Le Floch, Benjamin Delprat, Elodie Richard, Catherine Verfaillie, Marco Peviani, Angela Cenci Nilsson, Vinay Choubey, Tamar Harel, Shlomit Ezer, Martina Skopkova, Tangui Maurice, Patricia Melnyk, Liga Zvejniece, Geert Bultynck, Michal Cagalinec, Jan Skoda, Barbara Ehrlich, Matej Hotka, Alexandra Zahradnikova Jr
Dates: October 26–27, Wednesday–Thursday
Target audience: Researchers, clinicians, and professionals in neurodegenerative disease research
Format: In-person and online presentations
REVISEDTau Tubulin Kinase 1 (TTBK1), a new player in the fight against neurodegenerative diseases
Year: 2023
Region / city: Madrid, Spain
Field: Neurodegenerative diseases
Document type: Review
Author: Vanesa Nozal, Ana Martinez
Target audience: Researchers, clinicians, biologists
Period of application: Not specified
Approval date: Not specified
Date of changes: Not specified
Familial Disease Cohorts Work Package 5: Biomarker Validation in Inherited Neurodegenerative Diseases
Year: 2020
Region / Institution: University College London
Programme: DPUK Work Package 5
Related Work Packages: WP3 (UK Biobank), WP4 (1946 birth cohort), WP6
Thematic Area: Neurodegenerative diseases and biomarkers
Diseases Covered: Familial Alzheimer’s disease, Familial frontotemporal dementia, Huntington’s disease, Familial Parkinson’s disease (LRRK2)
Cohorts: UCL FAD, DIAN, GENFI, Track HD, LRRK2 cohort
Type of Document: Research programme summary and output report
Organ / Institution: University College London
Collaborating Initiatives: DIAN, GENFI, Track HD, UK Biobank
Main Biomarkers Studied: Serum neurofilament light (NfL), plasma phospho-tau181, cortical mean diffusivity, PET imaging markers
Study Population: Individuals with autosomal dominant inherited neurodegenerative diseases and non-mutation carrier siblings
Research Focus: Presymptomatic to symptomatic disease progression and biomarker validation
Outputs: Peer-reviewed publications and longitudinal cohort analyses
Topics: meningeal multi-omic neurodegenerative